Enhanced photothermal therapy of biomimetic polypyrrole nanoparticles through improving blood flow perfusion

Biomaterials ◽  
2017 ◽  
Vol 143 ◽  
pp. 130-141 ◽  
Author(s):  
Xuejun Wang ◽  
Haichun Li ◽  
Xianping Liu ◽  
Ye Tian ◽  
Huishu Guo ◽  
...  
Keyword(s):  
Blood Flow ◽  
Photothermal Therapy ◽  
Flow Perfusion ◽  
Polypyrrole Nanoparticles

Abstract 3598: Critical Role of Th17-CD4 + T cells in Angiogenic Response to Hindlimb Ischemia in Mice

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Takeki Hata ◽  
Masafumi Takahashi ◽  
Masanori Kawaguchi ◽  
Yuichiro Kashima ◽  
Yuji Shiba ◽  
...  
Keyword(s):  
T Cells ◽  
Blood Flow ◽  
Th17 Cells ◽  
Critical Role ◽  
Interleukin 17 ◽  
Hindlimb Ischemia ◽  
Capillary Formation ◽  
Angiogenic Response ◽  
Flow Perfusion

Background: Accumulating evidence indicates that CD4 + T cells contribute to the development of collateral vesssels in ischemic tissue; however, little is known about the responsible subset of CD4 + T cells in the induction of angiogenesis. Th17 cells are recently identified as a new subset of CD4 + T cells and have been associated with the pathogenesis of certain autoimmune diseases. Th17 cells specifically secrete interleukin-17 (IL-17) and regulate various biological functions. The purpose of this study is to investigate the role of CD4 + T and Th17 cells in angiogenic response to hindlimb ischemia. Methods and Results: Unilateral hindlimb ischemia was produced in wild-type (WT: C57BL/6, 8- to 10-week-old) mice treated with or without a neutralizing antibody against CD4. Blood flow perfusion and capillary formation were assessed by using a laser Doppler perfusion imaging (LDPI) and CD31 immunostaining, respectively. Well-developed collateral vessels and capillary formation were observed in WT mice in response to hindlimb ischemia. Treatment with a neutralizing anti-CD4 antibody resulted in almost complete CD4 + T cell depletion (flow cytometry analysis, control: 45.4% vs. antibody: 1.0%) and a significant decrease in angiogenesis after the induction of hindlimb ischemia (LDPI, 21 days, control: 0.61 ± 0.1 vs. antibody: 0.41 ± 0.1, p<0.05). IL-17-deficient (IL-17 −/− ) mice also showed a significant reduction of blood flow perfusion, compared with WT mice (LDPI, day 14: 0.56 ± 0.3 vs. 0.31 ± 0.2, p<0.05; day 21: 0.66 ± 0.3 vs. 0.37 ± 0.3, p=0.05). IL-17 −/− mice had severe ischemic damage of the limb and resulted in a 25% incidence of autoamputation by day 21 (no limb loss in WT mice). Furthermore, capillary formation was also decreased significantly in IL-17 −/− mice (692.9 ± 165.6/mm 2 vs. 1223.3 ± 267.3/mm 2 , p<0.01). Conclusion : These findings demonstrate that Th17 cells, a new subset of CD4 + T cells, contribute to the angiogenic response to hindlimb ischemia and provide new insights into the mechanism by which T cells promote collateral development and angiogenesis.

Polypyrrole Based Nanotheranostic Agent for MRI Guided Photothermal-Chemodynamic Synergistic Cancer Therapy

Nanoscale ◽  
2021 ◽  
Author(s):  
Bangyi Zhou ◽  
Chenhui Yin ◽  
Qiang Feng ◽  
Yiting Wu ◽  
Xiaoyu Pan ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Photothermal Therapy ◽  
Polypyrrole Nanoparticles ◽  
Good Biocompatibility ◽  
Mri Guided

Polypyrrole nanoparticles (PPy) have been widely studied in tumor photothermal therapy (PTT) for their significant photostability, good biocompatibility, and excellent photothermal performance. Herein, we reported bovine serum albumin (BSA) stabilized...

Enhanced anticancer effect of ROS-boosted photothermal therapy by using fucoidan-coated polypyrrole nanoparticles

2021 ◽  
Vol 166 ◽  
pp. 98-107 ◽  
Author(s):  
Kun-Ying Lu ◽  
Pei-Ru Jheng ◽  
Long-Sheng Lu ◽  
Lekshmi Rethi ◽  
Fwu-Long Mi ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Anticancer Effect ◽  
Polypyrrole Nanoparticles

Near-Infrared Spectroscopy to Monitor Peripheral Blood Flow Perfusion

2007 ◽  
Vol 22 (1) ◽  
pp. 37-43 ◽  
Author(s):  
François Harel ◽  
André Denault ◽  
Quam Ngo ◽  
Jocelyn Dupuis ◽  
Paul Khairy
Keyword(s):  
Blood Flow ◽  
Infrared Spectroscopy ◽  
Near Infrared Spectroscopy ◽  
Peripheral Blood ◽  
Near Infrared ◽  
Peripheral Blood Flow ◽  
Flow Perfusion

Effects of histamine, acetylcholine, and norepinephrine on gastric vascular resistance

1963 ◽  
Vol 204 (6) ◽  
pp. 1013-1017 ◽  
Author(s):  
Eugene D. Jacobson
Keyword(s):  
Blood Flow ◽  
Gastric Secretion ◽  
Vascular Resistance ◽  
Constant Flow ◽  
Vascular Bed ◽  
Naturally Occurring ◽  
Flow Perfusion ◽  
Wide Range ◽  
Drug Doses

The vasoactive properties of three naturally occurring substances which influence gastric secretion were investigated in the gastric vascular bed. A constant flow perfusion of the canine stomach was employed and vascular pressures were recorded in response to a wide range of drug doses. Histamine was found to decrease vascular resistance appreciably in the concentration range 0.01–0.50 µg/ml blood perfusing the stomach. Gastric vascular resistance declined in response to acetylcholine infusion when the concentration exceeded 0.10 µg/ml blood. Norepinephrine increased resistance to blood flow appreciably when perfusion concentration was greater than 0.05 µg/ml blood. It was also found that the responses to histamine and norepinephrine were esssentially the same whether the agents were infused locally or systemically for calculated concentrations in the gastric perfusate. These findings substantiate the concept that gastric secretory stimulants dilate, and that gastric secretory inhibitors constrict the gastric vascular bed.

scholarly journals B-16 * The Effect of Inattention on Cerebral Blood Flow Perfusion

2014 ◽  
Vol 29 (6) ◽  
pp. 542-542
Author(s):  
M. Zusman ◽  
D. Amen ◽  
K. Willeumier ◽  
D. Taylor ◽  
C. Golden
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Flow Perfusion
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