Clinical Aspects and Electromagnetic Details of Low Field Magnetic Stimulation in Depression

Abstract Multiple sclerosis (MS) is the most well-known autoimmune disorder of the central nervous system, and constitutes a major cause of disability, especially in young individuals. A wide array of pharmacological treatments is available, but they have often been proven to be ineffective in ameliorating disease symptomatology or slowing disease progress. As such, non-invasive and non-pharmacological techniques have been gaining more ground. Transcranial magnetic stimulation (TMS) utilizes the electric field generated by a magnetic coil to stimulate neurons and has been applied, usually paired with electroencephalography, to study the underlying pathophysiology of MS, and in repetitive trains, in the form of repetitive transcranial magnetic stimulation (rTMS), to induce long-lasting changes in neuronal circuits. In this review, we present the available literature on the application of TMS and rTMS in the context of MS, with an emphasis on its therapeutic potential on various clinical aspects, while also naming the ongoing trials, whose results are anticipated in the future.

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259. NIRS Observation of Changes in Brain Activity following Low Field Magnetic Stimulation

Biological Psychiatry ◽

10.1016/j.biopsych.2017.02.273 ◽

2017 ◽

Vol 81 (10) ◽

pp. S106-S107 ◽

Cited By ~ 1

Author(s):

Michael Rohan ◽

Rinah Yamamoto ◽

Kyoko Ohashi ◽

Yunjie Tong ◽

Lia Hocke ◽

...

Keyword(s):

Magnetic Stimulation ◽

Brain Activity ◽

Low Field

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Low-field thoracic magnetic stimulation increases peripheral oxygen saturation levels in coronavirus disease (COVID-19) patients: a single-blind, sham-controlled, crossover study

10.1101/2021.05.21.21256456 ◽

2021 ◽

Author(s):

Saul M Dominguez-Nicolas ◽

Elias Manjarrez

Keyword(s):

Magnetic Flux ◽

Oxygen Saturation ◽

Crossover Study ◽

Magnetic Stimulation ◽

Controlled Study ◽

Magnetic Flux Density ◽

Peripheral Oxygen Saturation ◽

The Real ◽

Low Field ◽

Single Blind

The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) may cause low oxygen saturation (SpO2) and respiratory failure in coronavirus disease (COVID-19) patients. Hence the increase of SpO2 levels could be crucial for the quality of life and recovery of these patients. Here we introduce an electromagnetic device termed low-field thoracic magnetic stimulation (LF-ThMS) system. This device was designed to non-invasively deliver a pulsed magnetic field from 100 to 118 Hz and 10.5 to 13.1 mT (i.e., 105 to 131 Gauss) to the dorsal thorax. We show that these frequencies and magnetic flux densities are safe for the patients. We also present a proof-of-concept that a single session of LF-ThMS applied for 30 minutes to the dorsal thorax of 17 COVID-19 patients significantly increases their SpO2 levels. We designed a single-blind, sham-controlled, crossover study on 5 COVID-19 patients who underwent two sessions of the study (real and sham LF-ThMS) and 12 COVID-19 patients who underwent only the real LF-ThMS. We found a statistically significant correlation between magnetic flux density, frequency, or temperature associated with the real LF-ThMS and SpO2 levels in all COVID-19 patients. However, the five patients of the sham-controlled study did not exhibit a significant change in their SpO2 levels during sham stimulation. All the patients did not present adverse events after the LF-ThMS intervention.

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