Chemically engineered mesoporous silica nanoparticles-based intelligent delivery systems for theranostic applications in multiple cancerous/non-cancerous diseases

2022 ◽  
Vol 452 ◽  
pp. 214309
Author(s):  
Shuai Zhou ◽  
Qin Zhong ◽  
Yang Wang ◽  
Po Hu ◽  
Wei Zhong ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Delivery Systems ◽  
Theranostic Applications

Recent Advances in Application of Azobenzenes Grafted on Mesoporous Silica Nanoparticles in Controlled Drug Delivery Systems Using Light as External Stimulus

2020 ◽  
Vol 20 (11) ◽  
pp. 1001-1016
Author(s):  
Sandra Ramírez-Rave ◽  
María Josefa Bernad-Bernad ◽  
Jesús Gracia-Mora ◽  
Anatoly K. Yatsimirsky
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Drug Delivery Systems ◽  
Mesoporous Silica Nanoparticles ◽  
High Surface ◽  
Delivery Systems ◽  
Surface Reactivity ◽  
External Stimulus ◽  
Recent Advances

Hybrid materials based on Mesoporous Silica Nanoparticles (MSN) have attracted plentiful attention due to the versatility of their chemistry, and the field of Drug Delivery Systems (DDS) is not an exception. MSN present desirable biocompatibility, high surface area values, and a well-studied surface reactivity for tailoring a vast diversity of chemical moieties. Particularly important for DDS applications is the use of external stimuli for drug release. In this context, light is an exceptional alternative due to its high degree of spatiotemporal precision and non-invasive character, and a large number of promising DDS based on photoswitchable properties of azobenzenes have been recently reported. This review covers the recent advances in design of DDS using light as an external stimulus mostly based on literature published within last years with an emphasis on usually overlooked underlying chemistry, photophysical properties, and supramolecular complexation of azobenzenes.

Selective functionalization of mesoporous silica nanoparticles with ibuprofen and Gd(iii) chelates: a new probe for potential theranostic applications

2015 ◽  
Vol 44 (41) ◽  
pp. 17927-17931 ◽  
Author(s):  
Fabio Carniato ◽  
Mónica Muñoz-Úbeda ◽  
Lorenzo Tei ◽  
Mauro Botta
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
External Surface ◽  
Mesoporous Silica Nanoparticles ◽  
Selective Functionalization ◽  
Theranostic Applications

Organo-modified mesoporous silica nanoparticles, loaded with ibuprofen into the pores and functionalized on the external surface with a stable Gd(iii)–DOTA-monoamide chelate, were prepared and explored as potential theranostic probes.

Recent Developments in Mesoporous Silica Nanoparticles for Tumor Theranostic Applications

2021 ◽  
Vol 27 ◽  
Author(s):  
Xuerui Wang ◽  
Mengyuan Zheng ◽  
Faizal Raza ◽  
Yuhao Liu ◽  
Yiqi Wei ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Tumor Therapy ◽  
Drug Carriers ◽  
Synthetic Methods ◽  
Medicine Research ◽  
Recent Developments ◽  
Theranostic Applications ◽  
Clinical Transformation

: Due to the advantages of adjustable pore size, easy surface modification, high biocompatibility, and so on, mesoporous silica nanoparticles (MSNs) have attracted lots of attention. And they are widely used in the fields of biology and medicine research, mostly focusing on drug and gene delivery and bioimaging. This review introduces several commonly used synthetic methods of MSNs and the latest progress of MSNs in tumor therapy and diagnosis, mainly including the study about modified MSNs as drug carriers and the application of MSNs in bioimaging. The deficiencies of MSNs’ application and prospects for its future clinical transformation are also discussed.

Polymeric Nanogels for Theranostic Applications: A Mini-Review

2020 ◽  
Vol 16 (3) ◽  
pp. 392-398 ◽  
Author(s):  
Vineeth M. Vijayan ◽  
Pradipika Natamai Vasudevan ◽  
Vinoy Thomas
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Metallic Nanoparticles ◽  
Functional Performance ◽  
Mesoporous Silica Nanoparticles ◽  
Review Article ◽  
Present Review ◽  
Theranostic Agents ◽  
Theranostic Applications ◽  
State Of Art

Theranostics is a recently emerging area in nanomedicine. Nanoparticles which can combine both diagnostic and therapy in one single platform serve as theranostic agents. Some of the currently explored nanoparticles are metallic nanoparticles, mesoporous silica nanoparticles, carbonbased nanoparticles, and polymer nanogels. Polymeric nanogels are receiving considerable attention due to their high biocompatibility and functional performance. The present review article briefly summarizes the scopes and challenges of the state of art of using polymeric nanogels for theranostic applications. Among the different polymer nanogels, a special emphasis is given to polymeric nanogels with innate imaging potential.

scholarly journals Mesoporous Silica Nanoparticles as Drug Delivery Systems for Targeted Inhibition of Notch Signaling in Cancer

2011 ◽  
Vol 19 (8) ◽  
pp. 1538-1546 ◽  
Author(s):  
Veronika Mamaeva ◽  
Jessica M Rosenholm ◽  
Laurel Tabe Bate-Eya ◽  
Lotta Bergman ◽  
Emilia Peuhu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Notch Signaling ◽  
Silica Nanoparticles ◽  
Drug Delivery Systems ◽  
Mesoporous Silica Nanoparticles ◽  
Delivery Systems ◽  
Targeted Inhibition

scholarly journals Oligonucleotide-capped mesoporous silica nanoparticles as DNA-responsive dye delivery systems for genomic DNA detection

2015 ◽  
Vol 51 (8) ◽  
pp. 1414-1416 ◽  
Author(s):  
Lluís Pascual ◽  
Isabel Baroja ◽  
Elena Aznar ◽  
Félix Sancenón ◽  
M. Dolores Marcos ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Genomic Dna ◽  
Dna Detection ◽  
Mesoporous Silica Nanoparticles ◽  
Delivery Systems

New hybrid oligonucleotide-capped mesoporous silica nanoparticles able to detect genomic DNA were designed.

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