Bioinspired Andrias davidianus-Derived wound dressings for localized drug-elution

Summary Background: To evaluate the implementation of the guidelines of the German Society of Phlebology for venous crural ulcer a survey was conducted during the annual meeting of the German Society of Phlebology 2008 in Bochum. Methods: All 719 medical participants got an anonymized questionnaire asking for supply of crural ulcer in their institution. Results: The recurrent 66 questionnaires (9.2%) were filled by colleagues from practice or hospital, mostly surgeons, dermatologists, phlebologists and vascular surgeons. As basic diagnostics vein doppler (56.1%), duplex (75.8%) or measurement of brachial-ankleindex (83.3%) were performed. Compression therapy is used in all institutions. Mainly used wound dressings are polyurethane foam dressings, alginates, hydrocolloids and silver dressings. About 2/3 conduct surgical therapy of ulcers. Conclusion: Supply of ulcus cruris by the participants of the annual meeting of the DGP corresponds mainly, but not in all aspects to the guidelines. Further efforts for a spread of the guidelines are necessary.

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Novel tissue engineering scaffolds as wound dressings loaded with Alkannins/Shikonins as active ingredients

10.1055/s-0039-3400068 ◽

2019 ◽

Author(s):

AS Arampatzis ◽

K Theodoridis ◽

E Aggelidou ◽

KN Kontogiannopoulos ◽

I Tsivintzelis ◽

...

Keyword(s):

Tissue Engineering ◽

Wound Dressings ◽

Active Ingredients ◽

Tissue Engineering Scaffolds

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Isaac Bayley Balfour, Sphagnum moss, and the Great War (1914–1918)

Archives of Natural History ◽

10.3366/anh.2015.0274 ◽

2015 ◽

Vol 42 (1) ◽

pp. 1-9 ◽

Cited By ~ 2

Author(s):

P. G. Ayres

Keyword(s):

United States ◽

Academic Career ◽

The United States ◽

Royal Botanic Garden ◽

Wound Dressings ◽

Sphagnum Moss ◽

Botanic Garden ◽

Working Model ◽

Sphagnum Bog ◽

The Great War

Isaac Bayley Balfour was a systematist specializing in Sino-Himalayan plants. He enjoyed a long and exceptionally distinguished academic career yet he was knighted, in 1920, “for services in connection with the war”. Together with an Edinburgh surgeon, Charles Cathcart, he had discovered in 1914 something well known to German doctors; dried Sphagnum (bog moss) makes highly absorptive, antiseptic wound dressings. Balfour directed the expertise and resources of the Royal Botanic Garden, Edinburgh (of which he was Keeper), towards the identification of the most useful Sphagnum species in Britain and the production of leaflets telling collectors where to find the moss in Scotland. By 1918 over one million such dressings were used by British hospitals each month. Cathcart's Edinburgh organisation, which received moss before making it into dressings, proved a working model soon adopted in Ireland, and later in both Canada and the United States.

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The Role of Stent Design and Polymers in Safety Outcomes – A Review

European Cardiology Review ◽

10.15420/ecr.2012.8.1.63 ◽

2012 ◽

Vol 8 (1) ◽

pp. 63

Author(s):

Carlo Zivelonghi ◽

Giulia Geremia ◽

Michele Pighi ◽

Flavio Ribichini ◽

◽

...

Keyword(s):

Clinical Performance ◽

Drug Carrier ◽

Chemical Properties ◽

Vascular Wall ◽

Radial Force ◽

Vascular Trauma ◽

Polymer Composition ◽

Drug Eluting Stent ◽

Stent Design ◽

Drug Elution

Each component of a drug-eluting stent (DES) contributes to the safety of the device. Continuous efforts are being dedicated to the search of the optimal compromise between facility of use, safety and long-term efficacy. Shorter balloons reduce the vascular trauma beyond the stent struts; the metallic composition of the stent platform and the platform itself interact with the vascular wall in a long-lasting equilibrium between radial force, vessel patency and reparative cellular regrowth. The modality of drug elution is largely regulated by the chosen drug carrier, rather than by the chemical properties of the drug itself. Drug elution can be accomplished by permanent polymers that remain in the vessel wall forever, by biodegradable polymers that leave the naked metallic structure behind after their complete absorption, or even by direct release of the drug from stent reservoirs. The clinical performance of DESs has been exhaustively assessed in a large number of studies that have showed rapid and continuous improvements, from the first-generation DESs to the latest devices, based on substantial changes in stent design and polymer composition.

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