METHYLGLYOXAL-DERIVED ADVANCED GLYCATION END-PRODUCTS PRODUCED AFTER MYOCARDIAL INFARCTION CONTRIBUTE TO NEGATIVE CARDIAC REMODELLING

2015 ◽  
Vol 31 (10) ◽  
pp. S149 ◽  
Author(s):  
N.J. Blackburn ◽  
B. Vulesevic ◽  
B. McNeill ◽  
A. Ostojic ◽  
A. Ahmadi ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Advanced Glycation End Products ◽  
Cardiac Remodelling ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
End Products

scholarly journals Characterization of advanced glycation end products and their receptor (RAGE) in an animal model of myocardial infarction

PLoS ONE ◽  
2019 ◽  
Vol 14 (1) ◽  
pp. e0209964 ◽  
Author(s):  
Bianca de Moraes Fracasso ◽  
Juliana Oliveira Rangel ◽  
Alessandra Gonçalves Machado ◽  
Fernanda Severo Curuja ◽  
Amanda Lopes ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Animal Model ◽  
Advanced Glycation End Products ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
End Products

scholarly journals CUPRAC-reactive Advanced Glycation End Products as Prognostic Markers of Human Acute Myocardial Infarction

Antioxidants ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 434
Author(s):  
Govigerel Bayarsaikhan ◽  
Delger Bayarsaikhan ◽  
Pyung Chun Oh ◽  
Woong Chol Kang ◽  
Bonghee Lee
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Correlation Analysis ◽  
Advanced Glycation End Products ◽  
Total Serum ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
End Products ◽  
Concentration Changes ◽  
Spearman’S Correlation

Cardiovascular disorders, especially acute coronary syndromes, are among the leading causes of mortality worldwide, and advanced glycation end products (AGEs) are associated with cardiovascular disease and serve as biomarkers for diagnosis and prediction. In this study, we investigated the utility of AGEs as prognostic biomarkers for acute myocardial infarction (AMI). We measured AGEs in serum samples of AMI patients (N = 27) using the cupric ion reducing antioxidant capacity (CUPRAC) method on days 0, 2, 14, 30, and 90 after AMI, and the correlation of serum AGE concentration and post-AMI duration was determined using Spearman’s correlation analysis. Compared to total serum protein, the level of CUPRAC reactive AGEs was increased from 0.9 to 2.1 times between 0–90 days after AMI incident. Furthermore, the glycation pattern and Spearman’s correlation analysis revealed four dominant patterns of AGE concentration changes in AMI patients: stable AGE levels (straight line with no peak), continuous increase, single peak pattern, and multimodal pattern (two or more peaks). In conclusion, CUPRAC-reactive AGEs can be developed as a potential prognostic biomarker for AMI through long-term clinical studies.

Activation of RAGE- dependent endoplasmic reticulum stress associates with exacerbated post- myocardial infarction ventricular arrhythmias in diabetes

2021 ◽  
Author(s):  
Zhongwei Liu ◽  
Yong Zhang ◽  
Shuo Pan ◽  
Chuan Qiu ◽  
Hao Jia ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Endoplasmic Reticulum ◽  
Enzymatic Activity ◽  
Advanced Glycation End Products ◽  
Ventricular Arrhythmias ◽  
Post Myocardial Infarction ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
End Products ◽  
Ryr2 Channel

Association between receptor for advanced glycation end products (RAGE) and post- myocardial infarction (MI) ventricular arrhythmias (VAs) in diabetes was investigated. Correlation between premature ventricular contractions (PVCs) and serum advanced glycation end products (AGEs) content was analyzed in a cohort consisted of 101 ST segment elevated MI (STEMI) patients. MI diabetic rats were treated with anti- receptor for AGE (RAGE) antibody. Electrocardiography was used to record VAs. Myocytes were isolated from adjacent area around infracted region. Immunofluorescent stains were used to evaluate association between FKBP12.6 (FK506-bindingprotein 12.6) and ryanodine receptor 2 (RyR2). Calcium sparks were evaluated by confocal microscope. Protein expression and phosphorylation were assessed by Western blotting. Calcineurin (CaN) enzymatic activity and RyR2 channel activity were also determined. In the cohort study, significantly increased amount of (PVCs) were found in STEMI patients with diabetes (P<0.05). Serum AGEs concentration was significantly positively correlated with PVCs amount in STEMI patients (r=0.416, P<0.001). Multivariate analysis showed serum AGEs concentration was independently and positively related to frequent PVCs (adjusted hazard ratio, 1.86; 95% CI, 1.09-3.18, P=0.022). In the animal study, increased glucose regulated protein 78 (GRP78) expression, protein kinase RNA-like ER kinase (PERK) phosphorylation, CaN enzymatic activity, FKBP12.6-RyR2 disassociation, RyR2 channel opening and endoplasmic reticulum (ER) calcium releasing were found in diabetic MI animals, which were attenuated by anti-RAGE antibody treatment. This RAGE blocking also significantly lowered the VAs amount in diabetic MI animals. Activation of RAGE- dependent ER stress- mediated PERK/CaN/RyR2 signaling participated in post-MI VAs in diabetes.

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