Electrospun Fibre Composite for Controlled Drug Release

MRS Advances ◽  
2020 ◽  
Vol 5 (46-47) ◽  
pp. 2409-2417
Author(s):  
Ryan Go ◽  
Shadi Houshyar ◽  
Kate Fox ◽  
Yen Bach Truong
Keyword(s):  
Drug Release ◽  
Fibre Composite ◽  
Extended Period ◽  
Controlled Drug Release ◽  
Burst Release ◽  
The Core ◽  
Potential System ◽  
Shell Composition ◽  
Severe Health Problem

AbstractA drug delivery system with sustainable controlled drug release can improve the quality of life of a patient by reducing the side-effects and better absorption of the drug locally. However, the main disadvantageous of this delivery model is the burst release of the drug, which can result in severe health problem, such as toxicity. Here in this study, a new coaxial microfiber has been developed with encapsulated anti-inflammatory drug, ibuprofen, inside the core structure of the coaxial fibre. The core consisting of polyethylene oxide (PEO) carrying the drug was covered with the polylactic acid (PLA)/PEO and shell to prevent the burst release of the drug and provide sustainable release over a prolonged time. The release profiles showed that the burst release was reduced from 20% in control scaffold, core only, to 5% in core-shell structure after 6 hrs. The higher percentage of PLA in the shell composition provides a slower release of ibuprofen, due to the slower degradation of PLA in comparison with PEO. The result indicates the developed structure can be a potential system for the localized release of the various drug system, which leads to a more sustainable and controlled release of the drug over the more extended period and deliver a better outcome along with side-effect prevention.

PREPARATION, EVALUATION AND OPTIMIZATION OF MUCOADHESIVE MINI TABLETS OF TELMISARTAN BY USING SINGLE UNIT ENCAPSULATION SYSTEM

INDIAN DRUGS ◽  
2019 ◽  
pp. 64-67
Author(s):  
Indrajeet S. Patil ◽  
Omkar A. Patil ◽  
Rohankumar R. Chavan ◽  
Dheeraj S. Randive ◽  
Mangesh A. Bhutkar ◽  
...  
Keyword(s):  
Drug Release ◽  
Single Unit ◽  
Chemical Interaction ◽  
Extended Period ◽  
Controlled Drug Release ◽  
Wet Granulation ◽  
Dissolution Study ◽  
Capsule Shell ◽  
Physical And Chemical

The objective of the present study was to develop and optimize capsule filled oral mucoadhesive minitablets of telmisartan. Wet granulation method was employed for the development of minitablets. All the formulations (F1- F13) exhibited more than 21% drug release at 4h and at the end of 12h it showed drug release more than 90%. During the dissolution study it was observed that the capsule shell in which the minitablets were filled got completely dissolved in the first 5 min. FTIR and UV study showed absence of any significant physical and chemical interaction between drug and polymers. Formulation F 10 was found to possess higher drug release at 4h and 12 h. Combination of HPMC and Carbopol was found to be suitable for formulation of mucoadhesive minitablets, showed promising mucoadhesive strength and exhibited controlled drug release over an extended period of time.

PREPARATION, EVALUATION AND OPTIMIZATION OF MUCOADHESIVE MINI TABLETS OF TELMISARTAN BY USING SINGLE UNIT ENCAPSULATION SYSTEM

INDIAN DRUGS ◽  
2019 ◽  
Vol 56 (05) ◽  
pp. 64-67
Author(s):  
I. S. Patil ◽  
◽  
O. A. Patil ◽  
R. R Chavan ◽  
D. S. Randive ◽  
...  
Keyword(s):  
Drug Release ◽  
Single Unit ◽  
Chemical Interaction ◽  
Extended Period ◽  
Controlled Drug Release ◽  
Wet Granulation ◽  
Dissolution Study ◽  
Capsule Shell ◽  
Physical And Chemical

The objective of the present study was to develop and optimize capsule filled oral mucoadhesive minitablets of telmisartan. Wet granulation method was employed for the development of minitablets. All the formulations (F1- F13) exhibited more than 21% drug release at 4h and at the end of 12h it showed drug release more than 90%. During the dissolution study it was observed that the capsule shell in which the minitablets were filled got completely dissolved in the first 5 min. FTIR and UV study showed absence of any significant physical and chemical interaction between drug and polymers. Formulation F 10 was found to possess higher drug release at 4h and 12 h. Combination of HPMC and Carbopol was found to be suitable for formulation of mucoadhesive minitablets, showed promising mucoadhesive strength and exhibited controlled drug release over an extended period of time.

Bioactive Calcium Silicate Coating of Titania Nanotubes for Controlled Drug Release

2014 ◽  
Vol 1033-1034 ◽  
pp. 1005-1008
Author(s):  
Ping Li ◽  
Zhang Wang ◽  
Fei Luo ◽  
Xiu Feng Xiao
Keyword(s):  
Drug Release ◽  
Calcium Silicate ◽  
Controlled Drug Release ◽  
Burst Release ◽  
X Ray Diffraction ◽  
Immersion Method ◽  
Silicate Coating ◽  
Titania Nanotube Arrays ◽  
Ft Ir ◽  
Electronic Microscope

A novel and facile process called “alternative loop immersion method” formed bioactive and biocompatible Zn-doped calcium silicate coating over the drug-loaded titania nanotube arrays to improve the properties of drug release. The samples were characterized by scanning electronic microscope (SEM), x-ray diffraction (XRD) and fourier transform infrared (FT-IR). The results show that TNTs modified by Zn-doped calcium silicate coating possess improved drug release characteristics with reduced burst release (from 83% to 66%) and prolonged drug release (from 11 days to over 15 days). This approach provides an alternative to tailor the surface of TNTs and offer considerable propects for diverse biomedical applications.

Near-infrared light-controlled drug release and cancer therapy with polymer-caged upconversion nanoparticles

RSC Advances ◽  
2015 ◽  
Vol 5 (7) ◽  
pp. 5269-5276 ◽  
Author(s):  
Qingjian Xing ◽  
Najun Li ◽  
Yang Jiao ◽  
Dongyun Chen ◽  
Jiaying Xu ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Drug Release ◽  
Self Assembly ◽  
Near Infrared ◽  
Controlled Drug Release ◽  
Infrared Light ◽  
Upconversion Nanoparticles ◽  
Assembly Process ◽  
The Core ◽  
Triggered Drug Release

The core–shell nanocarrier, based on spiropyran-containing copolymer coated upconversion nanocomposites, was successfully prepared via a facile self-assembly process for NIR-triggered drug release and cancer therapy.

Photo-cross-linked poly(ether amine) micelles for controlled drug release

RSC Advances ◽  
2015 ◽  
Vol 5 (128) ◽  
pp. 105880-105888 ◽  
Author(s):  
Haozhe He ◽  
Yanrong Ren ◽  
Yuge Dou ◽  
Tao Ding ◽  
Xiaomin Fang ◽  
...  
Keyword(s):  
Drug Release ◽  
Controlled Drug Release ◽  
Burst Release ◽  
The Stability

In order to improve the stability of micelles and decrease the burst release of loaded drugs, photo-cross-linked micelles were prepared via photodimerization of the coumarin moiety on amphiphilic poly(ether amine) (PEAC).

Assessment of multimorbidity of diseases in geriatric practice

2020 ◽  
pp. 17-21
Author(s):  
Mark Oprenko
Keyword(s):  
Quality Of Life ◽  
The Core ◽  
Definition Of

The definition of the multimorbidity concept reveals insufficient specificity of the comorbidity and multimorbidity definitions and, as a result, confusion in the use of these terms. Most authors are unanimous that the “core” of multimorbidity is presence of more than one disease in a patient. These coexisting diseases can be pathogenetically interconnected and non-interconnected. Regardless, the degree of multimorbidity always affects prognosis and quality of life.

STUDI ANALISIS DAMPAK PADEMI COVID-19 TERHADAP EKSISTENSI PEMBELAJARAN PENDIDIKAN AGAMA ISLAM DI INDONESIA

Edupedia ◽  
2020 ◽  
Vol 5 (1) ◽  
pp. 45-53
Author(s):  
Ilzam Dhaifi
Keyword(s):  
Online Education ◽  
Religious Education ◽  
Virtual Classroom ◽  
Education Services ◽  
Religious Consciousness ◽  
The Core ◽  
Equal Education ◽  
The World ◽  
The Government

The world has been surprised by the emergence of a COVID 19 pandemic, was born in China, and widespread to various countries in the world. In Indonesia, the government issued several policies to break the COVID 19 pandemic chain, which also triggered some pro-cons in the midst of society. One of the policies government takes is the closure of learning access directly at school and moving the learning process from physical class to a virtual classroom or known as online learning. In the economic sector also affects the parents’ financial ability to provide sufficient funds to support the implementation of distance learning applied by the government. The implications of the distance education policy are of course the quality of learning, including the subjects of Islamic religious education, which is essentially aimed at planting knowledge, skills, and religious consciousness to form the character of the students. Online education must certainly be precise, in order to provide equal education services to all students, prepare teachers to master the technology, and seek the core learning of Islamic religious education can still be done well.

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