A new phenylpropanoid glycoside from the bark of Streblus ilicifolius (Vidal) Corner

From the ethanol extract of Drynaria fortunei (KUNZE) J. Sm., a new phenylpropanoid glycoside, fortunamide (1), was isolated and characterized by spectroscopic methods. Together with a new glycoside, 9 known compounds, including three curcuminoids (2–4), two isoprenylated flavonoids (5, 6), two flavonoids (7, 8), one monoterpenoid (9) and one phenolic acid (10) were isolated and identified by spectral data analysis from the rhizomes of Drynaria fortunei (KUNZE) J. Sm. Eight of them were isolated from Drynaria fortunei (KUNZE) J. Sm. for the first time.

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Induction of Apoptotic Cell Death in HL-60 Cells by Acteoside, A Phenylpropanoid Glycoside.

Biological and Pharmaceutical Bulletin ◽

10.1248/bpb.21.81 ◽

1998 ◽

Vol 21 (1) ◽

pp. 81-83 ◽

Cited By ~ 23

Author(s):

Makoto INOUE ◽

Zentaro SAKUMA ◽

Yukio OGIHARA ◽

Iclal SARACOGLU

Keyword(s):

Cell Death ◽

Apoptotic Cell ◽

Apoptotic Cell Death ◽

Phenylpropanoid Glycoside

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Hypouricemic Effects of Phenylpropanoid Glycosides Acteoside ofScrophularia ningpoensison Serum Uric Acid Levels in Potassium Oxonate-Pretreated Mice

The American Journal of Chinese Medicine ◽

10.1142/s0192415x08005667 ◽

2008 ◽

Vol 36 (01) ◽

pp. 149-157 ◽

Cited By ~ 20

Author(s):

Cai Guo Huang ◽

Yan Jun Shang ◽

Jun Zhang ◽

Jian Rong Zhang ◽

Wen Jie Li ◽

...

Keyword(s):

Uric Acid ◽

Chinese Medicine ◽

Traditional Chinese Medicine ◽

Xanthine Oxidase ◽

Serum Uric Acid ◽

Mouse Liver ◽

Xanthine Dehydrogenase ◽

Phenylpropanoid Glycoside ◽

Phenylpropanoid Glycosides ◽

Potassium Oxonate

Phenylpropanoid glycoside acteoside was extracted from the traditional Chinese medicine Scrophularia ningpoenis Hemsl. In the present study, we investigated the effects of acteoside administration on serum uric acid levels in mice rendered hyperuricemic with the uricase inhibitor potassium oxonate. When administered orally for 3 days at doses of 50, 100 and 150 mg/kg, acteoside reduced serum uric acid levels by 15.2, 23.8 and 33.1%, respectively, relative to vehicle-treated hyperuricemic mice. Importantly, in non-hyperuricemic mice, the serum uric acid levels were not affected by acetoside treatment. Acteoside also inhibited mouse liver xanthine dehydrogenase XDH and xanthine oxidase XO activity at all three doses. These results suggest that the hypouricemic action of acteoside may be attributable to its inhibition of XDH/XO activity.

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A New Flavonoid Glycoside from Lysionotus pauciflorus

Natural Product Communications ◽

10.1177/1934578x1601100516 ◽

2016 ◽

Vol 11 (5) ◽

pp. 1934578X1601100

Author(s):

Wei Luo ◽

Yaya Wen ◽

Yanbei Tu ◽

Hongjian Du ◽

Qin Li ◽

...

Keyword(s):

Flavonoid Glycoside ◽

Spectroscopic Methods ◽

Phenylpropanoid Glycoside ◽

The Family ◽

First Time

Ten flavonoids (1–10), including a new glycoside (nevadensin-7-sambubioside, 7), together with a phenylpropanoid glycoside (11) were isolated from Lysionotus pauciflorus. Their structures were elucidated by a combination of spectroscopic methods and comparing with literature data. Five compounds (1, 3, 4, 8, and 9) were obtained from the family Gesneriaceae for the first time. The new compound was evaluated in vitro for anticholinesterase activities against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), but was found to be inactive.

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Induction of Cytokines by a Phenylpropanoid Glycoside Acteoside.

Biological and Pharmaceutical Bulletin ◽

10.1248/bpb.21.1394 ◽

1998 ◽

Vol 21 (12) ◽

pp. 1394-1395 ◽

Cited By ~ 8

Author(s):

Makoto INOUE ◽

Mari UEDA ◽

Yukio OGIHARA ◽

Iclal SARACOGLU

Keyword(s):

Phenylpropanoid Glycoside

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Four iridoid glucosides and a phenylpropanoid glycoside from Sesamum angolense

Phytochemistry ◽

10.1016/0031-9422(88)87042-0 ◽

1988 ◽

Vol 27 (8) ◽

pp. 2677-2679 ◽

Cited By ~ 27

Author(s):

Olivier Potterat ◽

Jerome D. Msonthi ◽

Kurt Hostettmann

Keyword(s):

Phenylpropanoid Glycoside ◽

Iridoid Glucosides

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Endoplasmic Reticulum Stress and NF-κB Pathway in Salidroside Mediated Neuroprotection: Potential of Salidroside in Neurodegenerative Diseases

The American Journal of Chinese Medicine ◽

10.1142/s0192415x17500793 ◽

2017 ◽

Vol 45 (07) ◽

pp. 1459-1475 ◽

Cited By ~ 5

Author(s):

Chenggui Wang ◽

Yiting Lou ◽

Jianxiang Xu ◽

Zhenhua Feng ◽

Yu Chen ◽

...

Keyword(s):

Nitric Oxide ◽

Endoplasmic Reticulum ◽

Endoplasmic Reticulum Stress ◽

Neurodegenerative Diseases ◽

Microglia Activation ◽

Phenylpropanoid Glycoside ◽

Bv2 Cells ◽

Protein Expressions ◽

Oxide Synthase ◽

Inducible Nitric Oxide

Microglial activation leads to increased production of proinflammatory enzymes and cytokines, which is considered to play crucial role in neurodegenerative diseases, however there are only a few drugs that target microglia activation. Recent studies have indicated that the Traditional Chinese Medicine, salidroside (Sal), exerted anti-inflammatory effects. According to this evidence, our present study aims to explore the effect of the Sal (a phenylpropanoid glycoside compound which is isolated from rhodiola), on microglia activation in lipopolysaccharide (LPS)-stimulated BV-2 cells. Our results showed that Sal could significantly inhibit the excessive production of Nitric Oxide (NO) and Prostaglandin E2 (PGE2) in LPS-stimulated BV2 cells. Moreover, Sal treatment could suppress the mRNA and protein expressions of inflammatory enzymes, including Inducible Nitric Oxide Synthase (iNOS) and Cyclooxygenase-2 (COX-2). The mechanisms may be related to the inhibition of the activation of Nuclear Factor-kappaB (NF-[Formula: see text]B) and endoplasmic reticulum stress. Our study demonstrated that salidroside could inhibit lipopolysaccharide-induced microglia activation via the inhibition of the NF-[Formula: see text]B pathway and endoplasmic reticulum stress, which makes it a promising therapeutic agent for human neurodegenerative diseases.

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