The vasorelaxant effect and its mechanisms of sodium bisulfite as a sulfur dioxide donor

Chemosphere ◽  
2012 ◽  
Vol 89 (5) ◽  
pp. 579-584 ◽  
Author(s):  
Ziqiang Meng ◽  
Zhenhua Yang ◽  
Junling Li ◽  
Quanxi Zhang
2008 ◽  
Vol 29 (8) ◽  
pp. 923-930 ◽  
Author(s):  
Shu-xu DU ◽  
Hong-fang JIN ◽  
Ding-fang BU ◽  
Xia ZHAO ◽  
Bin GENG ◽  
...  

Author(s):  
В.О. ГОРОДЕЦКИЙ ◽  
С.О. СЕМЕНИХИН ◽  
Н.М. ДАИШЕВА ◽  
Н.И. КОТЛЯРЕВСКАЯ

Для увеличения производительности сахарного завода без существенных финансовых затрат можно использовать технологическую схему вывода сиропа на длительное хранение с последующей его переработкой в межсезонье. Одним из недостатков такой технологической схемы является риск микробиологической обсемененности сиропа, для снижения которой отечественные исследователи предлагают обработку электромагнитными полями. Однако, на наш взгляд, обработка сиропа сульфитсодержащими реагентами более безопасна и менее энергоемка. Проведены лабораторные исследования, направленные на снижение микробиологической обсемененности сиропа при выводе его на хранение. Объектом исследований был полученный в лабораторных условиях концентрированный сироп с содержанием сухих веществ 67%, который делили на три образца по 300 мл каждый. Контрольный образец сиропа оставляли без обработки, образец 1 обрабатывали сернистым ангидридом до рН 7,3–7,5, образец 2 – раствором бисульфита натрия в количестве 0,01% к массе образца. После этого все три образца подвергали подщелачиванию 1 н раствором NaOH до pH 9,15 и хранили в течение 100 сут при комнатной температуре. По окончанию срока хранения в образцах сиропа определяли микробиологические показатели и содержание редуцирующих веществ. Установлено, что предварительная обработка сиропа, направляемого на длительное хранение, сульфитсодержащими реагентами способствует достаточно эффективному снижению количества мезофильных аэробных и факультативно-анаэробных микроорганизмов и плесеней. Наибольший эффект снижения наблюдается при обработке сиропа сернистым ангидридом: на 69% снижается показатель микробиальной обсемененности и на 58% количество плесеней по сравнению с необработанным сиропом. При обработке сиропа бисульфитом натрия снижение составило 31 и 33% соответственно. Степень предотвращения накопления редуцирующих веществ при обработке сиропа сернистым ангидридом составила 18,8%, а при обработке бисульфитом натрия – 11,5%. Снижение микробиальной обсемененности сиропа при выводе его на длительное хранение будет способствовать снижению потерь сахарозы. To increase the productivity of the sugar factory without significant financial costs, you can use a technological scheme for the withdrawal of thick juice for long-term storage with its subsequent processing in the off-season. One of the disadvantages of such a technological scheme is the risk of microbiological contamination of the thick juice, to reduce which domestic researchers offer treatment with electromagnetic fields. However, in our opinion, the treatment of thick juice with sulfite-containing reagents is safer and less energy intensive. Laboratory studies aimed at reducing the microbiological contamination of the thick juiceduring its storage were carried out. The object of research was a concentrated thick juice obtained under laboratory conditions with a dry matter content of 67%, which was divided into three samples of 300 ml each. The control sample of the thick juice was left untreated, sample 1 was treated with sulfur dioxide to a pH of 7,3–7,5, sample 2 – with a solution of sodium bisulfite in an amount of 0.01% by weight of the sample. After that, all three samples were alkalized with 1 n NaOH solution to pH 9,15 and stored for 100 days at room temperature. At the end of the shelf life, microbiological parameters and the content of reducing substances were determined in the thick juice samples. It was found that the pretreatment of thick juice sent for long-term storage with sulfite-containing reagents contributes to a sufficiently effective reduction in the number of mesophilic aerobic and facultative anaerobic microorganisms and molds. The greatest reduction effect is observed when the thick juice is treated with sulfurous anhydride: the indicator of microbial contamination is reduced by 69% and the number of molds is reduced by 58% compared to untreated thick juice. When treating the syrup with sodium bisulfite, the reduction was 31 and 33% respectively. The degree of prevention of the accumulation of reducing substances when treating the thick juice with sulfur dioxide was 18,8%, and when treating with sodium bisulfite – 11,5%. Reducing the microbial contamination of the thick juicewhen it is taken out for long-term storage will help to reduce the loss of sucrose.


Author(s):  
L. A. Nikolaeva ◽  
◽  
E. M. Khusnutdinova ◽  

It is proposed to purify industrial gas emissions from sulfur dioxide by the adsorption method. Waste from the power industry - sludge from the chemical water treatment of Kazan CHPP-1 - was used as an adsorption material. Its chemical composition is presented. Experimental studies of a new sorption material based on energy waste for gas purification from sulfur dioxide have been carried out. The kinetic dependence and isotherm of the adsorption process are obtained. The mechanism of the process of adsorption of sulfur dioxide by sorption material at different temperatures has been studied. The Gibbs free energy, differential heat, and activation energy of adsorption are determined. The economic and environmental impact of modernization of procedure for cleaning gas emissions from sulfur dioxide in sodium bisulfite production at JSC “Chemical factory named after L.Ya. Karpov” was measured.


2020 ◽  
Vol 28 (4) ◽  
pp. 397-407
Author(s):  
Larisa A. Nikolaeva ◽  
Elvira M. Khusnutdinova

Chemical industry enterprises are the main environmental pollutants that cause environmental problems. This is due to the production technology and the toxicity of some substances. In this paper, it is proposed to purify the gas emissions at the JSC Karpov Chemical Plant formed during the production of sodium bisulfite from sulfur dioxide by the adsorption method. As a sorption material, a modified energy waste - carbonate sludge from the chemical water treatment plant of the Naberezhnye Chelny CHPP - was used. The technological characteristics of the granular sorption material are presented. A batch adsorber with a fixed layer of granular sorption material is calculated. The modernization of the technological scheme for cleaning gas emissions from sulfur dioxide of the production line of sodium bisulfite at JSC Chemical Plant named after L.Ya. Karpov is proposed. The calculation of the prevented environmental damage and the economic effect of the modernization of the technological scheme is made.


2015 ◽  
Vol 35 (4) ◽  
pp. 418-427 ◽  
Author(s):  
Q Zhang ◽  
Y Bai ◽  
Z Yang ◽  
J Tian ◽  
Z Meng

This study investigated the molecular mechanism of the effect of sulfur dioxide (SO2) on the expression of adenosine triphosphate (ATP)-sensitive potassium ion (K+; KATP) channel, big-conductance calcium ion (Ca2+)-activated K+ (BKCa) channel, and L-type (L-Ca2+) channel subunits in rat aortas with quantitative reverse transcription polymerase chain reaction (qRT-PCR) and Western blot. The results showed that the messenger RNA and protein levels of the KATP channel subunits Kir6.1, Kir6.2, and sulfonylurea receptor 2B (SUR2B) of rat aortas were significantly increased by SO2 at 14 mg/m3, whereas the levels of SUR2A were not changed. SO2 at all the treated concentrations markedly raised the expression of the BKCa channel subunits α and β1. SO2 at 14 mg/m3 significantly decreased the expression of the L-Ca2+ channel Cav1.2 and Cav1.3. The histological examination of rat aorta tissues showed moderate injury of tunica media in the presence of SO2 at 14 mg/m3. These suggest that SO2 can activate the KATP and BKCa channels by upregulating the expression of Kir6.1, Kir6.2, SUR2B, BKCa α, and BKCa β1, while inhibit the L-Ca2+ channels by downregulating the expression of Cav1.2 and Cav1.3 in rat aortas. The molecular mechanism of SO2-induced vasorelaxant effect might be linked to the changes in expression of these channel subunits, which plays an important role in the pathogenesis of SO2-associated cardiovascular diseases.


2019 ◽  
Author(s):  
Satish Malwal ◽  
Kundansinghsingh Pardeshi ◽  
Harinath Chakrapani

<div>Although sulfur dioxide (SO<sub>2</sub>) finds widespread use in the food industry as its hydrated form, sulfite, a number of aspects of SO<sub>2 </sub>biology remain to be completely understood. Among the tools available for intracellular enhancement of SO<sub>2</sub>, most suffer from poor cell permeability and a lack of control over SO<sub>2</sub> release. We report 1,2-cyclic sulfite diesters as a new class of reliable SO<sub>2 </sub>donors that dissociate in buffer through a nucleophilic displacement to produce SO<sub>2 </sub>with tuneable release profiles. We provide data in support of the suitability of these SO<sub>2 </sub>donors to enhance intracellular levels of SO<sub>2 </sub>at an efficiency superior to sodium bisulfite, the most commonly used SO<sub>2</sub> donor for cellular studies.</div>


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