Proteomic analysis reveals plasma haptoglobin, interferon-γ, and interleukin-1β as potential biomarkers of pediatric refractory epilepsy

2020 ◽  
Author(s):  
Vitchayaporn Emarach Saengow ◽  
Wararat Chiangjong ◽  
Chaiyos Khongkhatithum ◽  
Channarong Changtong ◽  
Daranee Chokchaichamnankit ◽  
...  
Keyword(s):  
Proteomic Analysis ◽  
Refractory Epilepsy ◽  
Interferon Γ ◽  
Interleukin 1Β ◽  
Potential Biomarkers ◽  
Plasma Haptoglobin

Skewed Abrogation of Tolerance to a Neo Self-Antigen in Double-Transgenic Mice Coexpressing the Antigen with Interleukin-1β or Interferon-γ

2001 ◽  
Vol 207 (1) ◽  
pp. 6-12 ◽  
Author(s):  
Meifen Zhang ◽  
Atsuki Fukushima ◽  
Barbara P. Vistica ◽  
Stephen J. Kim ◽  
Lang Hung ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Interferon Γ ◽  
Interleukin 1Β ◽  
Double Transgenic Mice ◽  
Self Antigen

scholarly journals Novel potential biomarkers for ST-elevation myocardial infarction identified by proteomic analysis of plasma-derived microparticles

2013 ◽  
Vol 34 (suppl 1) ◽  
pp. P460-P460
Author(s):  
P. Velez ◽  
A. Parguina ◽  
I. Rosa ◽  
L. Grigorian ◽  
R. Ocaranza ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Proteomic Analysis ◽  
St Elevation Myocardial Infarction ◽  
St Elevation ◽  
Potential Biomarkers

scholarly journals Influence of various treatment methods on the content of cytokines in saliva of patients with chronic sialadenitis

2018 ◽  
Vol 99 (4) ◽  
pp. 593-597
Author(s):  
S Z Aliev
Keyword(s):  
Comparison Group ◽  
Interleukin 2 ◽  
Interferon Γ ◽  
Interleukin 1Β ◽  
Comprehensive Treatment ◽  
Study Group ◽  
Local Immunotherapy ◽  
Chronic Sialadenitis ◽  
Cytokine Levels ◽  
Mixed Saliva

Aim. Study of the main cytokines (interleukin-1β and -2, interferon γ) in the mixed saliva from patients with chronic sialadenitis on the basic and comprehensive treatment dynamically. Methods. During the period of 2014 to 2017 we performed examination and treatment of patients with salivary gland diseases. Out of them we defined a group with chronic non-specific sialadenitis including 45 patients seen in the clinic in exacerbation. Patients in the comparison group received basic treatment. Patients in the study group additionally to conventional treatment were administered local immunotherapy. Measurement of cytokine levels in the oral fluid was performed in 45 patients with chronic sialadenitis in exacerbation and in 10 practically healthy subjects. Results. The level of interleukin-1β in saliva was found to be significantly increased before treatment (p <0.05). After the treatment interleukin-1β level in saliva decreased in both groups but most significantly this parameter decreased in the study group. After including local immunocorrection into the treatment complex dynamic decrease of interleukin-2 to 14.7±0.4 pg/ml was registered, which apparently is associated with stabilization of immune processes in the oral cavity. After the treatment conducted according to traditional scheme in the comparison group the level of interferon γ in saliva increased to 7.2±0.2 pg/ml which is 1.1 times higher than before treatment. Conclusion. In patients with chronic sialadenitis in exacerbation the level of interleukin-1β statistically significantly increases by 1. times (p <0.05), interleukin 2 - by 2.1 times (p <0.05) and the level of interferon γ decreases by 1.4 times (p <0.05) which is indicative of immunological signs of inflammatory reaction; use of local immunocorrection leads to more prominent decrease of interleukin-1β (by 20.3 vs 16.2% in comparison group; p <0.05), interleukin-2 (by 38.8 vs 26.6%; p <0.05) and increase of interferon γ (by 21.2 vs 12.5% in comparison group; p <0.05).

INTERFERON-γ AND INTERLEUKIN 4 INHIBIT INTERLEUKIN 1β-INDUCED DELAYED PROSTAGLANDIN E2GENERATION THROUGH SUPPRESSION OF CYCLOOXYGENASE-2 EXPRESSION IN HUMAN FIBROBLASTS

Cytokine ◽  
2000 ◽  
Vol 12 (6) ◽  
pp. 603-612 ◽  
Author(s):  
Yoshinori Hayashi ◽  
Makoto Kobayashi ◽  
Hiroshi Kuwata ◽  
Gen-ichi Atsumi ◽  
Katsutoshi Deguchi ◽  
...  
Keyword(s):  
Human Fibroblasts ◽  
Interferon Γ ◽  
Cyclooxygenase 2 ◽  
Interleukin 1Β ◽  
Interleukin 4

Proteomic analysis to identify plasma orosomucoid 2 and kinesin 18A as potential biomarkers of cholangiocarcinoma

2013 ◽  
Vol 12 (2) ◽  
pp. 81-95 ◽  
Author(s):  
Rucksak Rucksaken ◽  
Jarinya Khoontawad ◽  
Sittiruk Roytrakul ◽  
Porntip Pinlaor ◽  
Yusuke Hiraku ◽  
...  
Keyword(s):  
Proteomic Analysis ◽  
Potential Biomarkers

scholarly journals Cervicovaginal fluid proteomic analysis to identify potential biomarkers for preterm birth

2020 ◽  
Vol 222 (5) ◽  
pp. 493.e1-493.e13 ◽  
Author(s):  
Samuel Parry ◽  
Rita Leite ◽  
M. Sean Esplin ◽  
Radek Bukowski ◽  
Heping Zhang ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Proteomic Analysis ◽  
Potential Biomarkers ◽  
Cervicovaginal Fluid
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