Evaluation of Gleason Grade Group 5 in a Contemporary Prostate Cancer Grading System and Literature Review

2020 ◽  
Author(s):  
Rei Kamitani ◽  
Kazuhiro Matsumoto ◽  
Takeo Kosaka ◽  
Toshikazu Takeda ◽  
Akinori Hashiguchi ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Literature Review ◽  
Grading System ◽  
Gleason Grade ◽  
Grade Group ◽  
Group 5 ◽  
Cancer Grading

Transcriptomic Heterogeneity of Gleason Grade Group 5 Prostate Cancer

2020 ◽  
Vol 78 (3) ◽  
pp. 327-332 ◽  
Author(s):  
Amar U. Kishan ◽  
Tahmineh Romero ◽  
Mohammed Alshalalfa ◽  
Yang Liu ◽  
Phuoc T. Tran ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Gleason Grade ◽  
Grade Group ◽  
Group 5

scholarly journals High SPOCK1 Expression is Associated with Advanced Stage, T Value, and Gleason Grade in Prostate Cancer

Medicina ◽  
2019 ◽  
Vol 55 (7) ◽  
pp. 343
Author(s):  
Chen ◽  
Ho ◽  
Yeh ◽  
Chen ◽  
Sung ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Clinicopathological Features ◽  
Gleason Grade ◽  
Advanced Stage ◽  
Grade Group ◽  
Clinical Role ◽  
Kaplan Meier ◽  
Advanced Tumor ◽  
Cox Proportional Hazard Models ◽  
Group 5

Prostate cancer (PCa) is a common malignancy in males and has a relatively slower progression than other cancers. Our goal was to evaluate the clinical role of SPARC (secreted protein acidic and cysteine rich, osteonectin), cwcv, and kazal-like domains’ proteoglycan 1 (SPOCK1) in PCa. SPOCK1 expression was studied through the immunohistochemical staining of specimens from 71 patients with PCa. The correlation between SPOCK1 expression and clinicopathological features was quantitatively analyzed. We used Kaplan–Meier analysis and Cox proportional hazard models to analyze the prognostic value. Of 71 PCa patients, high SPOCK1 expression was more likely to be seen in those with an advanced stage (p = 0.018) of the disease and an advanced tumor (T) value (p = 0.014). Patients in Gleason grade groups 3 and 4 had significantly higher SPOCK1 expression (p = 0.044 and 0.003, respectively) compared to those of Gleason grade group 1. However, this trend was not observed in patients in Gleason grade group 5. For the survival analysis, although it was not statistically significant, patients with a high SPOCK1 expression had a shorter median overall survival (6.2 years) compared to those with low expression (7.8 years). High SPOCK1 expression may be related to advanced clinicopathological features and possibly a poor prognosis. Further analysis with a larger patient base would help clarify this issue.

Contemporary International Society for Urological Pathology Grade Group System 2014: A 2-Year Retrospective Review of Prostate Cancers Diagnosed in Lagos University Teaching Hospital

2019 ◽  
Vol 152 (Supplement_1) ◽  
pp. S65-S66
Author(s):  
Lateef Odukoya ◽  
Luqman Adebayo ◽  
Charles Anunobi
Keyword(s):  
Prostate Cancer ◽  
Teaching Hospital ◽  
International Society ◽  
Prognostic Indicator ◽  
University Teaching ◽  
Grading System ◽  
Grade Group ◽  
Group System ◽  
Group 5 ◽  
Prostate Cancers

Abstract Introduction Prostate cancer is the second most frequent cancer worldwide. It is the commonest cancer among men in Nigeria. Gleason grading and scoring system constitute the most useful prognostic indicator in prostate cancer diagnosis and management. Over the years, it has gone through important modifications. The most recent of these changes was in 2014 by the International Society for Urological Pathology (ISUP). The WHO adopted the new grading system in 2016. It was not adopted as part of routine reporting of prostate cancer biopsies in Lagos University Teaching Hospital (LUTH) until 2017. The aim of this study is to categorize prostate cancers diagnosed in LUTH based on the grade group system and determine the pattern of prognostic distribution of prostate cancer cases since its adoption. Methods This is a descriptive study; data were retrieved from the histopathologic records of the Department of Anatomic Pathology. Prostate cancers cases diagnosed between 2017 and 2018 were stratified using the WHO-adopted 2014 ISUP grading system. Results During the 2 years, 93 cases of prostate cancers were diagnosed by core needle biopsies. Overall, mean age of cases was 69.85 years (SD 8.49, median = 70 years). Nearly 39% of the 93 cases were ISUP grade group 5 and about 24% were ISUP grade group 4. Together ISUP grade groups 3, 4, and 5 constituted 76.35% of all cases of prostate cancers. There was no statistically significant association between ISUP grade group and age (P = .266). Perineural invasion was present in 35.82% of cases. Sixty-seven percent of these were ISUP grade group 5. Conclusion The data from this study suggest that high-grade cancers, particularly those of the ISUP grade group 5, are the most frequently diagnosed prostate cancers in our institution. Further studies are required to document biochemical recurrence-free progression and survival among our patients.

scholarly journals Pelvic nodal radiotherapy in Gleason grade group 5 prostate cancer

2020 ◽  
Vol 9 (5) ◽  
pp. 2326-2328
Author(s):  
Kiri Cook ◽  
Amar U. Kishan
Keyword(s):  
Prostate Cancer ◽  
Gleason Grade ◽  
Grade Group ◽  
Group 5

scholarly journals New perspectives in modified Gleason’s grading for prostatic cancer and its comparison with original Gleason’s

2019 ◽  
Vol 7 (2) ◽  
pp. 400
Author(s):  
Sajjan Gupta ◽  
Ishan Dubey ◽  
Vandana Agarwal ◽  
Shalakha Agarwal
Keyword(s):  
Prostate Cancer ◽  
Gleason Score ◽  
Prognostic Significance ◽  
Clinical History ◽  
Grading System ◽  
Gleason Grade ◽  
Grade Group ◽  
Group I ◽  
Grade Groups ◽  
Study Laboratory

Background: The Gleason score is the most widely accepted histopathological grading system for prostate cancer since decade despite having many deficiency that can potentially impact patient health care. So ISUP agreed on developing a system of prognostic grade groups from I-V. Aim and objective was to study the new perspectives of modified Gleason’s grading and to compare it with original Gleason’s System with focus on the prognostic significance of the modifications.Methods: A retrospective study of 60 patients, who underwent TURP and Sextant biopsy and diagnosed as prostatic carcinoma in our institute were included in this study. Laboratory requisition forms with clinical history, PSA levels and histopathology reports of these patients were reviewed and graded accordingly to the newer gleasons. New Gleason grade includes five distinct Grade Groups based on the modified Gleason score groups. Grade Group 1 = Gleason score ≤6, Grade Group 2 = Gleason score 3 + 4 = 7, Grade Group 3 = Gleason score 4 + 3 = 7, Grade Group 4 = Gleason score 8, Grade Group 5 = Gleason scores 9 and 10 were assigned. The change in the grading system is tabulated and compared separately.Results: Patients age ranged from 55-80 years. The number of cases were 3,12,15,19 and 11 categorized under grade group I, grade group II, grade group III, grade group IV, grade group V cancer respectively according to modified gleason grading.Conclusions: Modified Gleason is a simplified grading system which may reduce over treatment of indolent prostate cancer. New gleasons grading clarifies the clinicians about the dilemma of gleason scores, offering an excellent prognostic stratification of this carcinoma.

scholarly journals KORELASI ANTARA EKSPRESI Her-2 DAN Ki-67 DENGAN GLEASON GRADE GROUP PADA ADENOKARSINOMA ASINAR PROSTAT

2019 ◽  
Vol 5 (1) ◽  
pp. 39-52
Author(s):  
Putri Ajeng ayu Larasati
Keyword(s):  
Tumor Suppressor Genes ◽  
Grading System ◽  
Gleason Grade ◽  
Grade Group ◽  
Ki 67 ◽  
Cross Sectional ◽  
Gleason Grading ◽  
Her 2 ◽  
Group 5 ◽  
Group 1

Latar Belakang : Menurut Database GLOBOCAN 2012, kanker prostat merupakan penyebab utama kelima kematian pada pria.(1) Pemahaman tentang peran onkogen dan tumor suppressor genes mendominasi penelitian tentang biologi kanker saat ini dan berpotensi menghasilkan target terapi kanker terbaru. Salah satu perannya pada adenokarsinoma prostat yang masih belum jelas ialah Her-2 dan Ki-67. Perbedaan ekspresi profil molekular Her-2 dan Ki-67 yang diklasifikasikan berdasarkan Gleason grading system terbaru yaitu Grade group diharapkan membantu penentuan prognosis dan manajemen terapi penyakit pada kanker prostat.Tujuan : Tujuan dari penelitian ini adalah untuk mengetahui korelasi antara ekspresi Her-2 dan Ki-67 dengan Gleason Grade group adenokarsinoma asinar prostat.Metode: Merupakan penelitian observatif analitik dengan desain cross-sectional menggunakan 31 blok parafin yang terfiksasi formalin dari laboratorium Patologi Anatomik RSUP dr. Kariadi, dengan diagnosis adenokarsinoma asinar prostat kemudian diklasifikasikan menurut kelompok prognostik WHO / ISUP Gleason (Gleason Grade group 1 - 5). Pemeriksaan imunohistokimia dilakukan dengan menggunakan antibodi Her-2 dan Ki-67. Analisa hasil menggunakan uji Spearmans dan uji Kruskal WallisHasil : 31 kasus yang termasuk dalam kriteria inklusi pada penelitian ini, hampir separuhnya (41.94%) termasuk ke dalam Gleason grade group 5. Ekspresi Her-2 positif (+1, +2, +3) hampir didapatkan pada seluruh sampel (90,22%), dengan Her-2 +3 sebagian besar didapatkan pada grade group 5 (71,43%). Ekspresi Ki-67 positif (+1, +2, +3) didapatkan pada seluruh sampel, dengan Ki-67 +3 (>5%) pada Gleason grade group 5 didapatkan sejumlah 5 sampel (38,46%). Pada analisa data dengan uji Spearmans disimpulkan bahwa terdapat korelasi positif antara ekspresi Her-2 dan Ki-67 dengan Gleason Grade group. Pada uji Kruskal Wallis didapatkan perbedaan bermakna antara ekspresi Ki-67 dengan Gleason Grade group.Kesimpulan: Analisa ekspresi Her-2 dan Ki-67 melalui pemeriksaan imunohistokimia dengan klasifikasi terbaru Gleason Grade group dapat menjadi salah satu parameter prognosis dan manajemen terapi pada adenokarsinoma asinar prostat.Kata kunci : Adenokarsinoma asinar prostat, Her-2, Ki-67, Gleason Grade group

scholarly journals Prostate-only Versus Whole-pelvis Radiation with or Without a Brachytherapy Boost for Gleason Grade Group 5 Prostate Cancer: A Retrospective Analysis

2020 ◽  
Vol 77 (1) ◽  
pp. 3-10 ◽  
Author(s):  
Kiri A. Sandler ◽  
Ryan R. Cook ◽  
Jay P. Ciezki ◽  
Ashley E. Ross ◽  
Mark M. Pomerantz ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Retrospective Analysis ◽  
Gleason Grade ◽  
Grade Group ◽  
Brachytherapy Boost ◽  
Group 5

scholarly journals Prostate cancer grading in 2018: limitations, implementations, cribriform morphology, and biological markers

2018 ◽  
Vol 33 (4) ◽  
pp. 331-334 ◽  
Author(s):  
Rodolfo Montironi ◽  
Alessia Cimadamore ◽  
Liang Cheng ◽  
Antonio Lopez-Beltran ◽  
Marina Scarpelli
Keyword(s):  
Prostate Cancer ◽  
Point Of View ◽  
The Other ◽  
Grading System ◽  
Grade Group ◽  
Gleason Grading ◽  
Gleason Pattern ◽  
Consensus Conferences ◽  
And Biological Markers ◽  
Cancer Grading

The Gleason grading system is among the most important prognostic factors in patients with prostate cancer. From the 2005 to the 2014 consensus conferences, organized by the International Society of Urological Pathology, the morphologic criteria for the identification of the Gleason patterns were redefined, thus resulting in the shrinkage of the Gleason pattern 3. This led to the expansion of the Gleason pattern 4. The newly proposed grade group system reduces the Gleason scores of prostate cancer to the lowest number, each associated with a unique behavior from the prognostic point of view. The advantage is that the simplified system with five groups allows for a more accurate stratification of the patients in comparison with the Gleason system. Cribriform, fused, ill-defined and glomeruloid glands are part of the histologic spectrum of the Gleason pattern 4. Cribriform morphology has a prognosis that is worse in comparison with the other non-cribriform Gleason 4 patterns. One of the major implications of the cribriform growth is that it precludes a patient from choosing active surveillance.

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