Development of a multi-class method for the quantification of veterinary drug residues in feedingstuffs by liquid chromatography-tandem mass spectrometry

2010 ◽  
Vol 1217 (41) ◽  
pp. 6394-6404 ◽  
Author(s):  
Aurore Boscher ◽  
Cédric Guignard ◽  
Terence Pellet ◽  
Lucien Hoffmann ◽  
Torsten Bohn
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Tandem Mass Spectrometry ◽  
Veterinary Drug ◽  
Tandem Mass ◽  
Veterinary Drug Residues ◽  
Drug Residues ◽  
Chromatography Tandem Mass Spectrometry ◽  
Liquid Chromatography Tandem Mass

Development and Validation of a Multiclass Method for the Analysis of Veterinary Drug Residues in Eggs Using Liquid Chromatography-Tandem Mass Spectrometry

2016 ◽  
Vol 10 (4) ◽  
pp. 1063-1077 ◽  
Author(s):  
Flávia Lada Degaut Pontes ◽  
João Cleverson Gasparetto ◽  
Thais Martins Guimarães de Francisco ◽  
Heloise Calzado Goetzke ◽  
Letícia Paula Leonart ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Tandem Mass Spectrometry ◽  
Veterinary Drug ◽  
Tandem Mass ◽  
Veterinary Drug Residues ◽  
Drug Residues ◽  
Chromatography Tandem Mass Spectrometry ◽  
Liquid Chromatography Tandem Mass ◽  
Development And Validation

scholarly journals Simultaneous determination of multi-class veterinary drugs in fishery products with liquid chromatography–tandem mass spectrometry

2021 ◽  
Vol 64 (1) ◽  
Author(s):  
Eunjung Kim ◽  
Hyunjin Park ◽  
Sihyun Park ◽  
Jangduck Choi ◽  
Hae Jung Yoon ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Tandem Mass Spectrometry ◽  
Veterinary Drugs ◽  
Veterinary Drug ◽  
Tandem Mass ◽  
Drug Residues ◽  
Chromatography Tandem Mass Spectrometry ◽  
Liquid Chromatography Tandem Mass ◽  
Fishery Products

AbstractThe objective of this study was to optimize the analytical method for multi-class veterinary drug residues of 64 compounds in fishery products. Several compounds from veterinary drugs are banned or unauthorized in fishery products according to the Korean Food Code. Samples were extracted using acetonitrile/water (4:1, v/v) and the clean-up step was carried out by adding octadecylsilane and acetonitrile-saturated hexane. The target compounds were confirmed and quantified using liquid chromatography–tandem mass spectrometry (LC–MS/MS). The proposed method was validated according to the CODEX guidelines (CAC/GL-71), and most target compounds were found to be in acceptable quantities under the requirements of the validation guidelines. The recovery of analytes was typically in the 60–120% range, and precision, expressed as the coefficient of variation was less than 31% at all levels of concentration. The limit of quantification ranged from 0.03 to 3 μg kg−1 in the fishery products. Moreover, the application of the proposed method to 96 real samples demonstrated that no drug residues exceeded the Korean maximum residue limits (MRLs). This evaluation method provides reliable identification and quantification of multi-class veterinary drugs in fishery products and can be an efficient means to inspect drugs currently banned or not approved for aquaculture in Korea.

Comparison of different sample preparation procedures for multiclass determination of selected veterinary drug, coccidiostat and insecticide residues in eggs by liquid chromatography-tandem mass spectrometry

2014 ◽  
Vol 6 (9) ◽  
pp. 3034-3044 ◽  
Author(s):  
Marta Piatkowska ◽  
Piotr Jedziniak ◽  
Jan Zmudzki
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Sample Preparation ◽  
Tandem Mass Spectrometry ◽  
Veterinary Drug ◽  
Tandem Mass ◽  
Insecticide Residues ◽  
Chromatography Tandem Mass Spectrometry ◽  
Liquid Chromatography Tandem Mass

QuEChERS and zirconium-coated silica SPE in a multiresidue method for the analysis of veterinary drug residues and other contaminates in eggs by LC-MS/MS.

scholarly journals Quantitative Determination of Quinocetone and Its Metabolites in Chicken Plasma by Liquid Chromatography/Tandem Mass Spectrometry

2008 ◽  
Vol 91 (6) ◽  
pp. 1494-1498 ◽  
Author(s):  
Yong Li ◽  
Zhi Xian Gao ◽  
FangTing Dong ◽  
Yi Yong Cheng
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Tandem Mass Spectrometry ◽  
Multiple Reaction Monitoring ◽  
Veterinary Drug ◽  
Pharmacokinetic Studies ◽  
Tandem Mass ◽  
Chromatography Tandem Mass Spectrometry ◽  
Liquid Chromatography Tandem Mass

Abstract A new method has been established for the simultaneous determination of the new veterinary drug quinocetone (3-methyl-2-cinnamoyl-N-1,4-dioxyquioxaline; QTN) and its 2 metabolites de-monoxy-quinocetone (3-methyl-2-cinnamoyl-N-1-monoxyquinoxaline; DMO-QTN) and de-dioxyquinocetone (3-methyl-2-cinnamoyl-N-quinoxaline; DDI-QTN) in chicken plasma by liquid chromatography/tandem mass spectrometry (LC/MS/MS). The detection was performed using electrospray ionization in multiple reaction monitoring mode. The analysis of the linearity, accuracy, and precision of the method is described. The limits of detection and quantification of the LC/MS/MS method used for testing QTN, DMO-QTN, and DDI-QTN were 0.002 and 0.008 g/mL; 0.002 and 0.008 g/mL; and 0.003 and 0.010 g/mL, respectively. The method was validated and can be used in future pharmacokinetic studies.

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