Maternal Stress Predicts Dentate Gyrus Microstructure, Dentate Gyrus-Orbitofrontal Functional Connectivity, Decreased Cognitive Flexibility, Increased Rumination and Depressive Symptoms in Adult Offspring

2021 ◽  
Vol 89 (9) ◽  
pp. S66
Author(s):  
Milenna van Dijk ◽  
Yun Wang ◽  
David Semanek ◽  
Eyal Abraham ◽  
Marc J. Gameroff ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Functional Connectivity ◽  
Dentate Gyrus ◽  
Cognitive Flexibility ◽  
Maternal Stress ◽  
Adult Offspring

scholarly journals Maternal stress and depressive symptoms and adolescents’ body mass index: a prospective study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Maaike Koning ◽  
Jacqueline Vink ◽  
Tommy L. S. Visscher ◽  
Junilla Larsen
Keyword(s):  
Mental Health ◽  
Depressive Symptoms ◽  
Prospective Study ◽  
Perceived Stress ◽  
Maternal Stress ◽  
Maternal Mental Health ◽  
Cross Sectional ◽  
Domain Specific ◽  
General Stress ◽  
Adolescent Offspring

Abstract Background Growing evidence suggests that maternal mental health issues are associated with (young) children’s weight outcomes. However, most studies have been limited by cross-sectional designs and have been aimed at (younger) children. The current prospective study focuses on the link between maternal mental health (i.e., psychological stress and depressive symptoms) and adolescents’ zBMI development. Methods The participants in the present study were part of wave 1 and 2 of a longitudinal study on Dutch adolescents’ and their parents’ health behavior. Adolescents (aged 10–14) and their parents were recruited through six secondary schools in the South and the East of the Netherlands. For this study, we only included biological mothers and their adolescent children who participated in both waves, with data on the main measures in both waves, leaving a final sample of 336 biological mother-child dyads. Adolescents height and weight were measured, and both parents and adolescents filled in validated questionnaires on perceived stress and depressive symptoms and answered additional questions concerning domain-specific stress. Regression analyses were performed in R to examine longitudinal links between maternal stress and depressive symptoms at baseline (T1) and adolescents’ BMI standard deviation scores (zBMI) 6 months later (T2), corrected for baseline zBMI and covariates. Results Maternal general perceived stress (β = .20, p = .002) at T1 preceded higher adolescents’ zBMI at T2, after controlling for baseline zBMI and other covariates, whereas maternal depressive symptoms at T1 (β = −.05, p = .44) and other domain-specific stress did not (maternal financial stress, maternal stress at work, maternal stress at home). Additionally, lower educational level among adolescents (β = .16, p = .001) and adolescent depressive symptoms (β = .16, p = .001) was associated with a higher zBMI at T2. Conclusions Results suggest that maternal general stress, but not depressive symptoms, may influence adolescents’ weight development. Our findings warrant future investigation on whether and how general stress among mothers may predict weight increases of their adolescent offspring.

Longitudinal study of perinatal maternal stress, depressive symptoms and anxiety

Midwifery ◽  
2014 ◽  
Vol 30 (6) ◽  
pp. 795-801 ◽  
Author(s):  
Shwu-Ru Liou ◽  
Panchalli Wang ◽  
Ching-Yu Cheng
Keyword(s):  
Depressive Symptoms ◽  
Longitudinal Study ◽  
Maternal Stress

Increased interhemispheric functional connectivity in college students with non-clinical depressive symptoms in resting state

2015 ◽  
Vol 589 ◽  
pp. 67-72 ◽  
Author(s):  
Xin-Hua Wei ◽  
Ji-Liang Ren ◽  
Wen-Hua Liu ◽  
Rui-Meng Yang ◽  
Xiang-Dong Xu ◽  
...  
Keyword(s):  
College Students ◽  
Depressive Symptoms ◽  
Functional Connectivity ◽  
Resting State

Epigenetic upregulation of acid-sensing ion channel 1 contributes to gastric hypersensitivity in adult offspring rats with prenatal maternal stress

Pain ◽  
2020 ◽  
Vol 161 (5) ◽  
pp. 989-1004 ◽  
Author(s):  
Hong-Jun Wang ◽  
Xue Xu ◽  
Ping-An Zhang ◽  
Meng Li ◽  
You-Lang Zhou ◽  
...  
Keyword(s):  
Ion Channel ◽  
Maternal Stress ◽  
Adult Offspring ◽  
Prenatal Maternal Stress

Measuring Cognitive Flexibility with the Flexible Item Selection Task: From fMRI Adaptation to Individual Connectome Mapping

2020 ◽  
Vol 32 (6) ◽  
pp. 1026-1045 ◽  
Author(s):  
Dina R. Dajani ◽  
Paola Odriozola ◽  
Melanie Winters ◽  
Willa Voorhies ◽  
Selene Marcano ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Cognitive Flexibility ◽  
Brain Regions ◽  
Individual Variability ◽  
Selection Task ◽  
Anterior Cingulate ◽  
Item Selection ◽  
Neural Activation ◽  
Subcortical Regions ◽  
Inferior Frontal Junction

Cognitive flexibility, the ability to appropriately adjust behavior in a changing environment, has been challenging to operationalize and validate in cognitive neuroscience studies. Here, we investigate neural activation and directed functional connectivity underlying cognitive flexibility using an fMRI-adapted version of the Flexible Item Selection Task (FIST) in adults ( n = 32, ages 19–46 years). The fMRI-adapted FIST was reliable, showed comparable performance to the computer-based version of the task, and produced robust activation in frontoparietal, anterior cingulate, insular, and subcortical regions. During flexibility trials, participants directly engaged the left inferior frontal junction, which influenced activity in other cortical and subcortical regions. The strength of intrinsic functional connectivity between select brain regions was related to individual differences in performance on the FIST, but there was also significant individual variability in functional network topography supporting cognitive flexibility. Taken together, these results suggest that the FIST is a valid measure of cognitive flexibility, which relies on computations within a broad corticosubcortical network driven by inferior frontal junction engagement.

scholarly journals Obesity status and obesity-associated gut dysbiosis effects on hypothalamic structural covariance

2021 ◽  
Author(s):  
O. Contreras-Rodriguez ◽  
M. Arnoriaga-Rodríguez ◽  
R. Miranda-Olivos ◽  
G. Blasco ◽  
C. Biarnés ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Functional Connectivity ◽  
Orbitofrontal Cortex ◽  
Executive Dysfunction ◽  
Structural Covariance ◽  
Gut Dysbiosis ◽  
Obesity Status ◽  
Subcortical Nuclei ◽  
Parietal Cortices

Abstract Background Functional connectivity alterations in the lateral and medial hypothalamic networks have been associated with the development and maintenance of obesity, but the possible impact on the structural properties of these networks remains largely unexplored. Also, obesity-related gut dysbiosis may delineate specific hypothalamic alterations within obese conditions. We aim to assess the effects of obesity, and obesity and gut-dysbiosis on the structural covariance differences in hypothalamic networks, executive functioning, and depressive symptoms. Methods Medial (MH) and lateral (LH) hypothalamic structural covariance alterations were identified in 57 subjects with obesity compared to 47 subjects without obesity. Gut dysbiosis in the subjects with obesity was defined by the presence of high (n = 28) and low (n = 29) values in a BMI-associated microbial signature, and posthoc comparisons between these groups were used as a proxy to explore the role of obesity-related gut dysbiosis on the hypothalamic measurements, executive function, and depressive symptoms. Results Structural covariance alterations between the MH and the striatum, lateral prefrontal, cingulate, insula, and temporal cortices are congruent with previously functional connectivity disruptions in obesity conditions. MH structural covariance decreases encompassed postcentral parietal cortices in the subjects with obesity and gut-dysbiosis, but increases with subcortical nuclei involved in the coding food-related hedonic information in the subjects with obesity without gut-dysbiosis. Alterations for the structural covariance of the LH in the subjects with obesity and gut-dysbiosis encompassed increases with frontolimbic networks, but decreases with the lateral orbitofrontal cortex in the subjects with obesity without gut-dysbiosis. Subjects with obesity and gut dysbiosis showed higher executive dysfunction and depressive symptoms. Conclusions Obesity-related gut dysbiosis is linked to specific structural covariance alterations in hypothalamic networks relevant to the integration of somatic-visceral information, and emotion regulation.

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