Development of a mathematical model for the growth associated Polyhydroxybutyrate fermentation by Azohydromonas australica and its use for the design of fed-batch cultivation strategies

2013 ◽  
Vol 137 ◽  
pp. 98-105 ◽  
Author(s):  
Geeta Gahlawat ◽  
Ashok K. Srivastava
Keyword(s):  
Mathematical Model ◽  
Batch Cultivation ◽  
Fed Batch ◽  
Azohydromonas Australica ◽  
Fed Batch Cultivation

Segregated mathematical model for the fed-batch cultivation of a high-producing strain of Penicillium chrysogenum

1994 ◽  
Vol 34 (2) ◽  
pp. 119-131 ◽  
Author(s):  
Volker Tiller ◽  
Juliane Meyerhoff ◽  
Ditmar Sziele ◽  
Karl Schügerl ◽  
Karl-Heinz Bellgardt
Keyword(s):  
Mathematical Model ◽  
Penicillium Chrysogenum ◽  
Batch Cultivation ◽  
Fed Batch ◽  
Fed Batch Cultivation

scholarly journals A structured mathematical model of PHA biopolymer production process

2013 ◽  
Vol 23 (3) ◽  
pp. 351-360 ◽  
Author(s):  
Jana Finkeová ◽  
Pavel Hrnčiřík ◽  
Jan Mareš ◽  
Jaroslav Vovsík ◽  
Ondřej Hudeček ◽  
...  
Keyword(s):  
Experimental Data ◽  
Mathematical Model ◽  
Production Process ◽  
Octanoic Acid ◽  
Batch Cultivation ◽  
Model Parameters ◽  
Mass Balances ◽  
Fed Batch ◽  
Fed Batch Cultivation ◽  
Good Agreement

Abstract The paper describes a mathematical model of PHA biopolymer production process by Pseudomonas putida KT2442 where the octanoic acid is used as a substrate. The process is modeled using mass balances for fed-batch cultivation. Proper fitting to experimental data is obtained by identification of the model parameters. The model exhibits good agreement with experiments and its possible application for control is considered in the paper.

scholarly journals Optimization of Synthetic Media Composition for Kluyveromyces marxianus Fed-Batch Cultivation

Fermentation ◽  
2021 ◽  
Vol 7 (2) ◽  
pp. 62
Author(s):  
Konstantins Dubencovs ◽  
Janis Liepins ◽  
Arturs Suleiko ◽  
Anastasija Suleiko ◽  
Reinis Vangravs ◽  
...  
Keyword(s):  
Kluyveromyces Marxianus ◽  
Reaction Medium ◽  
Value Added ◽  
Batch Cultivation ◽  
Batch Processes ◽  
Biomass Growth ◽  
High Cell ◽  
Media Composition ◽  
Fed Batch ◽  
Fed Batch Cultivation

The Kluyveromyces marxianus yeast recently has gained considerable attention due to its applicability in high-value-added product manufacturing. In order to intensify the biosynthesis rate of a target product, reaching high biomass concentrations in the reaction medium is mandatory. Fed-batch processes are an attractive and efficient way how to achieve high cell densities. However, depending on the physiology of the particular microbial strain, an optimal media composition should be used to avoid by-product synthesis and, subsequently, a decrease in overall process effi-ciency. Thus, the aim of the present study was to optimise the synthetic growth medium and feeding solution compositions (in terms of carbon, nitrogen, phosphorous, magnesium, and calcium concentrations) for high cell density K. marxianus fed‑batch cultivations. Additionally, the biomass yields from the vitamin mixture and other macro/microelements were identified. A model predictive control algorithm was successfully applied for a fed-batch cultivation control. Biomass growth and substrate consumption kinetics were compared with the mathematical model predictions. Finally, 2‑phenylethanol biosynthesis was induced and its productivity was estimated. The determined optimal macronutrient ratio for K. marxianus biomass growth was identified as C:N:P = 1:0.07:0.011. The maximal attained yeast biomass concentration was close to 70 g·L-1 and the 2-PE biosynthesis rate was 0.372 g·L−1·h−1, with a yield of 74% from 2-phenylalanine.

scholarly journals Xylitol production by Candida parapsilosis under fed-batch culture

2001 ◽  
Vol 44 (2) ◽  
pp. 125-128 ◽  
Author(s):  
Sandra A. Furlan ◽  
Heizir F. de Castro
Keyword(s):  
Candida Parapsilosis ◽  
Batch Cultivation ◽  
Xylitol Production ◽  
Fed Batch ◽  
Substrate Consumption ◽  
Feed Medium ◽  
Fed Batch Culture ◽  
Rates Of Growth ◽  
Fed Batch Cultivation ◽  
Single Batch

Xylitol production by Candida parapsilosis was investigated under fed-batch cultivation, using single (xylose) or mixed (xylose and glucose) sugars as substrates. The presence of glucose in the medium induced the production of ethanol as secondary metabolite and improved specific rates of growth, xylitol formation and substrate consumption. Fractionated supply of the feed medium at constant sugar concentration did not promote any increase on the productivity compared to the single batch cultivation.

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