The daily habitual in vivo strain history of a non-weight-bearing bone

Bone ◽  
2010 ◽  
Vol 46 (1) ◽  
pp. 196-202 ◽  
Author(s):  
W.C. de Jong ◽  
J.H. Koolstra ◽  
J.A.M. Korfage ◽  
L.J. van Ruijven ◽  
G.E.J. Langenbach
Keyword(s):  
Weight Bearing ◽  
Strain History ◽  
History Of

scholarly journals ​Evaluation of the Efficacy of Mobility Plus® in the Management of Osteoarthritis and Joint Inflammation in Canines

2021 ◽  
Author(s):  
K.C. Ashwath ◽  
G. Bhagwat Vishwanath ◽  
T. Santosh Kumar ◽  
Rangesh Paramesh
Keyword(s):  
Clinical Condition ◽  
Weight Bearing ◽  
Joint Inflammation ◽  
Complete Recovery ◽  
Joint Mobility ◽  
Condition Score ◽  
Joint Health ◽  
History Of ◽  
Analgesic Activities

Background: Joint health is very vital in canines. Immediate attention and diagnosis will help to prevent suffering in canines. This study was designed to evaluate the in vivo efficacy of the poly-herbal formulation Mobility Plus® for arthritis, inflammation and analgesic activities in canines. Methods: A total of 18 client-owned dogs with a history of joint inflammation, hip dysplasia and arthritis were selected (n = 18) and supplemented with one tablet of Mobility Plus® daily until complete recovery. The changes in assessment parameters scores, viz. lameness score, joint mobility score, pain on palpation score, weight-bearing score and the overall clinical condition score were evaluated. The results revealed that lameness, joint mobility, pain and weight-bearing scores significantly (p less than 0.001) decreased in dogs as early as day 15; hence, the overall clinical condition score also decreased significantly (p less than 0.001) as early as day 15 after Mobility Plus® supplementation. Result: Present study revealed that lameness, joint mobility, pain and weight-bearing scores significantly (p and lt; 0.001) decreased in dogs as early as day 15; hence, the overall clinical condition score also decreased significantly (p and lt; 0.001) as early as day 15 after Mobility Plus® supplementation. Supplementation of Mobility Plus® has antiarthritic and anti-inflammatory activities. Mobility Plus® could be recommended for the amelioration of joint inflammation and osteoarthritis conditions in canines.

Biological NMR Spectroscopy

1997 ◽  
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Nmr Spectroscopy ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
State Of The Art ◽  
Critical Assessment ◽  
Resonance Spectroscopy ◽  
History Of ◽  
Structure Of Proteins

This book presents a critical assessment of progress on the use of nuclear magnetic resonance spectroscopy to determine the structure of proteins, including brief reviews of the history of the field along with coverage of current clinical and in vivo applications. The book, in honor of Oleg Jardetsky, one of the pioneers of the field, is edited by two of the most highly respected investigators using NMR, and features contributions by most of the leading workers in the field. It will be valued as a landmark publication that presents the state-of-the-art perspectives regarding one of today's most important technologies.

A Useful Diagnostic Method for Drug-induced Pneumonitis

1994 ◽  
Vol 22 (03n04) ◽  
pp. 329-336 ◽  
Author(s):  
Akira Kawasaki ◽  
Yutaka Mizushima ◽  
Hitoshi Kunitani ◽  
Masanobu Kitagawa ◽  
Masashi Kobayashi
Keyword(s):  
Bronchoalveolar Lavage Fluid ◽  
Challenge Test ◽  
Lavage Fluid ◽  
Peripheral Blood Lymphocytes ◽  
Lymphocyte Stimulation Test ◽  
Drug Induced ◽  
Chief Complaints ◽  
History Of ◽  
Chest X Ray

A 51 year-old male was admitted to our hospital with chief complaints of fever, dry cough and dyspnea. Chest X -ray films and his history of taking Chinese medicine for liver dysfunction were suggestive of drug-induced pneumonitis. Lymphocyte stimulation test (LST) to causative Chinese medical drugs of Sho-saiko-to and Dai-saiko-to was negative with peripheral blood lymphocytes (PBL), but was positive with Iymphocytes from bronchoalveolar lavage fluid (BALF). In vivo challenge test for Sho-saiko-to was positive. The LST with BALF-lymphocytes proved to be very useful in making a diagnosis of drug-induced pneumonitis.

Stress Fractures in Royal Marine Recruits

1970 ◽  
Vol 56 (1) ◽  
pp. 78-91
Author(s):  
J. Bertram
Keyword(s):  
Soft Tissue ◽  
Weight Bearing ◽  
Fracture Site ◽  
Stress Fractures ◽  
Vigorous Activity ◽  
Main Symptom ◽  
Soft Tissue Swelling ◽  
History Of ◽  
Radiological Changes

AbstractThe main features of stress fractures in Royal Marine recruits are that they occur in normal bones, most often those that are weight bearing. There is no history of injury, but there is usually a history of unaccustomed or more vigorous activity for some weeks before onset. The main symptom is pain on use of the affected part and this pain is relieved by rest. Localised tenderness and soft tissue swelling are present at the fracture site when the affected bone is readily palpable. Radiological changes are absent in the first seven to ten days, but become visible within two months, unless treatment starts or stress ceases early.

Severe Hemolytic Reaction Due to Anti-JK3

1999 ◽  
Vol 123 (10) ◽  
pp. 949-951
Author(s):  
Carol S. Marshall ◽  
Denis Dwyre ◽  
Robin Eckert ◽  
Liisa Russell
Keyword(s):  
The United States ◽  
Cell Phenotype ◽  
Prior History ◽  
Ethnic Variability ◽  
Hemolytic Transfusion Reaction ◽  
History Of ◽  
Rare Phenotype ◽  
Antibody Screen

Abstract A 35-year-old gravida 3, para 3 Filipino woman with a negative antibody screen, no prior history of transfusion, and no hemolytic disease of the newborn in her children suffered a massive postpartum hemorrhage requiring transfusion. A severe hemolytic transfusion reaction occurred 5 days after delivery. Subsequently, a panagglutinin on a routine antibody identification panel was identified as anti-Jk3. The patient's red blood cell phenotype was Jk(a−b−) and all of her children were Jk(a−b+), yet the antibody that formed reacted with equal strength against all Jka- or Jkb-positive cells. The rare Jk(a−b−) phenotype is more common in Polynesians. Anti-Jk3, like other Kidd system antibodies, is difficult to detect because in vivo production may be absent between provocative episodes and because these antibodies often show weak in vitro reactions. The increasing numbers of Pacific Islanders in the United States could result in more frequent encounters with this rare phenotype. Increased awareness of ethnic variability in blood phenotypes and of the capricious nature of Kidd antibodies can help pathologists and technologists deal more effectively with these cases.

scholarly journals [3H]proline incorporation and hydroxyproline concentration in articular cartilage during the development of osteoarthritis caused by immobilization. A study in vivo with rabbits

1981 ◽  
Vol 200 (2) ◽  
pp. 435-440 ◽  
Author(s):  
T Videman ◽  
I Eronen ◽  
T Candolin
Keyword(s):  
Total Protein ◽  
Collagen Synthesis ◽  
Weight Bearing ◽  
Specific Radioactivity ◽  
Collagen Content ◽  
Synthetic Activity ◽  
Synthesis Rate ◽  
Hydroxyproline Concentration ◽  
Proline Incorporation

Proline metabolism in vivo was studied during the development of immobilization osteoarthritis in rabbits. Collagen content was measured as the hydroxyproline concentration of the tissue in question. The incorporation of [3H]proline was used as the indicator for total protein synthesis; collagen synthesis rate was estimated from measurements of the specific radioactivity of hydroxyproline. Cartilage samples from knee and hip joints were analysed after 3, 7, 11, 18, 35 and 56 days of immobilization. The total protein and collagen synthesis rates of the immobilized legs increased and reached a maximum after 11-35 days. Although they decreased thereafter, these rates remained elevated to the end of the experiment. A slight increase in the synthetic activity of the non-immobilized contralateral legs was also detected after 7--18 days of immobilization. The isotope incorporation was markedly higher in tibial marginal tissue than in weight-bearing cartilage. In spite of the increased synthesis, no clear changes were found in the collagen content of the tissues studied during the experiment.

TRMmaintenance is regulated by tissue damage via P2RX7

2018 ◽  
Vol 3 (30) ◽  
pp. eaau1022 ◽  
Author(s):  
Regina Stark ◽  
Thomas H. Wesselink ◽  
Felix M. Behr ◽  
Natasja A. M. Kragten ◽  
Ramon Arens ◽  
...  
Keyword(s):  
T Cells ◽  
Cell Death ◽  
Tissue Damage ◽  
Extracellular Nucleotides ◽  
Critical Pathway ◽  
Rna Profiling ◽  
Molecular Pattern ◽  
History Of ◽  
Circulating T Cells

Tissue-resident memory T cells (TRM) are noncirculating immune cells that contribute to the first line of local defense against reinfections. Their location at hotspots of pathogen encounter frequently exposes TRM to tissue damage. This history of danger-signal exposure is an important aspect of TRM-mediated immunity that has been overlooked so far. RNA profiling revealed that TRM from liver and small intestine express P2RX7, a damage/danger-associated molecular pattern (DAMP) receptor that is triggered by extracellular nucleotides (ATP, NAD+). We confirmed that P2RX7 protein was expressed in CD8+ TRM but not in circulating T cells (TCIRC) across different infection models. Tissue damage induced during routine isolation of liver lymphocytes led to P2RX7 activation and resulted in selective cell death of TRM. P2RX7 activation in vivo by exogenous NAD+ led to a specific depletion of TRM while retaining TCIRC. The effect was absent in P2RX7-deficient mice and after P2RX7 blockade. TCR triggering down-regulated P2RX7 expression and made TRM resistant to NAD-induced cell death. Physiological triggering of P2RX7 by sterile tissue damage during acetaminophen-induced liver injury led to a loss of previously acquired pathogen-specific local TRM in wild-type but not in P2RX7 KO T cells. Our results highlight P2RX7-mediated signaling as a critical pathway for the regulation of TRM maintenance. Extracellular nucleotides released during infection and tissue damage could deplete TRM locally and free niches for new and infection-relevant specificities. This suggests that the recognition of tissue damage promotes persistence of antigen-specific over bystander TRM in the tissue niche.

scholarly journals Assessment of in vivo loading history of the patellofemoral joint: a study combining patellar position, tilt, alignment and bone SPECT/CT

2013 ◽  
Vol 22 (12) ◽  
pp. 3039-3046 ◽  
Author(s):  
Stephan N. Schön ◽  
Faik K. Afifi ◽  
Helmut Rasch ◽  
Felix Amsler ◽  
Niklaus F. Friederich ◽  
...  
Keyword(s):  
Patellofemoral Joint ◽  
Loading History ◽  
Patellar Position ◽  
History Of ◽  
Bone Spect ◽  
In Vivo Loading

In Vivo Tibiofemoral Contact Kinematics and Contact Forces During Dynamic Weight-Bearing Activities Following Total Knee Arthroplasty

2008 ◽  
Author(s):  
Kartik M. Varadarajan ◽  
Angela Moynihan ◽  
Darryl D’Lima ◽  
Clifford W. Colwell ◽  
Harry E. Rubash ◽  
...  
Keyword(s):  
Total Knee Arthroplasty ◽  
Knee Arthroplasty ◽  
Computational Models ◽  
Imaging System ◽  
Weight Bearing ◽  
Contact Forces ◽  
Inverse Dynamic ◽  
Contact Kinematics ◽  
Total Knee

Accurate knowledge of in vivo articular contact kinematics and contact forces is required to quantitatively understand factors limiting life of total knee arthroplasty (TKA) implants, such as polyethylene component wear and implant loosening [1]. Determination of in vivo tibiofemoral contact forces has been a challenging issue in biomechanics. Historically, instrumented tibial implants have been used to measure tibiofemoral forces in vitro [2] and computational models involving inverse dynamic optimization have been used to estimate joint forces in vivo [3]. Recently, D’Lima et al. reported the first in vivo measurement of 6DOF tibiofemoral forces via an instrumented implant in a TKA patient [4]. However this technique does not provide a direct estimation of tibiofemoral contact forces in the medial and lateral compartments. Recently, a dual fluoroscopic imaging system has been used to accurately determine tibiofemoral contact locations on the medial and lateral tibial polyethylene surfaces [5]. The objective of this study was to combine the dual fluoroscope technique and the instrumented TKAs to determine the dynamic 3D articular contact kinematics and contact forces on the medial and lateral tibial polyethylene surfaces during functional activities.

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