scholarly journals Pitching Single Focus Confocal Analysis One Photon at a Time with Bayesian Nonparametrics

2020 ◽  
Vol 118 (3) ◽  
pp. 353a
Author(s):  
Steve Presse
2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Meysam Tavakoli ◽  
Sina Jazani ◽  
Ioannis Sgouralis ◽  
Omer M. Shafraz ◽  
Sanjeevi Sivasankar ◽  
...  

Biometrika ◽  
2021 ◽  
Author(s):  
Lorenzo Masoero ◽  
Federico Camerlenghi ◽  
Stefano Favaro ◽  
Tamara Broderick

Abstract While the cost of sequencing genomes has decreased dramatically in recent years, this expense often remains non-trivial. Under a fixed budget, scientists face a natural trade-off between quantity and quality: spending resources to sequence a greater number of genomes or spending resources to sequence genomes with increased accuracy. Our goal is to find the optimal allocation of resources between quantity and quality. Optimizing resource allocation promises to reveal as many new variations in the genome as possible. In this paper, we introduce a Bayesian nonparametric methodology to predict the number of new variants in a follow-up study based on a pilot study. When experimental conditions are kept constant between the pilot and follow-up, we find that our prediction is competitive with the best existing methods. Unlike current methods, though, our new method allows practitioners to change experimental conditions between the pilot and the follow-up. We demonstrate how this distinction allows our method to be used for more realistic predictions and for optimal allocation of a fixed budget between quality and quantity.


1979 ◽  
Vol 16 (5) ◽  
pp. 574-582 ◽  
Author(s):  
J. J. Berman ◽  
J. M. Rice

A single intraperitoneal dose of methyl(acetoxymethyl)nitrosamine (13 mg/kg body weight) given to 78 5-week-old male rats induced 25 mesotheliomas; two mesotheliomas were found in 67 control rats. All mesotheliomas arose from the peritesticular mesothelium and had a typical microscopic appearance of branching papillary fronds with a collagenous core covered by one or many layers of plump tumor cells. Cytoplasm of tumor cells contained material that reacted positively to a colloidal iron stain and was labile to hyaluronidase. In addition to frank mesotheliomas, 16 lesions, which we called atypical mesothelial proliferations. were found. These consisted of a single focus of plump mesothelial cells overlying an area of thick stroma. Often these foci included short, non-branched papillary projections above the surface of adjacent normal mesothelium. Twelve of the 16 lesions occurred in methyl(acetoxymethyl)nitrosamine-treated rats.


The purpose of this memoir is to discover an optical appliance which shall correct in a practical manner the faults in the field of a Cassegrain reflector, while leaving unimpaired its achromatism and the characteristic features of its design, which gives a focal length much greater than the length of the instrument, combined with a convenient position of the observer. The question touches an investigation by Schwarzschild as to what can be done with two curved mirrors the figures of which are not necessarily spherical. With these be corrects spherical aberration and coma, but in order to secure a flat field he is led to a construction in which the second mirror, which is between the great mirror and its principal focus, is concave, and therefore shortens the effective focal length, in place of increasing it. The deformations from spherical figures are also so great, especially for the great mirror, as to leave it doubtful whether the construction discussed could ever be the model for practicable instruments. If we keep to the Cassegrain form, spherical aberration and coma may equally be corrected by deformations of the mirrors which through large, are less extreme, but there remains a pronounced curvature of the field. For this reason I am led, in the present memoir, to consider more complicated systems produced by the interposition of systems of lenses, achromatism can be preserved completely for a single focus if there are three lenses of focal length determined when their position are given, and if all are made of the same glass. One of these lenses, which I call the reverser, is silvered at the back and replaces the convex mirror; the other two are placed close together in the way of the outcoming beam, about one third of the distance from the great mirror to the reverser; the members of this pair, which I call the corrector, are of nearly equal but opposite focal lengths, introducing very little deviation in the ray but an arbitrary amount of aberration, according to the distribution of curvatures between the two faces of each lens. All the surfaces are supposed spherical except that of the great mirror, The essential problem is to bring the necessary work into a form that will allow unknown quantities which express the distribution of curvature between the faces of each lens to be carried forward algebraically. The methods employed are those of a recent memoir by the author,* and a part of the paper is occupied in working out expressions to which this theory leads, for thin lenses, systems of thin lenses, mirrors, reversers and the like, and it may be regarded as an expansion and working illustration of that memoir. Ibis part does not lend itself to summary, When the expressions are obtained the solution proceeds in a straightforward manner, by approximation, which is somewhat complicated owing to the number of considerations which it is necessary to keep in view, but is not otherwise difficult. The solution is completed at the stage where the unextinguished aberrations are considered negligible.


2014 ◽  
Vol 79 (1) ◽  
pp. 37-53
Author(s):  
Jeroen de Ridder

Much of Alvin Plantinga’s Where the Conflict Really Lies(2011) will contain few surprises for those who have been following his work over the past decades. This —I hasten to add — is nothing against the book. The fact alone that his ideas on various topics, which have appeared scattered throughout the literature, are now actualized, applied to the debate about the (alleged) conflict between science and religion, and organized into an overarching argument with a single focus makes this book worthwhile. Moreover, I see this book making significant progress on two opposite ends of the spectrum of views about science and religion. On the one end, we find the so-called new atheists and other conflict-mongers. Compared to the overheated rhetoric that oozes from their writings, this book is a breath of fresh air. Plantinga cuts right to the chase and soberly exposes the bare bones of the new atheists’ arguments. It immediately becomes clear how embarrassingly bare these bones really are. On the other end of the spectrum are theologians and scientists who envisage harmony and concord between science and religion.


2011 ◽  
Vol 31 (2) ◽  
pp. 131-142 ◽  
Author(s):  
Dunlei Cheng ◽  
Adam J. Branscum ◽  
Wesley O. Johnson

2010 ◽  
Vol 84 (4) ◽  
pp. 440-444 ◽  
Author(s):  
P. Pepe ◽  
F. Fraggetta ◽  
A. Galia ◽  
G. Candiano ◽  
G. Grasso ◽  
...  

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