Changes in BAER amplitudes after perinatal asphyxia during the neonatal period in term infants

An analysis of the significant causes of death in 4117 consecutive births was made; there were 66 fetal deaths and 85 neonatal deaths. A significant cause of death was determined in 51 fetuses and 56 live-born infants. Eighty-five per cent of the live-born infants who weighed over 1000 gm. at birth and had postmortem examinations had causes of death which were considered to be significant. Almost half of the live-born premature infants with birth weights between 1000 and 2500 gm. were considered to have had more than one significant cause of death. The so-called significant causes of death among live-born infants differed from those determined for fetuses dying before birth. Among the former, pathologic conditions in the infants were determined four times more frequently than in those dying before birth and, in the latter, maternal complications of pregnancy and labor were diagnosed as significant causes of death five times more frequently than in infants dying in the neonatal period. Hyaline-like material in the lung was considered to be the most frequent significant cause of death in live-born premature infants; congenital malformation and anoxia resulting from complications of labor were the most frequently determined significant causes of death in live-born full term infants. No differences were found in the significant causes of death in premature and full term fetuses. Anoxia resulting from accidental and unexpected interruption of the blood flow in the placenta and umbilical cord and from dystocia was the most frequently determined significant cause of death in both groups. A plea has been made for the adoption by obstetricians, pathologists and pediatricians of a formal uniform plan of classifying the causes of fetal and neonatal death which would divest current efforts to determine the cause of death of as much vague terminology and arbitrary opinion as possible.

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Fluid restriction for term infants with hypoxic-ischaemic encephalopathy following perinatal asphyxia

Cochrane Database of Systematic Reviews ◽

10.1002/14651858.cd004337.pub2 ◽

2005 ◽

Cited By ~ 17

Author(s):

Zsuzsoka Kecskes ◽

Genevieve Healy ◽

Annika Jensen

Keyword(s):

Perinatal Asphyxia ◽

Fluid Restriction ◽

Term Infants

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Outcome of non-cooled asphyxiated infants with under-recognised or delayed-onset encephalopathy

Archives of Disease in Childhood - Fetal and Neonatal Edition ◽

10.1136/archdischild-2020-321331 ◽

2021 ◽

pp. fetalneonatal-2020-321331

Author(s):

Corline E J Parmentier ◽

Sylke J Steggerda ◽

Lauren C Weeke ◽

Monique Rijken ◽

Linda S De Vries ◽

...

Keyword(s):

Clinical Characteristics ◽

Adverse Outcome ◽

Perinatal Asphyxia ◽

Neurodevelopmental Outcome ◽

Intraventricular Haemorrhage ◽

Seizure Onset ◽

Mri Findings ◽

Term Infants ◽

Pattern Of Injury ◽

Near Term

ObjectiveTo describe the clinical characteristics, MRI findings and neurodevelopmental outcome of infants with documented perinatal asphyxia and seizure onset within 24 hours after birth who were not selected for therapeutic hypothermia (TH).DesignRetrospective cohort study.Setting and patients(Near-)term infants with documented perinatal asphyxia referred to two Dutch level III neonatal units with neonatal encephalopathy (NE) and seizures <24 hours after birth not treated with TH. Infants with a diagnosis other than NE following perinatal asphyxia causing the seizures were excluded.Main outcome measuresClinical characteristics, findings on cranial MRI performed within 8 days after birth and neurodevelopmental outcome assessed using the Griffiths Mental Development Scales at 18 months or Bayley Scales of Infant and Toddler Development–Third Edition at 2 years of age.Results39 infants were included. All had abnormalities on MRI. Predominant white matter/watershed injury was the most common pattern of injury, 23 (59%). 7 (18%) infants had predominant basal ganglia/thalamus injury, 3 (8%) near total brain injury, 5 (13%) arterial ischaemic stroke, 1 (3%) an intraventricular haemorrhage. Adverse outcome was seen in 51%: 6 died, 11 developed cerebral palsy (spastic n=8, dyskinetic n=3), 2 had neurodevelopmental delay, 1 had severe hearing impairment.ConclusionsAll infants with documented perinatal asphyxia and seizure onset within 24 hours after birth who did not receive TH had abnormalities on MRI. 51% had an adverse outcome. Better methods for recognition of infants who might benefit from TH and careful neurodevelopmental follow-up are urgently needed.

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Suprapubic Aspiration of Urine in Premature and Term Infants

PEDIATRICS ◽

10.1542/peds.36.1.132 ◽

1965 ◽

Vol 36 (1) ◽

pp. 132-134 ◽

Cited By ~ 1

Author(s):

JOHN D. NELSON ◽

PAUL C. PETERS

Keyword(s):

Urinary Bladder ◽

Neonatal Period ◽

Needle Aspiration ◽

Term Infants ◽

Urine Specimens ◽

Neonatal Infants

The purpose of this brief communication is to familiarize pediatricians with the advantages and ease of suprapubic needle aspiration of the urinary bladder in small infants when urine specimens for culture are needed. The technique has been used successfully in adults. Pryles et al. reported on percutaneous suprapubic aspiration of the bladder in 42 children, including 6 babies 3 to 6 months of age; however, use of this procedure in the neonatal period has not been previously reported. Contaminated urine specimens from neonatal infants are commonly encountered. We have studied 62 randomly selected, uncircumcised premature male infants. Using meticulous care in cleansing and handling of the specimens by the technique of Pryles et al.

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Maturational patterns of left ventricular rotational mechanics in pre-term infants through 1 year of age

Cardiology in the Young ◽

10.1017/s1047951120001912 ◽

2020 ◽

Vol 30 (9) ◽

pp. 1238-1246

Author(s):

Gloria C. Lehmann ◽

Philip T. Levy ◽

Meghna D. Patel ◽

Timothy Sekarski ◽

HongJie Gu ◽

...

Keyword(s):

Repeated Measures ◽

Neonatal Period ◽

Ductus Arteriosus ◽

Left Ventricular ◽

Term Infants ◽

Apical Rotation ◽

Cardiopulmonary Complications ◽

Rotational Mechanics ◽

The Impact ◽

Over Time

AbstractBackground:Pre-mature birth impacts left ventricular development, predisposing this population to long-term cardiovascular risk. The aims of this study were to investigate maturational changes in rotational properties from the neonatal period through 1 year of age and to discern the impact of cardiopulmonary complications of pre-maturity on these measures.Methods:Pre-term infants (<29 weeks at birth, n = 117) were prospectively enrolled and followed to 1-year corrected age. Left ventricular basal and apical rotation, twist, and torsion were measured by two-dimensional speckle-tracking echocardiography and analysed at 32 and 36 weeks post-menstrual age and 1-year corrected age. A mixed random effects model with repeated measures analysis was used to compare rotational mechanics over time. Torsion was compared in infants with and without complications of cardiopulmonary diseases of pre-maturity, specifically bronchopulmonary dysplasia, pulmonary hypertension, and patent ductus arteriosus.Results:Torsion decreased from 32 weeks post-menstrual age to 1-year corrected age in all pre-term infants (p < 0.001). The decline from 32 to 36 weeks post-menstrual age was more pronounced in infants with cardiopulmonary complications, but was similar to healthy pre-term infants from 36 weeks post-menstrual age to 1-year corrected age. The decline was due to directional and magnitude changes in apical rotation over time (p < 0.05).Conclusion:This study tracks maturational patterns of rotational mechanics in pre-term infants and reveals torsion declines from the neonatal period through 1 year. Cardiopulmonary diseases of pre-maturity may negatively impact rotational mechanics during the neonatal period, but the myocardium recovers by 1-year corrected age.

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Creatine kinase isoenzymes in serum from cord blood and the blood of healthy full-term infants during the first three postnatal days.

Clinical Chemistry ◽

10.1093/clinchem/28.2.317 ◽

1982 ◽

Vol 28 (2) ◽

pp. 317-322 ◽

Cited By ~ 18

Author(s):

R Jedeikin ◽

S K Makela ◽

A T Shennan ◽

R D Rowe ◽

G Ellis

Keyword(s):

Creatine Kinase ◽

Cord Blood ◽

Vaginal Delivery ◽

Neonatal Period ◽

Full Term ◽

Term Infants ◽

Skin Puncture ◽

Creatine Kinase Isoenzymes ◽

Cesarian Section

Abstract Isoenzymes of creatine kinase (ATP:creatine phosphotransferase; EC 2.7.3.2; CK) were measured by electrophoresis in serum from cord blood and skin-puncture blood taken from 45 healthy full-term infants during the first three postnatal days. Mean total CK activities (in U/L at 30 degrees C) were 185 in cord samples, 536 in samples taken between 5--8 h postnatally, 494 between 24--33 h, and 288 in the 72-100 h samples. Values for all three isoenzymes increased to a peak over this period, with the highest values generally being found in the samples taken 5--33 h after birth; the subsequent decline was most rapid for CK-BB. Serum CK isoenzymes in cord samples and those taken at 72--100 h in the 11 babies delivered by cesarian section did not differ significantly from those of babies delivered vaginally. However the postnatal increases in total CK, CK-MM, and CK-MB (but not in CK-BB) were significantly greater in those patients born by vaginal delivery. The reasons for the increases in CK isoenzymes after birth are not clear, but our results and reported studies on the ontogeny of CK suggest that CK-MB cannot be regarded as a "cardiac-specific" isoenzyme in the neonatal period.

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