Role of the endogenous obestatin/G-protein coupled receptor 39 (GPR39) system in the regulation of proliferation and migration of activated human pancreatic stellate cells

Pancreatology ◽  
2018 ◽  
Vol 18 (4) ◽  
pp. S118
Author(s):  
Lara Estévez-Perez ◽  
Saul Leal-lopez ◽  
Agustin Sanchez-Temprano ◽  
Begoña Otero-Alen ◽  
Carlos Seoane-Mosteiro ◽  
...  
Keyword(s):  
G Protein ◽  
Stellate Cells ◽  
Pancreatic Stellate Cells ◽  
G Protein Coupled Receptor ◽  
Regulation Of Proliferation ◽  
And Migration ◽  
G Protein Coupled ◽  
Proliferation And Migration

scholarly journals The G Protein-Coupled Receptor Kinases (GRKs) in Chemokine Receptor-Mediated Immune Cell Migration: From Molecular Cues to Physiopathology

Cells ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 75
Author(s):  
Marta Laganà ◽  
Géraldine Schlecht-Louf ◽  
Françoise Bachelerie
Keyword(s):  
G Protein ◽  
Chemokine Receptor ◽  
Immune Cell ◽  
Neutrophil Migration ◽  
G Protein Coupled Receptor ◽  
Receptor Kinases ◽  
Immune Cell Migration ◽  
And Migration ◽  
G Protein Coupled ◽  
Gpcr Desensitization

Although G protein-coupled receptor kinases (GRKs) have long been known to regulate G protein-coupled receptor (GPCR) desensitization, their more recently characterized functions as scaffolds and signalling adapters underscore that this small family of proteins governs a larger array of physiological functions than originally suspected. This review explores how GRKs contribute to the complex signalling networks involved in the migration of immune cells along chemokine gradients sensed by cell surface GPCRs. We outline emerging evidence indicating that the coordinated docking of several GRKs on an active chemokine receptor determines a specific receptor phosphorylation barcode that will translate into distinct signalling and migration outcomes. The guidance cues for neutrophil migration are emphasized based on several alterations affecting GRKs or GPCRs reported to be involved in pathological conditions.

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