Controlled drug release via minimization of burst release in pH-response kappa-carrageenan/polyvinyl alcohol hydrogels

The present paper aims to study the possibility to modify the properties of polyvinyl alcohol (pva) cryogels prepared in the presence of ketoprofen in order to replace the damaged articular cartilage. Articular cartilage is the most important part of articulation characterized by very low friction, high wear resistance, and poor regenerative qualities. Polyvinyl alcohol is a non-expensive polymer, versatile and adaptable to various needs, with exceptional properties such as water solubility, biocompatibility, non-toxicity and with capability to form hydrogels by chemical or physical methods. The aims of this paper are the synthesis, the physicochemical characterization and analysis of the tribological properties of pva cryogels for cartilage replacement and the introduction of new concept in medication by creating the cryogel like a controlled drug release system. The morphology of the cryogels, the interaction between the pva macromolecular chains and medicament has been studied by Scanning Electronic Microscopy. The gels swelling in physiologic ser have been monitored by gravimetric method in order to evidence the hydrophilic properties. The mechanical properties of the cryogels have been investigated by dynamic mechanical measurements. In conclusion, the biomaterial obtained provides good swelling properties, mechanical resistance and it is ideal for extended drug release implantable systems.

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Functionalized polyvinyl alcohol derivatives thin films for controlled drug release and targeting systems: MAPLE deposition and morphological, chemical and in vitro characterization

Applied Surface Science ◽

10.1016/j.apsusc.2008.09.047 ◽

2009 ◽

Vol 255 (10) ◽

pp. 5600-5604 ◽

Cited By ~ 19

Author(s):

R. Cristescu ◽

C. Popescu ◽

A.C. Popescu ◽

S. Grigorescu ◽

L. Duta ◽

...

Keyword(s):

Thin Films ◽

Drug Release ◽

Polyvinyl Alcohol ◽

Controlled Drug Release ◽

In Vitro Characterization

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Preparation of polyvinyl alcohol, chitosan and polyurethane-based pH-sensitive and biodegradable hydrogels for controlled drug release applications

International Journal of Polymeric Materials ◽

10.1080/00914037.2019.1670180 ◽

2019 ◽

Vol 69 (18) ◽

pp. 1167-1177 ◽

Cited By ~ 3

Author(s):

Umran Duru Kamacı ◽

Musa Kamacı

Keyword(s):

Drug Release ◽

Polyvinyl Alcohol ◽

Controlled Drug Release ◽

Ph Sensitive ◽

Biodegradable Hydrogels

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Bioactive Calcium Silicate Coating of Titania Nanotubes for Controlled Drug Release

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.1033-1034.1005 ◽

2014 ◽

Vol 1033-1034 ◽

pp. 1005-1008

Author(s):

Ping Li ◽

Zhang Wang ◽

Fei Luo ◽

Xiu Feng Xiao

Keyword(s):

Drug Release ◽

Calcium Silicate ◽

Controlled Drug Release ◽

Burst Release ◽

X Ray Diffraction ◽

Immersion Method ◽

Silicate Coating ◽

Titania Nanotube Arrays ◽

Ft Ir ◽

Electronic Microscope

A novel and facile process called “alternative loop immersion method” formed bioactive and biocompatible Zn-doped calcium silicate coating over the drug-loaded titania nanotube arrays to improve the properties of drug release. The samples were characterized by scanning electronic microscope (SEM), x-ray diffraction (XRD) and fourier transform infrared (FT-IR). The results show that TNTs modified by Zn-doped calcium silicate coating possess improved drug release characteristics with reduced burst release (from 83% to 66%) and prolonged drug release (from 11 days to over 15 days). This approach provides an alternative to tailor the surface of TNTs and offer considerable propects for diverse biomedical applications.

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Graphene reinforced radiation crosslinked polyvinyl alcohol/carboxymethyl cellulose nanocomposites for controlled drug release

Polymer Composites ◽

10.1002/pc.23823 ◽

2015 ◽

Vol 38 ◽

pp. E74-E80 ◽

Cited By ~ 1

Author(s):

Jhimli P. Guin ◽

C.V. Chaudhari ◽

K.A. Dubey ◽

Y.K. Bhardwaj ◽

L. Varshney

Keyword(s):

Drug Release ◽

Polyvinyl Alcohol ◽

Carboxymethyl Cellulose ◽

Controlled Drug Release ◽

Cellulose Nanocomposites

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Electrospun Fibre Composite for Controlled Drug Release

MRS Advances ◽

10.1557/adv.2020.268 ◽

2020 ◽

Vol 5 (46-47) ◽

pp. 2409-2417

Author(s):

Ryan Go ◽

Shadi Houshyar ◽

Kate Fox ◽

Yen Bach Truong

Keyword(s):

Drug Release ◽

Fibre Composite ◽

Extended Period ◽

Controlled Drug Release ◽

Burst Release ◽

The Core ◽

Potential System ◽

Shell Composition ◽

Severe Health Problem

AbstractA drug delivery system with sustainable controlled drug release can improve the quality of life of a patient by reducing the side-effects and better absorption of the drug locally. However, the main disadvantageous of this delivery model is the burst release of the drug, which can result in severe health problem, such as toxicity. Here in this study, a new coaxial microfiber has been developed with encapsulated anti-inflammatory drug, ibuprofen, inside the core structure of the coaxial fibre. The core consisting of polyethylene oxide (PEO) carrying the drug was covered with the polylactic acid (PLA)/PEO and shell to prevent the burst release of the drug and provide sustainable release over a prolonged time. The release profiles showed that the burst release was reduced from 20% in control scaffold, core only, to 5% in core-shell structure after 6 hrs. The higher percentage of PLA in the shell composition provides a slower release of ibuprofen, due to the slower degradation of PLA in comparison with PEO. The result indicates the developed structure can be a potential system for the localized release of the various drug system, which leads to a more sustainable and controlled release of the drug over the more extended period and deliver a better outcome along with side-effect prevention.

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Remote magnetically controlled drug release from electrospun composite nanofibers: design of a smart platform for therapy of psoriasis

Zeitschrift für Naturforschung A ◽

10.1515/zna-2020-0087 ◽

2020 ◽

Vol 75 (7) ◽

pp. 587-591

Author(s):

Natália Babincová ◽

Oldřich Jirsák ◽

Melánia Babincová ◽

Peter Babinec ◽

Mária Šimaljaková

Keyword(s):

Magnetic Field ◽

Magnetic Nanoparticles ◽

Drug Release ◽

Polyvinyl Alcohol ◽

Efficient Method ◽

Large Scale ◽

Composite Nanofibers ◽

Controlled Drug Release ◽

Stimuli Responsive ◽

Nano Fiber

AbstractAn efficient method for the large-scale fabrication of composite polyvinyl alcohol polymer nano fibers loaded with magnetic nanoparticles and methotrexate is reported in this study. We have demonstrated that nonwoven textile formed by needleless electro spinning is effective in immobilization and triggered the release of drugs, which is achieved by an alternating magnetic field induced heating of magnetic nanoparticles. This smart stimuli-responsive release ability, biocompatibility, and ultra-lightweight property render enormous potential for this electrospun nano fiber mat to be used as an anti-psoriatic drugs release platform, which may have far-reaching applications in dermatology.

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