Antioxidant effect of diphenyl diselenide against sodium nitroprusside (SNP) induced lipid peroxidation in human platelets and erythrocyte membranes: An in vitro evaluation

2006 ◽  
Vol 164 (1-2) ◽  
pp. 126-135 ◽  
Author(s):  
Thaís Posser ◽  
Maria Beatriz Moretto ◽  
Alcir Luiz Dafre ◽  
Marcelo Farina ◽  
João Batista Teixeira da Rocha ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Sodium Nitroprusside ◽  
Human Platelets ◽  
Antioxidant Effect ◽  
Erythrocyte Membranes ◽  
Diphenyl Diselenide ◽  
In Vitro Evaluation

scholarly journals Antioxidant Effect of a Polyphenol-Rich Murtilla (Ugni molinae Turcz.) Extract and Its Effect on the Regulation of Metabolism in Refrigerated Boar Sperm

2019 ◽  
Vol 2019 ◽  
pp. 1-15 ◽  
Author(s):  
Ignacio Jofré ◽  
Magdalena Cuevas ◽  
Leticia Signori de Castro ◽  
João Diego de Agostini Losano ◽  
Mariana Andrade Torres ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Sperm Motility ◽  
Sperm Quality ◽  
Membrane Damage ◽  
Antioxidant Effect ◽  
Boar Sperm ◽  
Fertilization Capacity ◽  
Ugni Molinae

The production of reactive oxygen species (ROS) in boar spermatozoa increases in refrigeration; this can have an impact on sperm quality and fertilization capacity. We evaluated the effect of polyphenol-rich aqueous extract of murtilla (Ugni molinae Turcz) on boar sperm stored at 17°C in order to reduce oxidative stress and improve sperm quality in the long term. Five experiments were performed: first, characterization of the polyphenol content from five genotypes of murtilla; second, determination of the genotype with the best antioxidant effect (MT-Ex); third, the antioxidant capacity on O2- and lipid peroxidation; fourth, the influence of MT-Ex on motility, calcium movement, cAMP, and metabolic parameters; and fifth, analysis of long-term refrigeration. The average phenolic content was 344 ppm; gallic acid, catechin, quercetin, myricetin, and kaempferol were detected. All extracts evaluated presented a concentration-dependent antioxidant effect. MT-Ex reduces intracellular O2-/peroxides but low lipid peroxidation. MT-Ex in nonstimulated ROS conditions reduces sperm motility, mitochondrial membrane potential, cAMP, and ATP, but the succinate dehydrogenase activity remained normal; also, we observed a reduction in calcium movement in in vitro sperm capacitation. The long-term analyses showed that MT-Ex improved sperm motility decay and reduced membrane damage and ROS at 168 h. Based on this study, we propose MT-Ex as a supplement in semen extenders.

Phenothiazine and phenoxazine derivatives of nafazatrom. In vitro evaluation as 5-lipoxygenase and iron-dependent lipid peroxidation inhibitors.

1992 ◽  
Vol 2 (1) ◽  
pp. 59-62
Author(s):  
Melvin J. Yu ◽  
Jefferson R. McCowan ◽  
Barbara Bertsch ◽  
Peter P.K. Ho ◽  
Lee A. Phebus ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
In Vitro Evaluation ◽  
Derivatives Of

Synthesis, Structure-activity Relationship and In Vitro Evaluation of Coelenterazine and Coelenteramine Derivatives as Inhibitors of Lipid Peroxidation

2003 ◽  
Vol 37 (2) ◽  
pp. 145-158 ◽  
Author(s):  
Maggi Burton ◽  
Catherine De Tollenaere ◽  
Jean-François Cavalier ◽  
Cécile Marchand ◽  
Frédérique Dussart ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
In Vitro Evaluation ◽  
Structure Activity
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