The effects of intermittent calorie restriction on metabolic health: Rationale and study design of the HELENA Trial

2016 ◽  
Vol 51 ◽  
pp. 28-33 ◽  
Author(s):  
Ruth Schübel ◽  
Mirja E. Graf ◽  
Johanna Nattenmüller ◽  
Diana Nabers ◽  
Disorn Sookthai ◽  
...  
2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 736-737
Author(s):  
Blanka Rogina

Abstract Aging is associated with a functional decline in metabolic, physiological, proliferative, and tissue homeostasis leading to deterioration at an organismal level and increases risk for disease and death. Genetic, pharmacological and nutritional interventions have been successfully used to preserve metabolic health, which leads to preserved healthspan and extended longevity. This symposium will discuss new approaches to nutrition and diet and mechanisms underlying interventions such as calorie restriction and genetic CR. We will also discuss species-specific metabolic mechanisms based on longitudinal studies in mice, monkeys and humans.


2019 ◽  
Vol 40 (2) ◽  
pp. 92-103 ◽  
Author(s):  
Janko Međedović ◽  
Goran Knežević

Abstract. Earlier research suggested that militant extremists could have certain aspects of psychopathic and psychotic characteristics. Relying on these studies, we investigated whether the Militant Extremist Mind-Set (MEM) could be explained by psychopathy, sadism, and Disintegration (psychosis proneness), as subclinical manifestations of amoral, antisocial, and psychotic-like traits. In Study 1 (306 undergraduate students), it was shown that sadistic and psychopathic tendencies were related to Proviolence (advocating violence as a means for achieving a goal); psychopathic and disintegrative tendencies were associated to the Vile World (belief in a world as a corrupted and vile place), while Disintegration was the best predictor of Divine Power (relying on supernatural forces as a rationale for extremist acts). In Study 2 (147 male convicts), these relations were largely replicated and broadened by including implicit emotional associations to violence in the study design. Thus, while Proviolence was found to be related to a weakened negative emotional reaction to violent pictures, Vile World was found to be associated with stronger negative emotions as a response to violence. Furthermore, Proviolence was the only MEM factor clearly differentiating the sample of convicts from male students who participated in Study 1. Results help extend current understanding about personal characteristics related to militant extremism.


2010 ◽  
Author(s):  
Cecile Lengacher ◽  
Michelle Barta ◽  
Pinky Budhrani ◽  
Melissa Shelton ◽  
Irina Carranza ◽  
...  

2005 ◽  
Vol 35 (4) ◽  
pp. 63
Author(s):  
NANCY WALSH
Keyword(s):  

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