The adhesion G protein-coupled receptor G2 (ADGRG2/GPR64) constitutively activates SRE and NFκB and is involved in cell adhesion and migration

2015 ◽  
Vol 27 (12) ◽  
pp. 2579-2588 ◽  
Author(s):  
Miriam C. Peeters ◽  
Michiel Fokkelman ◽  
Bob Boogaard ◽  
Kristoffer L. Egerod ◽  
Bob van de Water ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
G Protein ◽  
G Protein Coupled Receptor ◽  
Cell Adhesion And Migration ◽  
And Migration ◽  
G Protein Coupled

scholarly journals A PKA-Csk-pp60Src signaling pathway regulates the switch between endothelial cell invasion and cell-cell adhesion during vascular sprouting

Blood ◽  
2010 ◽  
Vol 116 (25) ◽  
pp. 5773-5783 ◽  
Author(s):  
Hui Jin ◽  
Barbara Garmy-Susini ◽  
Christie J. Avraamides ◽  
Konstantin Stoletov ◽  
Richard L. Klemke ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Endothelial Cell ◽  
G Protein ◽  
Receptor Activation ◽  
Cell Polarization ◽  
Endothelial Cell Migration ◽  
Cell Adhesion And Migration ◽  
And Migration ◽  
G Protein Coupled ◽  
Cell Cell

Abstract Angiogenesis is controlled by signals that stimulate motility in endothelial cells at the tips of vascular sprouts while maintaining cell-cell adhesion in the stalks of angiogenic sprouts. We show here that Gs-linked G protein–coupled receptor activation of cAMP-dependent protein kinase (PKA) plays an important role in regulating the switch between endothelial cell adhesion and migration by activating C-terminal Src kinase, leading to inhibition of pp60Src. Activated PKA blocks pp60Src-dependent vascular endot helial-cadherin phosphorylation, thereby stimulating cell-cell adhesion while suppressing endothelial cell polarization, motility, angiogenesis, and vascular permeability. Similar to the actions of Notch and Dll4, PKA activation blocks sprouting in newly forming embryonic blood vessels, while PKA inhibition promotes excessive sprouting in these vessels. These findings demonstrate that G protein–coupled receptors and PKA regulate vascular sprouting during angiogenesis by controlling endothelial cell migration and cell-cell adhesion through their actions on pp60Src.

scholarly journals The G Protein-Coupled Receptor Kinases (GRKs) in Chemokine Receptor-Mediated Immune Cell Migration: From Molecular Cues to Physiopathology

Cells ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 75
Author(s):  
Marta Laganà ◽  
Géraldine Schlecht-Louf ◽  
Françoise Bachelerie
Keyword(s):  
G Protein ◽  
Chemokine Receptor ◽  
Immune Cell ◽  
Neutrophil Migration ◽  
G Protein Coupled Receptor ◽  
Receptor Kinases ◽  
Immune Cell Migration ◽  
And Migration ◽  
G Protein Coupled ◽  
Gpcr Desensitization

Although G protein-coupled receptor kinases (GRKs) have long been known to regulate G protein-coupled receptor (GPCR) desensitization, their more recently characterized functions as scaffolds and signalling adapters underscore that this small family of proteins governs a larger array of physiological functions than originally suspected. This review explores how GRKs contribute to the complex signalling networks involved in the migration of immune cells along chemokine gradients sensed by cell surface GPCRs. We outline emerging evidence indicating that the coordinated docking of several GRKs on an active chemokine receptor determines a specific receptor phosphorylation barcode that will translate into distinct signalling and migration outcomes. The guidance cues for neutrophil migration are emphasized based on several alterations affecting GRKs or GPCRs reported to be involved in pathological conditions.

scholarly journals Adhesion G protein-coupled receptor VLGR1/ADGRV1 regulates cell spreading and migration by mechanosensing at focal adhesions

iScience ◽  
2021 ◽  
Vol 24 (4) ◽  
pp. 102283
Author(s):  
Deva K. Kusuluri ◽  
Baran E. Güler ◽  
Barbara Knapp ◽  
Nicola Horn ◽  
Karsten Boldt ◽  
...  
Keyword(s):  
G Protein ◽  
Focal Adhesions ◽  
Cell Spreading ◽  
G Protein Coupled Receptor ◽  
And Migration ◽  
G Protein Coupled

scholarly journals Orphan G protein-coupled receptor GPRC5A modulates integrin β1-mediated epithelial cell adhesion

2017 ◽  
Vol 11 (5-6) ◽  
pp. 434-446 ◽  
Author(s):  
Daria R. Bulanova ◽  
Yevhen A. Akimov ◽  
Anne Rokka ◽  
Teemu D. Laajala ◽  
Tero Aittokallio ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Epithelial Cell ◽  
G Protein ◽  
G Protein Coupled Receptor ◽  
Integrin Β1 ◽  
G Protein Coupled

scholarly journals Cell adhesion controlled by adhesion G protein–coupled receptor GPR124/ADGRA2 is mediated by a protein complex comprising intersectins and Elmo–Dock

2017 ◽  
Vol 292 (29) ◽  
pp. 12178-12191 ◽  
Author(s):  
Magda Nohemí Hernández-Vásquez ◽  
Sendi Rafael Adame-García ◽  
Noumeira Hamoud ◽  
Rony Chidiac ◽  
Guadalupe Reyes-Cruz ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
G Protein ◽  
Protein Complex ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled
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