Selective functionalization of mesoporous silica nanoparticles with ibuprofen and Gd(iii) chelates: a new probe for potential theranostic applications

2015 ◽  
Vol 44 (41) ◽  
pp. 17927-17931 ◽  
Author(s):  
Fabio Carniato ◽  
Mónica Muñoz-Úbeda ◽  
Lorenzo Tei ◽  
Mauro Botta

Organo-modified mesoporous silica nanoparticles, loaded with ibuprofen into the pores and functionalized on the external surface with a stable Gd(iii)–DOTA-monoamide chelate, were prepared and explored as potential theranostic probes.

2020 ◽  
Vol 22 (9) ◽  
Author(s):  
Shewaye Yismaw ◽  
Stefan G. Ebbinghaus ◽  
Marianne Wenzel ◽  
David Poppitz ◽  
Roger Gläser ◽  
...  

2021 ◽  
Vol 27 ◽  
Author(s):  
Xuerui Wang ◽  
Mengyuan Zheng ◽  
Faizal Raza ◽  
Yuhao Liu ◽  
Yiqi Wei ◽  
...  

: Due to the advantages of adjustable pore size, easy surface modification, high biocompatibility, and so on, mesoporous silica nanoparticles (MSNs) have attracted lots of attention. And they are widely used in the fields of biology and medicine research, mostly focusing on drug and gene delivery and bioimaging. This review introduces several commonly used synthetic methods of MSNs and the latest progress of MSNs in tumor therapy and diagnosis, mainly including the study about modified MSNs as drug carriers and the application of MSNs in bioimaging. The deficiencies of MSNs’ application and prospects for its future clinical transformation are also discussed.


2020 ◽  
Vol 16 (3) ◽  
pp. 392-398 ◽  
Author(s):  
Vineeth M. Vijayan ◽  
Pradipika Natamai Vasudevan ◽  
Vinoy Thomas

Theranostics is a recently emerging area in nanomedicine. Nanoparticles which can combine both diagnostic and therapy in one single platform serve as theranostic agents. Some of the currently explored nanoparticles are metallic nanoparticles, mesoporous silica nanoparticles, carbonbased nanoparticles, and polymer nanogels. Polymeric nanogels are receiving considerable attention due to their high biocompatibility and functional performance. The present review article briefly summarizes the scopes and challenges of the state of art of using polymeric nanogels for theranostic applications. Among the different polymer nanogels, a special emphasis is given to polymeric nanogels with innate imaging potential.


Nanoscale ◽  
2015 ◽  
Vol 7 (6) ◽  
pp. 2199-2209 ◽  
Author(s):  
Nikola Ž. Knežević ◽  
Jean-Olivier Durand

Large pore-mesoporous silica nanoparticles and their core/shell magnetic analogues are capable of loading and intracellular delivery of various biomolecules for theranostic applications.


2013 ◽  
Vol 1 (25) ◽  
pp. 3128 ◽  
Author(s):  
Nai-Tzu Chen ◽  
Shih-Hsun Cheng ◽  
Jeffrey S. Souris ◽  
Chin-Tu Chen ◽  
Chung-Yuan Mou ◽  
...  

2018 ◽  
Vol 41 (5) ◽  
Author(s):  
Varuna Kumaravel ◽  
Kartikeyan Damodaran ◽  
Sakthivel Gandhi ◽  
Uma Maheswari Krishnan

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