Design, synthesis and biological evaluation of β-boswellic acid based HDAC inhibitors as inducers of cancer cell death

2014 ◽  
Vol 24 (19) ◽  
pp. 4729-4734 ◽  
Author(s):  
Simmi Sharma ◽  
Mudassier Ahmad ◽  
Javeed Ahmad Bhat ◽  
Arvind Kumar ◽  
Manjeet Kumar ◽  
...  
Keyword(s):  
Cell Death ◽  
Cancer Cell ◽  
Hdac Inhibitors ◽  
Biological Evaluation ◽  
Boswellic Acid ◽  
Design Synthesis ◽  
Cancer Cell Death ◽  
Synthesis And Biological Evaluation

scholarly journals Design, synthesis and biological evaluation of imidazopyridine–propenone conjugates as potent tubulin inhibitors

MedChemComm ◽  
2017 ◽  
Vol 8 (5) ◽  
pp. 1000-1006 ◽  
Author(s):  
Ibrahim Bin Sayeed ◽  
V. Lakshma Nayak ◽  
Mohd Adil Shareef ◽  
Neeraj Kumar Chouhan ◽  
Ahmed Kamal
Keyword(s):  
Antitumor Activity ◽  
Cell Lines ◽  
Cancer Cell ◽  
Human Cancer ◽  
Biological Evaluation ◽  
Human Cancer Cell ◽  
Design Synthesis ◽  
Human Cancer Cell Lines ◽  
Tubulin Inhibitors ◽  
Synthesis And Biological Evaluation

A library of imidazopyridine–propenone conjugates (8a–8u) were synthesized and evaluated for their antitumor activity against four human cancer cell lines.

Structure and property based design, synthesis and biological evaluation of γ-lactam based HDAC inhibitors

2011 ◽  
Vol 21 (4) ◽  
pp. 1218-1221 ◽  
Author(s):  
Eunhyun Choi ◽  
Chulho Lee ◽  
Jung Eun Park ◽  
Jeong Jea Seo ◽  
Misun Cho ◽  
...  
Keyword(s):  
Hdac Inhibitors ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Structure And Property ◽  
Synthesis And Biological Evaluation

scholarly journals Design, synthesis and biological evaluation of β-peptoid-capped HDAC inhibitors with anti-neuroblastoma and anti-glioblastoma activity

MedChemComm ◽  
2019 ◽  
Vol 10 (7) ◽  
pp. 1109-1115 ◽  
Author(s):  
Nina Reßing ◽  
Viktoria Marquardt ◽  
Christoph G. W. Gertzen ◽  
Andrea Schöler ◽  
Alexander Schramm ◽  
...  
Keyword(s):  
Hdac Inhibitors ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation

Novel β-peptoid-capped HDAC inhibitors with anti-neuroblastoma and anti-glioblastoma activity were synthesized.

scholarly journals Design, Synthesis, and Biological Evaluation of Dual c-Met/HDAC Inhibitors Bearing 2-Aminopyrimidine Scaffold

2020 ◽  
Vol 02 (03) ◽  
pp. e143-e149
Author(s):  
Qingwei Zhang ◽  
Guili Xu ◽  
Ya Bao ◽  
Minru Jiao ◽  
Jianqi Li
Keyword(s):  
Histone Deacetylase ◽  
Cell Lines ◽  
Hdac Inhibitors ◽  
Biological Evaluation ◽  
Antitumor Drugs ◽  
Design Synthesis ◽  
Ic50 Values ◽  
Hct 116 ◽  
Synthesis And Biological Evaluation ◽  
Antiproliferative Activities

AbstractA series of c-Met/histone deacetylase (HDAC) bifunctional inhibitors was designed and synthesized by merging pharmacophores of c-Met and HDAC inhibitors. Among them, the most potent compound, 2o, inhibited c-Met kinase and HDACs, with IC50 values of 9.0 and 31.6 nM, respectively, and showed efficient antiproliferative activities against both A549 and HCT-116 cancer cell lines with greater potency than an equimolar mixture of the respective inhibitors of the two enzymes: crizotinib and vorinostat (SAHA). Our study provided an efficient strategy for the discovery of multitargeted antitumor drugs.

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