Genetic Overlap Profiles of Cognitive Ability in Psychotic and Affective Illnesses: A Multi-Site Study of Multiplex Pedigrees

We investigate the link between genes, psychological traits, and political engagement using a new data set containing information on a large sample of young German twins. The TwinLife Study enables us to examine the predominant model of personality, the Big Five framework, as well as traits that fall outside the Big Five, such as cognitive ability, providing a more comprehensive understanding of the underpinnings of political engagement. Our results support previous work showing genetic overlap between some psychological traits and political engagement. More specifically, we find that cognitive ability and openness to experience are correlated with political engagement and that common genes can explain most of the relationship between these psychological traits and political engagement. Relationships between genes, psychological traits, and political engagement exist even at a fairly young age, which is an important finding given that previous work has relied heavily on older samples to study the link between genes, psychological traits, and political engagement.

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Rare disruptive variants in the DISC1 Interactome and Regulome: association with cognitive ability and schizophrenia

10.1101/083816 ◽

2016 ◽

Author(s):

Shaolei Teng ◽

Pippa A. Thomson ◽

Shane E. McCarthy ◽

Melissa Kramer ◽

Stephanie Muller ◽

...

Keyword(s):

Cognitive Ability ◽

Rare Variants ◽

Psychiatric Patients ◽

Large Set ◽

Altered Expression ◽

Psychiatric Illnesses ◽

Genetic Overlap ◽

Show Evidence ◽

Complete Sequencing ◽

Recurrent Major Depressive Disorder

ABSTRACTSchizophrenia (SCZ), bipolar disorder (BD) and recurrent major depressive disorder (rMDD) are common psychiatric illnesses. All have been associated with lower cognitive ability, and show evidence of genetic overlap and substantial evidence of pleiotropy with cognitive function and neuroticism. Disrupted in schizophrenia 1 (DISC1) protein directly interacts with a large set of proteins (DISC1 Interactome) that are involved in brain development and signaling. Modulation of DISC1 expression alters the expression of a circumscribed set of genes (DISC1 Regulome) that are also implicated in brain biology and disorder. Here, we report targeted sequencing of 59 DISC1 Interactome genes and 154 Regulome genes in 654 psychiatric patients and 889 cognitively-phenotyped control subjects, on whom we previously reported evidence for trait association from complete sequencing of the DISC1 locus. Burden analyses of rare and singleton variants predicted to be damaging were performed for psychiatric disorders, cognitive variables and personality traits. The DISC1 Interactome and Regulome showed differential association across the phenotypes tested. After family-wise error correction across all traits (FWERacross), an increased burden of singleton disruptive variants in the Regulome was associated with SCZ (FWERacrossP=0.0339). The burden of singleton disruptive variants in the DISC1 Interactome was associated with low cognitive ability at age 11 (FWERacrossP=0.0043). These results suggest that variants in the DISC1 Interactome effect the risk of psychiatric illness through altered expression of schizophrenia-associated genes. The biological impact of rare variants highlighted here merit further study.

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A Latent State-Trait Analysis of Current Achievement Motivation Across Different Tasks of Cognitive Ability

European Journal of Psychological Assessment ◽

10.1027/1015-5759/a000289 ◽

2017 ◽

Vol 33 (5) ◽

pp. 318-327

Author(s):

Philipp Alexander Freund ◽

Vanessa Katharina Jaensch ◽

Franzis Preckel

Keyword(s):

Cognitive Ability ◽

Task Performance ◽

Achievement Motivation ◽

Fear Of Failure ◽

Specific Task ◽

Test Taker ◽

Specific Interest ◽

Probability Of Success ◽

Ability Tests ◽

Perceived Challenge

Abstract. The current study investigates the behavior of task-specific, current achievement motivation (CAM: interest in the task, probability of success, perceived challenge, and fear of failure) across a variety of reasoning tasks featuring verbal, numerical, and figural content. CAM is conceptualized as a state-like variable, and in order to assess the relative stability of the four CAM variables across different tasks, latent state trait analyses are conducted. The major findings indicate that the degree of challenge a test taker experiences and the fear of failing a given task appear to be relatively stable regardless of the specific task utilized, whereas interest and probability of success are more directly influenced by task-specific characteristics and demands. Furthermore, task performance is related to task-specific interest and probability of success. We discuss the implications and benefits of these results with regard to the use of cognitive ability tests in general. Importantly, taking motivational differences between test takers into account appears to offer valuable information which helps to explain differences in task performance.

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Sex Differences in Childhood Associations between DNA Markers and General Cognitive Ability

Journal of Individual Differences ◽

10.1027/1614-0001.28.3.161 ◽

2007 ◽

Vol 28 (3) ◽

pp. 161-164 ◽

Cited By ~ 1

Author(s):

Rosalind Arden ◽

Nicole Harlaar ◽

Robert Plomin

Keyword(s):

Sex Differences ◽

Single Nucleotide Polymorphisms ◽

Cognitive Ability ◽

Dna Markers ◽

Community Sample ◽

Nucleotide Polymorphisms ◽

General Cognitive Ability ◽

Single Nucleotide ◽

The Difference

Abstract. An association between intelligence at age 7 and a set of five single-nucleotide polymorphisms (SNPs) has been identified and replicated. We used this composite SNP set to investigate whether the associations differ between boys and girls for general cognitive ability at ages 2, 3, 4, 7, 9, and 10 years. In a longitudinal community sample of British twins aged 2-10 (n > 4,000 individuals), we found that the SNP set is more strongly associated with intelligence in males than in females at ages 7, 9, and 10 and the difference is significant at 10. If this finding replicates in other studies, these results will constitute the first evidence of the same autosomal genes acting differently on intelligence in the two sexes.

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A Meta-Analysis of Interviews and Cognitive Ability

Journal of Personnel Psychology ◽

10.1027/1866-5888/a000091 ◽

2013 ◽

Vol 12 (4) ◽

pp. 157-169 ◽

Cited By ~ 7

Author(s):

Philip L. Roth ◽

Allen I. Huffcutt

Keyword(s):

Cognitive Ability ◽

Meta Analysis ◽

Incremental Validity ◽

Employment Interviews ◽

Moderator Analysis ◽

The Future ◽

Research Questions ◽

Meta Analyses ◽

The Relationship

The topic of what interviews measure has received a great deal of attention over the years. One line of research has investigated the relationship between interviews and the construct of cognitive ability. A previous meta-analysis reported an overall corrected correlation of .40 ( Huffcutt, Roth, & McDaniel, 1996 ). A more recent meta-analysis reported a noticeably lower corrected correlation of .27 ( Berry, Sackett, & Landers, 2007 ). After reviewing both meta-analyses, it appears that the two studies posed different research questions. Further, there were a number of coding judgments in Berry et al. that merit review, and there was no moderator analysis for educational versus employment interviews. As a result, we reanalyzed the work by Berry et al. and found a corrected correlation of .42 for employment interviews (.15 higher than Berry et al., a 56% increase). Further, educational interviews were associated with a corrected correlation of .21, supporting their influence as a moderator. We suggest a better estimate of the correlation between employment interviews and cognitive ability is .42, and this takes us “back to the future” in that the better overall estimate of the employment interviews – cognitive ability relationship is roughly .40. This difference has implications for what is being measured by interviews and their incremental validity.

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A Multimedia Situational Test With a Constructed-Response Format

Journal of Personnel Psychology ◽

10.1027/1866-5888/a000035 ◽

2011 ◽

Vol 10 (2) ◽

pp. 78-88 ◽

Cited By ~ 18

Author(s):

Janneke K. Oostrom ◽

Marise Ph. Born ◽

Alec W. Serlie ◽

Henk T. van der Molen

Keyword(s):

Cognitive Ability ◽

Computer Technology ◽

Psychology Students ◽

Learning Activities ◽

Ability Test ◽

Constructed Response ◽

Job Experience ◽

Relationship Of ◽

The Relationship ◽

Situational Test

Advances in computer technology have created opportunities for the development of a multimedia situational test in which responses are filmed with a webcam. This paper examined the relationship of a so-called webcam test with personality, cognitive ability, job experience, and academic performance. Data were collected among 153 psychology students. In line with our expectations, scores on the webcam test, intended to measure interpersonally oriented leadership, were related to extraversion, conscientiousness, emotional stability, and job experience. Furthermore, the webcam tests significantly predicted students’ learning activities during group meetings over and above a cognitive ability test and a personality questionnaire. Overall, this study demonstrates that webcam tests can be a valid complement to traditional predictors in selection contexts.

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