Increasing production of agricultural waste impacts health, economic, and environmental welfare. Thermophilic anaerobic digestion is a technology developed to treat these waste streams whereby the organic material is converted to biogas and effluent. The effluent, available in solid and liquid form, holds promise as a fertilizer. Digested (broiler litter) liquid effluent was compared to chemical and certified organic fertilizers with application rates based on soil analyses and crop recommendations. An unfertilized control and an effluent treatment at twice the recommended amount were also included. Beds treated with liquid effluent maintained higher levels of available phosphorus established from treatment in prior years with solid effluent. Beds treated with liquid effluent showed a significant increase in K, Mg, Cu, and Mn. Potato fresh weight and tuber number for 2× effluent beds were significantly better than the other treatments. Average tuber weight was also statistically significant, but organic, 2×, and 1× effluent were best. For tomato, the 2× effluent treatment was statistically better for fruit number, average weight, and total weight. In fact, the total weight per plant for the 2× effluent treatment was more than three times higher than the other fertilizer treatments. The chemical and effluent treatments were statistically better for broccoli than the organic or unfertilized control. Blueberry yields were not significantly different between treatments. As this is a perennial crop, it may be several years before a significant difference is observed. While not a total solution, our research shows the effectiveness of digested poultry litter as part of a nutrient management program, thereby making a safer, less-polluting alternative to raw livestock residuals.