β-Trace protein — A marker of kidney function in children: “Original research communication–clinical investigation”

2007 ◽  
Vol 40 (13-14) ◽  
pp. 969-975 ◽  
Author(s):  
Arend Bökenkamp ◽  
Ingo Franke ◽  
Michael Schlieber ◽  
Gesche Düker ◽  
Joachim Schmitt ◽  
...  
Keyword(s):  
Kidney Function ◽  
Clinical Investigation ◽  
Protein A ◽  
Original Research ◽  
Research Communication

A simple and rapid HPLC method for the detection of glyburide in plasma original research communication (analytical)

2008 ◽  
Vol 41 (3) ◽  
pp. 167-173 ◽  
Author(s):  
Christelle Gedeon ◽  
Bhushan Kapur ◽  
Katarina Aleksa ◽  
Gideon Koren
Keyword(s):  
Hplc Method ◽  
Original Research ◽  
Research Communication

Role and advantage of cystatin C in kidney function monitoring during retroviral therapy

2017 ◽  
Vol 53 (1) ◽  
pp. 33-40
Author(s):  
Maria Warwas ◽  
Katarzyna Juszczyńska ◽  
Ewa Mulewicz ◽  
Jakub Gburek
Keyword(s):  
Kidney Function ◽  
Cystatin C ◽  
Clinical Investigation ◽  
Inhibitory Effect ◽  
Antiretroviral Drugs ◽  
Hiv Protease ◽  
Hiv Virus ◽  
Infection And Inflammation ◽  
Virus Strains

The aim of the study is to evaluate the utility of cystatin C (Cys C) determination in monitoring of HIV seropositive patients, based on recent literature concerning clinical investigation. Determination of serum CysC concentration can be helpful in monitoring the kidney function and eGFR (estimated GFR) calculation, however infection and inflammation markers influence should be included. A risk assessment of the appearance of cardiovascular incidents and risks of the all-cause mortality can be the other application for this parameter. The urinary CysC concentration can serve as the diagnostic marker of kidney tubular injuries triggered with adverse effects of antiretroviral drugs eg. tenofovir. In order to introduce applications into the routine clinical practice, further research is essential. Research concerning antiviral activity of cystatin C suggest, that CysC suppresses the viral replication due to inhibition of HIV protease, but in some cases its inhibitory effect on cathepsin B may be harmful and cause progression of the infection. In order that CysC could effectively use in the future, further experiments are needed to evaluate its effect on all sort virus strains, both dependent and independent of CD4+ T-lymphocytes, strains of the HIV virus.

scholarly journals Genome-wide significant locus of beta-trace protein, a novel kidney function biomarker, identified in European and African Americans

2013 ◽  
Vol 28 (6) ◽  
pp. 1497-1504 ◽  
Author(s):  
Adrienne Tin ◽  
Brad C. Astor ◽  
Eric Boerwinkle ◽  
Ron C. Hoogeveen ◽  
Josef Coresh ◽  
...  
Keyword(s):  
African Americans ◽  
Kidney Function ◽  
Protein A ◽  
Genome Wide ◽  
Significant Locus

scholarly journals CIM: Beyond a new start

2009 ◽  
Vol 32 (6) ◽  
pp. 224
Author(s):  
Bing Siang Gan
Keyword(s):  
Open Access ◽  
Clinical Investigation ◽  
Hard Copy ◽  
Official Journal ◽  
Original Research ◽  
New Era ◽  
The Past ◽  
On Line ◽  
Investigative Medicine ◽  
The University

This issue marks the last edition of Clinical and Investigative Medicine under the leadership of Dr. David Bevan. Dr. Bevan has been the Editor-in-Chief of CIM for the past six years. During this time, CIM, as the official journal of the Canadian Society for Clinical Investigation, underwent several major changes. First, CIM was bought from the CMA and is now independently produced. Second, CIM went from a hard copy journal to an on-line journal with open access six months after publication of each issue. Third, the journal now levies publication page charges from its authors with members of CSCI exempted from these charges. Dr. Bevan succeeded in not only maintaining CIM as a MedLine and PubMed referenced journal, but also in increasing its prominence as an open access type on-line journal, while at the same time turning around its finances. The number of submissions to CIM has more than doubled since CIM instituted these changes, and CIM went from a deficit journal to making a small profit: a true great beginning of a new era for CIM. We thank Dr. Bevan for his important contributions. With the retirement of Dr. Bevan, CSCI is happy to announce that Dr. Jonathan Angel from Ottawa will take over from Dr. Bevan as Editor-in-Chief from January 1, 2010. Dr. Angel is a Professor of Medicine at the University of Ottawa and a recognized expert in infectious diseases. He is widely published and brings a wealth of expertise to CIM. Under the stewardship of Dr. Angel, CIM will build on the foundation laid by Dr. Bevan and will continue to publish high quality original research related to any aspect of clinical investigation. At CSCI, we are all looking forward to working with Dr. Angel to increase CIM’s scope and impact factor. We are convinced that Dr. Angel will have a successful tenure at CIM and look forward to seeing the Journal grow further.

scholarly journals Impact of Ramadan fasting on kidney function and related outcomes in patients with chronic kidney disease: a systematic review protocol

BMJ Open ◽  
2019 ◽  
Vol 9 (8) ◽  
pp. e022710 ◽  
Author(s):  
Aminu K Bello ◽  
Julia Kurzawa ◽  
Mohamed A Osman ◽  
Michelle E Olah ◽  
Anita Lloyd ◽  
...  
Keyword(s):  
Systematic Review ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Kidney Function ◽  
Grey Literature ◽  
Kidney Injury ◽  
Religious Practice ◽  
Risk Of Bias ◽  
Original Research ◽  
Ramadan Fasting

IntroductionFasting during the month of Ramadan is a significant Islamic religious practice that involves abstinence from food, drink and medication from dawn to dusk. As just under a quarter of the world’s population identifies as Muslim, the effect of fasting on chronic conditions, such as chronic kidney disease (CKD) is a topic of broad relevance. To date, the information in this area has been mixed, with many limitations of previous studies. This study aims to synthesise the evidence of the effect of Ramadan fasting on changes on kidney function, risk factors, episodes of acute kidney injury and impact on the quality of life in patients with CKD or kidney transplant.Methods and analysisA systematic review of the literature will be conducted, using electronic databases such as MEDLINE, Embase, Global Health, CINAHL and Scopus. Original research and grey literature on the effect of Ramadan fasting in adult patients with CKD or renal transplantation will be included. Two reviewers will independently screen articles for inclusion in the review and independently assess the methodology of included studies using a customised checklist. Mean difference or risk ratio will be reported for continuous or dichotomous outcomes and results will be pooled using a random-effects model where heterogeneity is reasonable. If possible, subgroups (CKD status, setting, season and risk of bias) will be analysed for effect modification with fasting and the outcomes of interest. Risk of bias will be assessed using the Downs and Black checklist.Ethics and disseminationThe results will be disseminated using a multifaceted approach to engage all stakeholders (patients, practitioners and community leaders). Research ethics board approval is not required as this is a systematic review of previously published research.PROSPERO registration numberCRD42018088973.

Scientific progress is like doing a puzzle, not building a wall

2018 ◽  
Vol 41 ◽  
Author(s):  
Alexa M. Tullett ◽  
Simine Vazire
Keyword(s):  
Scientific Progress ◽  
Original Research ◽  
Jigsaw Puzzle ◽  
Replication Research

AbstractWe contest the “building a wall” analogy of scientific progress. We argue that this analogy unfairly privileges original research (which is perceived as laying bricks and, therefore, constructive) over replication research (which is perceived as testing and removing bricks and, therefore, destructive). We propose an alternative analogy for scientific progress: solving a jigsaw puzzle.

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