New phenylpropanoid-conjugated pentacyclic triterpenoids from the whole plants of Leptopus lolonum with their antiproliferative activities on cancer cells

2021 ◽  
pp. 104628
Author(s):  
Shi-Zhou Qi ◽  
Ting Liu ◽  
Miao Wang ◽  
Xin-Xin Zhang ◽  
Yi-Ren Yang ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Pentacyclic Triterpenoids ◽  
Whole Plants ◽  
Antiproliferative Activities

Antioxidant, antiangiogenic and antiproliferative activities of root methanol extract of Calliandra portoricensis in human prostate cancer cells

2015 ◽  
Vol 13 (3) ◽  
pp. 185-193 ◽  
Author(s):  
Oluwatosin Adaramoye ◽  
Bettina Erguen ◽  
Olubukola Oyebode ◽  
Bianca Nitzsche ◽  
Michael Höpfner ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Methanol Extract ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells ◽  
Antiproliferative Activities

scholarly journals Triterpenoids and Alkaloids from the Roots of Peganum Nigellastrum

2008 ◽  
Vol 3 (2) ◽  
pp. 1934578X0800300
Author(s):  
Zhongze Ma ◽  
Yoshio Hano ◽  
Feng Qiu ◽  
Gang Shao ◽  
Yingjie Chen ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Methyl Ester ◽  
Cancer Cells ◽  
Acid Methyl Ester ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells ◽  
Pentacyclic Triterpenoids ◽  
Acid Methyl ◽  
Androgen Independent ◽  
Chemical Evidence

Four lupane-type triterpenoids (1–4) and seven alkaloids (5–11) were isolated from the roots of Peganum nigellastrum. On the basis of spectroscopic and chemical evidence, the structures of the compounds were elucidated as 3α-hydroxy-27- trans-caffeoyloxylup-20(29)-en-28-oic acid methyl ester (1), 3β-hydroxy-27- trans-caffeoyloxylup-20(29)-en-28-oic acid methyl ester (2), 3α-acetoxy-27- trans-caffeoyloxylup-20(29)-en-28-oic acid methyl ester (3), 3β-acetoxy-27- trans-caffeoyloxylup-20(29)-en-28-oic acid methyl ester (4), luotonin C (5), luotonin D (6), harmine (7), harmol (8), harmaline (9), deoxyvasicinone (10) and vasicinone (11). Compounds 1, 3 and 4 are novel triterpenoids, and these pentacyclic triterpenoids were evaluated for their cytotoxicity against the androgen-sensitive LNCaP and androgen-independent PC-3 human prostate cancer cells.

Novel triterpenoids isolated from raisins exert potent antiproliferative activities by targeting mitochondrial and Ras/Raf/ERK signaling in human breast cancer cells

2016 ◽  
Vol 7 (7) ◽  
pp. 3244-3251 ◽  
Author(s):  
Juan Liu ◽  
Yihai Wang ◽  
Rui Hai Liu ◽  
Xiangjiu He
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Erk Signaling ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
The World ◽  
Antiproliferative Activities

Raisins are produced in many regions of the world and may be eaten raw or used in cooking, baking and brewing.

scholarly journals New Antiproliferative Dibenzo-α-Pyrone From Whole Plants of Centella asiatica

2021 ◽  
Vol 16 (3) ◽  
pp. 1934578X2110030
Author(s):  
Yi Liu ◽  
Wei Wang ◽  
Jian Miao
Keyword(s):  
Cancer Cells ◽  
Chemical Structure ◽  
Inhibitory Concentration ◽  
Human Cancer ◽  
Centella Asiatica ◽  
Mass Spectrometric ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines ◽  
Whole Plants ◽  
Mcf 7

A new compound, 1,3,7,9-tetrahydroxy-6 H-dibenzo[ b, d]pyran-6-one (1), together with 6 known compounds (2-7), was isolated from the extract of whole plants of Centella asiatica. The chemical structure was elucidated on the basis of spectroscopic and mass spectrometric analyses. All the isolates were evaluated for their cytotoxicities against 4 human cancer cell lines (MCF-7, HepG2, Hela, and A549). Among them, compound 1 was found to exhibit significant cytotoxicity on MCF-7 and HepG2 cancer cells with half-maximal inhibitory concentration values of 4.1 and 7.2 µM, respectively.

scholarly journals Hydrazine-Containing Heterocycle Cytochalasan Derivatives From Hydrazinolysis of Extracts of a Desert Soil-Derived Fungus Chaetomium madrasense 375

2021 ◽  
Vol 9 ◽  
Author(s):  
Qingfeng Guo ◽  
Jinhua Chen ◽  
Yuwei Ren ◽  
Zhenhua Yin ◽  
Juanjuan Zhang ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Cancer Cells ◽  
Human Cancer ◽  
Drug Resistant ◽  
Hydrazine Monohydrate ◽  
Chemical Libraries ◽  
Human Cancer Cells ◽  
First Time ◽  
Antiproliferative Activities ◽  
Positive Controls

“Diversity-enhanced extracts” is an effective method of producing chemical libraries for the purpose of drug discovery. Three rare new cytochalasan derivative chaetoglobosins B1-B3 (1–3) were obtained from chemically engineered crude broth extracts of Chaetomium madrasense 375 prepared by reacting with hydrazine monohydrate and four known metabolite chaetoglobosins (4–7) were also identified from the fungus. The structures were identified by NMR and MS analysis and electronic circular dichroism simulation. In addition, the antiproliferative activities of these compounds were also evaluated, and the drug-resistant activities of cytochalasans were evaluated for the first time. Compound 6 possessed potent activity against four human cancer cells (A549, HCC827, SW620, and MDA-MB-231), and two drug-resistant HCC827 cells (Gefitinib-resistant, Osimertinib-resistant) compared with the positive controls.

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