A 4-aminobenzoic acid derivative as novel lead for selective inhibitors of multidrug resistance-associated proteins

2008 ◽  
Vol 18 (17) ◽  
pp. 4761-4763 ◽  
Author(s):  
Stefan Leyers ◽  
Hans-Georg Häcker ◽  
Jeanette Wiendlocha ◽  
Michael Gütschow ◽  
Michael Wiese
Keyword(s):  
Multidrug Resistance ◽  
Acid Derivative ◽  
Aminobenzoic Acid ◽  
Selective Inhibitors ◽  
Associated Proteins

ChemInform Abstract: A 4-Aminobenzoic Acid Derivative as Novel Lead for Selective Inhibitors of Multidrug Resistance-Associated Proteins.

ChemInform ◽  
2009 ◽  
Vol 40 (1) ◽  
Author(s):  
Stefan Leyers ◽  
Hans-Georg Haecker ◽  
Jeanette Wiendlocha ◽  
Michael Guetschow ◽  
Michael Wiese
Keyword(s):  
Multidrug Resistance ◽  
Acid Derivative ◽  
Aminobenzoic Acid ◽  
Selective Inhibitors ◽  
Associated Proteins

Hormonal regulation of renal multidrug resistance-associated proteins 3 and 4 (Mrp3 and Mrp4) in mice

2006 ◽  
Vol 71 (10) ◽  
pp. 1470-1478 ◽  
Author(s):  
J.M. Maher ◽  
X. Cheng ◽  
Y. Tanaka ◽  
G.L. Scheffer ◽  
C.D. Klaassen
Keyword(s):  
Multidrug Resistance ◽  
Hormonal Regulation ◽  
Associated Proteins

scholarly journals Cannabinoid Type 1 Receptor Antagonists Modulate Transport Activity of Multidrug Resistance-Associated Proteins MRP1, MRP2, MRP3, and MRP4

2011 ◽  
Vol 39 (7) ◽  
pp. 1294-1302 ◽  
Author(s):  
Hanneke G. M. Wittgen ◽  
Jeroen J. M. W. van den Heuvel ◽  
Petra H. H. van den Broek ◽  
Heike Dinter-Heidorn ◽  
Jan B. Koenderink ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Transport Activity ◽  
Receptor Antagonists ◽  
Cannabinoid Type 1 Receptor ◽  
Associated Proteins

scholarly journals Block of CFTR-dependent chloride currents by inhibitors of multidrug resistance-associated proteins

2007 ◽  
Vol 560 (2-3) ◽  
pp. 127-131 ◽  
Author(s):  
Tullia Diena ◽  
Raffaella Melani ◽  
Emanuela Caci ◽  
Nicoletta Pedemonte ◽  
Elvira Sondo ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Chloride Currents ◽  
Associated Proteins

scholarly journals Pharmacokinetic Alteration of Paclitaxel by Ferulic Acid Derivative

Pharmaceutics ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 593 ◽  
Author(s):  
Jaeok Lee ◽  
Song Wha Chae ◽  
LianJi Ma ◽  
So Yeon Lim ◽  
Sarah Alnajjar ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Ferulic Acid ◽  
Acid Derivative ◽  
Glycoprotein P ◽  
P Glycoprotein ◽  
Substrate Drug

P-glycoprotein (P-gp) is known to be involved in multidrug resistance (MDR) and modulation of pharmacokinetic (PK) profiles of substrate drugs. Here, we studied the effects of synthesized ferulic acid (FA) derivatives on P-gp function in vitro and examined PK alteration of paclitaxel (PTX), a well-known P-gp substrate drug by the derivative. Compound 5c, the FA derivative chosen as a significant P-gp inhibitor among eight FA candidates by in vitro results, increased PTX AUCinf as much as twofold versus the control by reducing PTX elimination in rats. These results suggest that FA derivative can increase PTX bioavailability by inhibiting P-gp existing in eliminating organs.

Contribution of multidrug resistance-associated proteins (MRPs) to the release of prostanoids from A549 cells

2013 ◽  
Vol 106 ◽  
pp. 37-44 ◽  
Author(s):  
Ayako Furugen ◽  
Hiroaki Yamaguchi ◽  
Nobuaki Tanaka ◽  
Narumi Shiida ◽  
Jiro Ogura ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
A549 Cells ◽  
Associated Proteins
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