Mechanistic studies of dinucleotide and oligonucleotide model cyclobutane pyrimidine dimer (CPD) DNA lesions under alkaline conditions

2021 ◽  
pp. 116499
Author(s):  
Ritu Chaturvedi ◽  
Eric C. Long
Keyword(s):  
Dna Lesions ◽  
Pyrimidine Dimer ◽  
Cyclobutane Pyrimidine Dimer ◽  
Mechanistic Studies ◽  
Alkaline Conditions

scholarly journals Effect of Damage Type on Stimulation of Human Excision Nuclease by SWI/SNF Chromatin Remodeling Factor

2003 ◽  
Vol 23 (12) ◽  
pp. 4121-4125 ◽  
Author(s):  
Ryujiro Hara ◽  
Aziz Sancar
Keyword(s):  
Chromatin Remodeling ◽  
Dna Lesions ◽  
Pyrimidine Dimer ◽  
Cyclobutane Pyrimidine Dimer ◽  
Nucleosomal Dna ◽  
Different Types ◽  
Damage Type ◽  
Low Rate ◽  
Stimulation Of

ABSTRACT To investigate the repair of different types of DNA lesions in chromatin, we prepared mononucleosomes containing an acetylaminofluorene-guanine adduct (AAF-G), a (6-4) photoproduct, or a cyclobutane pyrimidine dimer (CPD) and measured the repair of these lesions by reconstituted 6-factor human excision nuclease. We find that incorporation into nucleosomes inhibits the repair of CPD more severely than repair of the AAF-G adduct and the (6-4) photoproduct. Equally important, we find that SWI/SNF stimulates the removal of AAF-G and (6-4) photoproduct but not of CPD from nucleosomal DNA. These results shed new light on the low rate of repair of CPDs in human cells in vivo.

Multiple Electronic and Structural Factors Control Cyclobutane Pyrimidine Dimer and 6-4 Thymine-Thymine Photodimerization in a DNA Duplex

2017 ◽  
Vol 23 (60) ◽  
pp. 15177-15188 ◽  
Author(s):  
Irene Conti ◽  
Lara Martínez-Fernández ◽  
Luciana Esposito ◽  
Siegfried Hofinger ◽  
Artur Nenov ◽  
...  
Keyword(s):  
Pyrimidine Dimer ◽  
Structural Factors ◽  
Cyclobutane Pyrimidine Dimer ◽  
Dna Duplex

Blockage of RNA polymerase II at a cyclobutane pyrimidine dimer and 6–4 photoproduct

2004 ◽  
Vol 320 (4) ◽  
pp. 1133-1138 ◽  
Author(s):  
Joan Seah Mei Kwei ◽  
Isao Kuraoka ◽  
Katsuyoshi Horibata ◽  
Manabu Ubukata ◽  
Eiry Kobatake ◽  
...  
Keyword(s):  
Rna Polymerase ◽  
Rna Polymerase Ii ◽  
Pyrimidine Dimer ◽  
Cyclobutane Pyrimidine Dimer
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