An efficient approach to obtaining water-compatible and stimuli-responsive molecularly imprinted polymers by the facile surface-grafting of functional polymer brushes via RAFT polymerization

2010 ◽  
Vol 26 (3) ◽  
pp. 976-982 ◽  
Author(s):  
Guoqing Pan ◽  
Ying Zhang ◽  
Xianzhi Guo ◽  
Chenxi Li ◽  
Huiqi Zhang
Keyword(s):  
Molecularly Imprinted Polymers ◽  
Polymer Brushes ◽  
Raft Polymerization ◽  
Surface Grafting ◽  
Stimuli Responsive ◽  
Molecularly Imprinted ◽  
Functional Polymer ◽  
Imprinted Polymers ◽  
Efficient Approach

scholarly journals Advances in Molecularly Imprinted Polymers as Drug Delivery Systems

Molecules ◽  
2021 ◽  
Vol 26 (12) ◽  
pp. 3589
Author(s):  
Rui Liu ◽  
Alessandro Poma
Keyword(s):  
Drug Delivery ◽  
Molecularly Imprinted Polymers ◽  
Drug Loading ◽  
Stimuli Responsive ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Drug Delivery Vehicles ◽  
The Past ◽  
Drug Molecules ◽  
Delivery Vehicles

Despite the tremendous efforts made in the past decades, severe side/toxic effects and poor bioavailability still represent the main challenges that hinder the clinical translation of drug molecules. This has turned the attention of investigators towards drug delivery vehicles that provide a localized and controlled drug delivery. Molecularly imprinted polymers (MIPs) as novel and versatile drug delivery vehicles have been widely studied in recent years due to the advantages of selective recognition, enhanced drug loading, sustained release, and robustness in harsh conditions. This review highlights the design and development of strategies undertaken for MIPs used as drug delivery vehicles involving different drug delivery mechanisms, such as rate-programmed, stimuli-responsive and active targeting, published during the course of the past five years.

Preparation of molecularly imprinted polymers based on magnetic carbon nanotubes for determination of sulfamethoxazole in food samples

RSC Advances ◽  
2015 ◽  
Vol 5 (86) ◽  
pp. 70309-70318 ◽  
Author(s):  
Yingran Zhao ◽  
Changfen Bi ◽  
Xiwen He ◽  
Langxing Chen ◽  
Yukui Zhang
Keyword(s):  
Carbon Nanotubes ◽  
Molecularly Imprinted Polymers ◽  
Food Samples ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Efficient Approach ◽  
Magnetic Carbon ◽  
Magnetic Carbon Nanotubes

An efficient approach was developed to synthesize the imprinted magnetic carbon nanotubes nanocomposite and apply for sulfamethoxazole enrichment from milk and honey samples.

scholarly journals Molecularly Imprinted Polymers with Stimuli-Responsive Affinity: Progress and Perspectives

Polymers ◽  
2015 ◽  
Vol 7 (9) ◽  
pp. 1689-1715 ◽  
Author(s):  
Wei Chen ◽  
Yue Ma ◽  
Jianmin Pan ◽  
Zihui Meng ◽  
Guoqing Pan ◽  
...  
Keyword(s):  
Molecularly Imprinted Polymers ◽  
Stimuli Responsive ◽  
Molecularly Imprinted ◽  
Imprinted Polymers

scholarly journals Molecularly Imprinted Polymers for Dispersive (Micro)Solid Phase Extraction: A Review

Separations ◽  
2021 ◽  
Vol 8 (7) ◽  
pp. 99
Author(s):  
G. D. Thilini Madurangika Jayasinghe ◽  
Antonio Moreda-Piñeiro
Keyword(s):  
Solid Phase Extraction ◽  
Molecularly Imprinted Polymers ◽  
Solid Phase ◽  
Raft Polymerization ◽  
Phase Extraction ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Advantages And Disadvantages ◽  
Reversible Addition ◽  
Metal Framework

The review describes the development of batch solid phase extraction procedures based on dispersive (micro)solid phase extraction with molecularly imprinted polymers (MIPs) and magnetic MIPs (MMIPs). Advantages and disadvantages of the various MIPs for dispersive solid phase extraction and dispersive (micro)solid phase extraction are discussed. In addition, an effort has also been made to condense the information regarding MMIPs since there are a great variety of supports (magnetite and magnetite composites with carbon nanotubes, graphene oxide, or organic metal framework) and magnetite surface functionalization mechanisms for enhancing MIP synthesis, including reversible addition−fragmentation chain-transfer (RAFT) polymerization. Finally, drawbacks and future prospects for improving molecularly imprinted (micro)solid phase extraction (MIMSPE) are also appraised.

scholarly journals Development of Water-Compatible Molecularly Imprinted Polymers Based on Functionalized β-Cyclodextrin for Controlled Release of Atropine

Polymers ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 130 ◽  
Author(s):  
Yahui He ◽  
Shaomei Zeng ◽  
A. M. Abd El-Aty ◽  
Ahmet Hacımüftüoğlu ◽  
Woldemariam Kalekristos Yohannes ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Molecularly Imprinted Polymers ◽  
Isotherm Models ◽  
Template Molecule ◽  
Stimuli Responsive ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Potential Applications

Herein, a novel method for molecularly imprinted polymers (MIPs) using methacrylic acid functionalized beta-cyclodextrin (MAA-β-CD) monomer is presented, which was designed as a potential water-compatible composite for the controlled release of atropine (ATP). The molecularly imprinted microspheres with pH-sensitive characteristics were fabricated using thermally-initiated precipitation polymerization, employing ATP as a template molecule. The effects of different compounds and concentrations of cross-linking agents were systematically investigated. Uniform microspheres were obtained when the ratio between ATP, MAA-β-CD, and trimethylolpropane trimethacrylate (TRIM) was 1:4:20 (mol/mol/mol) in polymerization system. The ATP loading equilibrium data was best suited to the Freundlich and Langmuir isotherm models. The in vitro drug release study was assessed under simulated oral administration conditions (pH 1.5 and 7.4). The potential usefulness of MIPs as drug delivery devices are much better than non-molecularly imprinted polymers (NIPs). The study shows that the prepared polymers are a pH stimuli-responsive system, which controlled the release of ATP, indicating the potential applications in the field of drug delivery.

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