The relationships between HDL mean particle size and serum paraoxonase activity

2011 ◽  
Vol 44 (13) ◽  
pp. S49
Author(s):  
Amir Nader Emami Razavi ◽  
Mohsen Ani ◽  
Gholam Ali Naderi ◽  
Morteza Pourfarzam
Keyword(s):  
Particle Size ◽  
Paraoxonase Activity ◽  
Mean Particle Size ◽  
Serum Paraoxonase

Application of Plakett-Burman Screening Design in Optimization of Process Parameters for Formulation of Canaglifozin Nanosuspension

2020 ◽  
Vol 13 (6) ◽  
pp. 5208-5216
Author(s):  
Nisha Patel ◽  
Hitesh A Patel
Keyword(s):  
Particle Size ◽  
Particle Diameter ◽  
Spherical Shape ◽  
Water Soluble ◽  
Pareto Chart ◽  
Independent Variables ◽  
Mean Particle Size ◽  
Screening Design ◽  
Stirring Time ◽  
Response Variables

In this study, we sought to improve the dissolution characteristics of a poorly water-soluble BCS class IV drug canaglifozin, by preparing nanosuspension using media milling method. A Plackett–Burman screening design was employed to screen the significant formulation and process variables. A total of 12 experiment were generated by design expert trial version 12 for screening 5 independent variables namely the amount of stabilizer in mg (X1), stirring time in hr (X2), amt of Zirconium oxide beads in gm (X3), amount of drug in mg (X4) and stirring speed in rpm (X5) while mean particle size in nm (Y1) and drug release in 10 min. were selected as the response variables. All the regression models yielded a good fit with high determination coefficient and F value. The Pareto chart depicted that all the independent variables except the amount of canaglifozin had a significant effect (p<0.001) on the response variables. The mathematical model for mean particle size generated from the regression analysis was given by mean particle size = +636.48889 -1.28267 amt of stabilizer(X1) -4.20417 stirring time (X2) -7.58333 amt of ZrO2 beads(X3) -0.105556 amt of drug(X4) -0.245167 stirring speed(X5) (R2=0.9484, F ratio=22.07, p<0.001). Prepared canaglifozin nanosuspension exemplified a significant improvement (p<0.05) in the release as compared to pure canaglifozin and marketed tablet with the optimum formulation releasing almost 80% drug within first 10min. Optimized nanosuspension showed spherical shape with surface oriented stabilizer molecules and a mean particle diameter of 120.5 nm. There was no change in crystalline nature after formulation and it was found to be chemically stable with high drug content.

scholarly journals Methylmercury exposure, PON1 gene variants and serum paraoxonase activity in Eastern James Bay Cree adults

2014 ◽  
Vol 24 (6) ◽  
pp. 608-614 ◽  
Author(s):  
Olivia Drescher ◽  
Eric Dewailly ◽  
Caroline Diorio ◽  
Nathalie Ouellet ◽  
Elhadji Anassour Laouan Sidi ◽  
...  
Keyword(s):  
Gene Variants ◽  
James Bay ◽  
Paraoxonase Activity ◽  
Pon1 Gene ◽  
James Bay Cree ◽  
Methylmercury Exposure ◽  
Serum Paraoxonase

Serum paraoxonase activity is decreased in uremic patients

1996 ◽  
Vol 247 (1-2) ◽  
pp. 71-80 ◽  
Author(s):  
Renzo Schiavon ◽  
Emanuela De Fanti ◽  
Davide Giavarina ◽  
Stefano Biasioli ◽  
Gaetano Cavalcanti ◽  
...  
Keyword(s):  
Paraoxonase Activity ◽  
Uremic Patients ◽  
Serum Paraoxonase

Reduced graphene oxide/nano-Bioglass composites: processing and super-anion oxide evaluation

RSC Advances ◽  
2016 ◽  
Vol 6 (24) ◽  
pp. 19657-19661 ◽  
Author(s):  
C. Ashok raja ◽  
S. Balakumar ◽  
D. Durgalakshmi ◽  
R. P. George ◽  
B. Anandkumar ◽  
...  
Keyword(s):  
Particle Size ◽  
Graphene Oxide ◽  
Reduced Graphene Oxide ◽  
Mean Particle Size ◽  
Reduced Graphene ◽  
Composites Processing ◽  
45S5 Bioglass

45S5 Bioglass with a mean particle size in the nano regime was synthesized and fabricated with rGO sheets using three different strategies.

scholarly journals Biases Associated with Four Stream Substrate Samplers

1991 ◽  
Vol 48 (10) ◽  
pp. 1882-1886 ◽  
Author(s):  
Michael K. Young ◽  
Wayne A. Hubert ◽  
Thomas A. Wesche
Keyword(s):  
Particle Size ◽  
Geometric Mean ◽  
The Other ◽  
Substrate Composition ◽  
Mean Particle Size ◽  
Core Samples ◽  
Freeze Core ◽  
Single Probe ◽  
Core Sampler ◽  
Stream Substrate

We compared samples collected from 10 substrates of various compositions with a single-probe freeze-core sampler, a triple-probe freeze-core sampler, a McNeil sampler, and a shovel. The accuracy with which these devices sampled particles larger than 50 mm in diameter varied; they were oversampled by the freeze-core devices, sampled in proportion to their availability by a shovel, and sampled inconsistently by the McNeil sampler. The geometric mean particle size and variance of single-probe freeze-core samples consistently exceeded those of samples collected with the other devices. Most sample means also exceeded the test substrate means. By excluding the proportions of particles larger than 50 mm in diameter in our analyses, we found that proportions of several particles sizes in samples collected by different methods differed significantly from the actual proportions in test substrates. There were few differences between the single- and triple-probe freeze-core samples or between McNeil and shovel samples. All four samplers were biased, but the McNeil sampler most frequently produced samples that approximated the true substrate composition.

A SIMULATION STUDY ON THE EFFECT OF PARTICLE SIZE DISTRIBUTION ON THE PRINTED GEOMETRY IN SELECTIVE LASER MELTING

2021 ◽  
pp. 1-14
Author(s):  
Vaishak Ramesh Sagar ◽  
Samuel Lorin ◽  
Johan Göhl ◽  
Johannes Quist ◽  
Christoffer Cromvik ◽  
...  
Keyword(s):  
Particle Size ◽  
Particle Size Distribution ◽  
Size Distribution ◽  
Layer Thickness ◽  
Selective Laser Melting ◽  
Laser Melting ◽  
Powder Bed ◽  
Mean Particle Size ◽  
Final Layer ◽  
Effect Of Particle Size

Abstract Selective laser melting (SLM) process is a powder bed fusion additive manufacturing process that finds applications in aerospace and medical industries for its ability to produce complex geometry parts. As the raw material used is in powder form, particle size distribution (PSD) is a significant characteristic that influences the build quality in turn affecting the functionality and aesthetics aspects of the product. This paper investigates the effect of PSD on the printed geometry for 316L stainless steel powder, where three coupled in-house simulation tools based on Discrete Element Method (DEM), Computational Fluid Dynamics (CFD), and Structural Mechanics are employed. DEM is used for simulating the powder bed distribution based on the different powder PSD. The CFD is used as a virtual testbed to determine thermal parameters such as heat capacity and thermal conductivity of the powder bed viewed as a continuum. The values found as a stochastic function of the powder distribution is used to analyse the effect on the melted zone and deformation using Structural Mechanics. Results showed that mean particle size and PSD had a significant effect on the packing density, melt pool layer thickness, and the final layer thickness after deformation. Specifically, a narrow particle size distribution with smaller mean particle size and standard deviation produced solidified final layer thickness closest to nominal layer thickness. The proposed simulation approach and the results will catalyze in development of geometry assurance strategies to minimize the effect of particle size distribution on the geometric quality of the printed part.

Effect of Ag addition in Sn on growth of SnTe compound during reaction between molten solder and tellurium

2010 ◽  
Vol 25 (2) ◽  
pp. 391-395 ◽  
Author(s):  
Chien-Neng Liao ◽  
Yen-Chun Huang
Keyword(s):  
Particle Size ◽  
Reaction Time ◽  
Electrical Properties ◽  
Bismuth Telluride ◽  
Molten Solder ◽  
Thermoelectric Modules ◽  
Ag Addition ◽  
Mean Particle Size ◽  
Mechanical And Electrical Properties ◽  
The Mean

SnTe is the most common compound formed at the bismuth telluride/metal soldered junction of thermoelectric modules. It affects the mechanical and electrical properties of the soldered junction. In the study we investigate the growth of SnTe compound during reaction between molten Sn–3.5Ag solder and tellurium at 250 °C. We found that the growth of SnTe is suppressed by Ag–Te bilayer compounds that block further reaction between liquid Sn and Te. With increasing reaction time, the SnTe morphology becomes rough as a result of coarsening of SnTe grains. The growth of SnTe grains follows the conservative ripening kinetics with the mean particle size proportional to one-third power of reaction time.

Sign in / Sign up

Export Citation Format

Share Document