Corrigendum to “Electrospinning of carboxymethyl chitin/poly (vinyl alcohol) nanofibrous scaffolds for tissue engineering applications” [Carbohydr. Polym. 77 (2009) 863–869]

2020 ◽  
Vol 249 ◽  
pp. 116897
Author(s):  
K.T. Shalumon ◽  
N.S. Binulal ◽  
N. Selvamurugan ◽  
S.V. Nair ◽  
Deepthy Menon ◽  
...  
2009 ◽  
Vol 77 (4) ◽  
pp. 863-869 ◽  
Author(s):  
K.T. Shalumon ◽  
N.S. Binulal ◽  
N. Selvamurugan ◽  
S.V. Nair ◽  
Deepthy Menon ◽  
...  

Materials ◽  
2019 ◽  
Vol 12 (19) ◽  
pp. 3220
Author(s):  
Iuliana Samoila ◽  
Sorina Dinescu ◽  
Gratiela Gradisteanu Pircalabioru ◽  
Luminita Marutescu ◽  
Gheorghe Fundueanu ◽  
...  

Composite hydrogels based on pullulan (HP) and poly(vinyl alcohol) (PVA) were both prepared by simple chemical crosslinking with sodium trimethaphosphate (STMP) or by dual crosslinking (simultaneously chemical crosslinking with STMP and physical crosslinking by freeze-thaw technique). The resulting hydrogels and cryogels were designed for tissue engineering applications. PVA, with two different molecular weights (47,000 and 125,000 g/mol; PVA47 and PVA125, respectively), as well as different P/PVA weight ratios were tested. The physico-chemical characterization of the hydrogels was performed by FTIR spectroscopy and scanning electron microscopy (SEM). The swelling kinetics, dissolution behavior, and degradation profiles in simulated physiological conditions (phosphate buffer at pH 7.4) were investigated. Pullulan concentration and the crosslinking method had significant effects on the pore size, swelling ratio, and degradation profiles. Cryogels exhibit lower swelling capacities than the conventional hydrogels but have better stability against hydrolitic degradation. Biocompatibility of the hydrogels was also investigated by both MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) and LDH (lactaten dehydrogenase) assay. The MTT and LDH assays proved that dual crosslinked HP/PVA125 (75:25, w/w) scaffolds are more biocompatible and promote to a greater extent the adhesion and proliferation of L929 murine fibroblast cells than chemically crosslinked HP/PVA47 (50/50, w/w) scaffolds. Moreover, the HP/PVA125 cryogel had the best ability for the adipogenic differentiation of cells. The overall results demonstrated that the HP/PVA composite hydrogels or cryogels are suitable biomaterials for tissue engineering applications.


2019 ◽  
Vol 54 ◽  
pp. 101276 ◽  
Author(s):  
Keshaw R. Aadil ◽  
Akash Nathani ◽  
Chandra S. Sharma ◽  
Nibedita Lenka ◽  
Pratima Gupta

Polymers ◽  
2019 ◽  
Vol 12 (1) ◽  
pp. 7 ◽  
Author(s):  
Marta A. Teixeira ◽  
M. Teresa P. Amorim ◽  
Helena P. Felgueiras

Tissue engineering (TE) holds an enormous potential to develop functional scaffolds resembling the structural organization of native tissues, to improve or replace biological functions and prevent organ transplantation. Amongst the many scaffolding techniques, electrospinning has gained widespread interest because of its outstanding features that enable the production of non-woven fibrous structures with a dimensional organization similar to the extracellular matrix. Various polymers can be electrospun in the form of three-dimensional scaffolds. However, very few are successfully processed using environmentally friendly solvents; poly(vinyl alcohol) (PVA) is one of those. PVA has been investigated for TE scaffolding production due to its excellent biocompatibility, biodegradability, chemo-thermal stability, mechanical performance and, most importantly, because of its ability to be dissolved in aqueous solutions. Here, a complete overview of the applications and recent advances in PVA-based electrospun nanofibrous scaffolds fabrication is provided. The most important achievements in bone, cartilage, skin, vascular, neural and corneal biomedicine, using PVA as a base substrate, are highlighted. Additionally, general concepts concerning the electrospinning technique, the stability of PVA when processed, and crosslinking alternatives to glutaraldehyde are as well reviewed.


2012 ◽  
Vol 506 ◽  
pp. 359-362 ◽  
Author(s):  
T. Siritientong ◽  
Pornanong Aramwit

Silk sericin, a gumming protein from silk cocoons, has been a considerable natural protein-based biopolymer for fabrication of desired constructs for potential tissue engineering applications. This study investigated the formulation of a novel biopolymeric silk sericin/poly (vinyl alcohol) film with genipin as crosslinking agent and its physical properties. Silk sericin itself forms a fragile material, adding other polymers such as poly (vinyl alcohol) and glycerin, a plasticizer, resulting in a strong and flexible matrix. The results indicated that at higher concentration of genipin (0.1% w/v), the percentages of crosslinking in sericin/poly (vinyl alcohol) films was significantly higher. The matrices also exhibited higher tensile modulus value and higher elasticity at higher genipin concentration which can be inferred to higher integrity of the structure compared to matrices with genipin at low concentration (0.01% w/v). On the other hand, the reverse patterns were found in percentages of light transmission and the releasing profile of sericin from the composite films. Adding genipin into the matrices resulted in a lower percentage of light transmission indicated the increase in opacity. The releasing profile of sericin from the films showed that high genipin concentrations reduced the peak of protein released and trended to provide the sustain-released profile of protein. These findings indicated that silk sericin film can be formed and the concentrations of crosslinking agents really affect its physical properties.


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