Cutaneous drug eruptions including serum sickness-like reaction, symmetrical drug-related intertriginous and flexural exanthema, and drug-induced lupus

2020 ◽  
Vol 38 (6) ◽  
pp. 641-647 ◽  
Author(s):  
Kyle McNamara ◽  
Olivia Bosshardt Hughes ◽  
Lindsay Chaney Strowd
Keyword(s):  
Serum Sickness ◽  
Drug Induced ◽  
Drug Eruptions

scholarly journals A Review of Adverse Cutaneous Drug Reactions Resulting from the Use of Interferon and Ribavirin

2009 ◽  
Vol 23 (10) ◽  
pp. 677-683 ◽  
Author(s):  
Nisha Mistry ◽  
Jonathan Shapero ◽  
Richard I Crawford
Keyword(s):  
Side Effects ◽  
Drug Reactions ◽  
Drug Induced ◽  
Common Cause ◽  
Injection Site Reactions ◽  
Drug Eruptions ◽  
Fixed Drug ◽  
Life Threatening ◽  
Cutaneous Drug Reactions ◽  
Systemic Drug

Drug-induced cutaneous eruptions are named among the most common side effects of many medications. Thus, cutaneous drug eruptions are a common cause of morbidity and mortality, especially in hospital settings. The present article reviews different presentations of drug-induced cutaneous eruptions, with a focus on eruptions reported secondary to the use of interferon and ribavirin. Presentations include injection site reactions, psoriasis, eczematous drug reactions, alopecia, sarcoidosis, lupus, fixed drug eruptions, pigmentary changes and lichenoid eruptions. Also reviewed are findings regarding life-threatening systemic drug reactions.

Cutaneous reactions to drugs

2020 ◽  
pp. 5752-5760
Author(s):  
Sarah Walsh ◽  
Daniel Creamer ◽  
Haur Yueh Lee
Keyword(s):  
Adverse Drug Reactions ◽  
Adverse Reactions ◽  
Normal Function ◽  
Stevens Johnson Syndrome ◽  
Drug Reactions ◽  
Drug Induced ◽  
Drug Eruptions ◽  
Fixed Drug ◽  
Iatrogenic Illness ◽  
Systemic Symptoms

Adverse reactions to medications are common and important cause of iatrogenic illness. Severe cutaneous adverse drug reactions include toxic epidermal necrolysis, Stevens–Johnson syndrome, drug reaction with eosinophilia and systemic symptoms, and acute generalized exanthematous pustulosis, which together constitute 2% of all adverse drug reactions and may be life-threatening. Less severe drug-induced skin reactions such as exanthems, urticaria, lichenoid drug rashes, and fixed drug eruptions are more common, sometimes termed benign cutaneous adverse reactions, and generally resolve without sequelae. Drugs may also cause adverse events due to alteration of the normal function of the skin or its appendages. This may take the form of photosensitivity, abnormal pigmentation, or disrupted growth of hair or nails.

scholarly journals Ofloxacin/ tinidazole induced fixed drug eruption- a case report

2021 ◽  
Vol 2 (1) ◽  
pp. 36-38
Author(s):  
Monika Kapoor
Keyword(s):  
Adverse Drug Reaction ◽  
Case Report ◽  
Drug Eruption ◽  
Fixed Drug Eruption ◽  
Drug Induced ◽  
Drug Eruptions ◽  
Fixed Drug ◽  
Causative Agents ◽  
Inflammatory Drugs ◽  
Cutaneous Adverse Drug Reaction

Introduction: An immunological cutaneous adverse drug reaction is distinguished as sharply defined lesions with red rashes and sharp borders, erythematous lesions with or without blisters developing within an hour or in a few cases within a week after drug administration is termed as fixed drug eruptions (FDE). FDE is one of the major forms of drug-induced dermatosis. Various class of drugs that are causative agents for FDE includes antibiotics, anticonvulsants, antivirals, and Non-steroidal anti-inflammatory drugs (NSAID). FDE is easily recognized and differentiated from other drug eruptions since it does not occur voluntarily or during infection. Case report: This case report is to spotlight the case of a 52-year-old male patient who was undergoing treatment for acute gastroenteritis and suffered from FDE due to administration of IV Ofloxacin.

scholarly journals Serum Sickness-Like Reaction: Drug-Induced Cutaneous Disease in a Child

2021 ◽  
pp. 2021029
Author(s):  
Ana Carolina Galvão dos Santos de Araujo ◽  
Liana Moura de Almeida ◽  
Ana Paula Moura de Almeida ◽  
Elisa Fontenelle de Oliveira ◽  
Mayra Carrijo Rochael ◽  
...  
Keyword(s):  
Serum Sickness ◽  
Drug Induced ◽  
Cutaneous Disease

scholarly journals AN ANTIBIOTIC DRUG-INDUCED ALLERGIC REACTION IN A PATIENT WITH MULTIPLE COMORBIDITIES. CLINICAL CASE

2020 ◽  
pp. 211-214
Author(s):  
G. E. Kuodza ◽  
P. O. Kolesnyk
Keyword(s):  
Allergic Reaction ◽  
Management Plan ◽  
Medical Attention ◽  
Allergic Reactions ◽  
Drug Induced ◽  
Delayed Reaction ◽  
Provocation Tests ◽  
Drug Eruptions ◽  
Antibiotic Drug

Drug induced allergic reactions due to antibiotics rarely occur. Penicillin is the antibiotic class that is mostly commonly associated with drug induced allergic reactions (10 %). They are followed by quinolones (2 %) which will be discussed in this case based review. Fluoroquinolones allergic reactions can either present as an immediate reaction which requires urgent medical attention or a delayed reaction. Among the antibiotics of this class, moxifloxacin has been reported as the drug which is likely to result in occurrence of an allergic reaction. Some of the dermatologic eruptions that could manifest include maculopapular exanthema, urticarial, Steven Johnson Syndrome, fixed drug eruptions and drug rash with eosinophilia and systemic symptoms (DRESS). The diagnosis needs a thorough history and physical examination, skin test, in vitro testing and drug provocation tests. Management includes discontinuation of the provoking agent and administration of antihistamines or corticosteroids depending on the situation. The case of the 75 year old lady who had an allergic reaction following administrations of ciprofloxacin and follow up management plan is described in the article. The case illustrates and urgent necessity of quaternary prevention in primary care to avoid harming patients while choosing the best and safe therapy.

An Update on the Management of Severe Cutaneous Drug Hypersensitivity Reactions

2019 ◽  
Vol 25 (36) ◽  
pp. 3881-3901
Author(s):  
Aslı Gelincik ◽  
Ozlem Cavkaytar ◽  
Semanur Kuyucu
Keyword(s):  
Large Scale ◽  
Drug Hypersensitivity ◽  
Treatment Options ◽  
Serum Sickness ◽  
Morbidity And Mortality ◽  
Stevens Johnson Syndrome ◽  
Hypersensitivity Reactions ◽  
Drug Eruptions ◽  
Number Of Patients ◽  
Drug Hypersensitivity Reactions

Severe cutaneous drug hypersensitivity reactions involve of different mechanisms , some of which are life-threatening, such as Stevens-Johnson syndrome/toxic epidermal necrolysis, drug reaction with eosinophilia and systemic symptoms, acute generalized exanthematous pustulosis, generalized bullous fixed drug eruptions, serum sickness and serum sickness-like reaction and drug-induced vasculitis. These reactions may have substantial morbidity and mortality. In the past years, successive studies have provided new evidence regarding the pathogenesis of some of these severe reactions and revealed that underlying mechanisms are highly variable. Since these reactions have unique presentations and distinct pathomechanisms, the treatment methods and response rates might be different among various entities. Although supportive and local therapies are sufficient in some of these reactions, targeted immunosuppressive treatments and even mechanistic therapies such as plasmapheresis may be required in severe ones. However, there is still insufficient evidence to support the best treatment options for these patients since number of patients and large-scale studies are limited. In this review, conventional and new treatment options for severe cutaneous drug hypersensitivity reactions are presented in detail in order to provide the contemporary approaches to lessen the morbidity and mortality relevant to these severe iatrogenic diseases.

scholarly journals Drug eruptions and hepatic involvement: a study

2018 ◽  
Vol 4 (4) ◽  
pp. 501
Author(s):  
Vimala Manne ◽  
Padmaja Pinjala
Keyword(s):  
Liver Function ◽  
Liver Function Test ◽  
Liver Function Tests ◽  
Drug Induced ◽  
Medical College ◽  
Hepatic Involvement ◽  
Function Tests ◽  
Drug Eruptions ◽  
Function Test ◽  
Drug Rash

<p class="abstract"><strong>Background:</strong> Assessment by liver biopsy remains the gold standard in defining drug induced liver disease. Liver biopsy is an invasive procedure. Hence, a technique that is simpler is required to detect drug induced liver dysfunction. The profile of liver function tests (LFT) abnormalities, provides an initial guide to the clinical syndrome of drug induced hepatotoxicity. This study attempts to draw a possible correlation as well as to derive insight into the involvement of liver in drug eruptions through simple liver function tests.</p><p class="abstract"><strong>Methods:</strong> 112 cases of patients with drug rash whom we have a tendency to saw within the department of medicine as out-patients and in-patients since 2015 to 2018 in Osmania General Hospital, Katuri Medical College and Hospital and Dr. V. R. K Women’s Medical College, Teaching Hospital and Research Centre were enclosed during this study. Total number of cutaneous drug rash cases enrolled: 83 Total number of drug rash cases with Liver Function Test abnormalities: 17.<strong></strong></p><p class="abstract"><strong>Results:</strong> Out of 83 patients of drag rash 20% (17) had liver function test abnormalities while 80% (66) had normal hepatic function. Out of 17 drug rash cases with liver function test abnormalities 35% (6) were between 4-14 years of age group. Out of 17 drug rash cases with liver function test abnormalities 70.6% (12) were males and 29.4% (5) were females.</p><p class="abstract"><strong>Conclusions:</strong> To conclude, a sound knowledge of morphological patterns of drug rashes with hepatic involvement, drugs implicated in causing drug rashes and hepatic dysfunction and an easy detection of impending danger by the simple biochemical tests (liver function tests) can evert a major crisis and thus help the clinicians to better manage their cases.</p>

scholarly journals Amoxicillin induced erythematous maculopapular rashes: a case report

2020 ◽  
Vol 9 (5) ◽  
pp. 806
Author(s):  
Dhakchinamoorthi Krishna Kumar ◽  
Ravichandran Rajganesh ◽  
Dilli Batcha Jaya Shree ◽  
Sam Nikhil Cherian ◽  
Thayub Mohamed
Keyword(s):  
Adverse Drug Reaction Reporting ◽  
Stevens Johnson Syndrome ◽  
Beta Lactam ◽  
Drug Induced ◽  
Drug Eruptions ◽  
Immune Mediated ◽  
Johnson Syndrome ◽  
Lactam Antibiotic ◽  
Cutaneous Reactions ◽  
Maculopapular Rashes

Cutaneous adverse reactions (CAR) can occur with any class of drugs, however more widely caused by various antibiotics. Amoxicillin is a broad-spectrum, bactericidal, beta-lactam antibiotic, widely used for combating various infections. Cutaneous drug eruptions are known to be reported common while using penicillin class of drugs, specifically among children. These immune-mediated bizarre drug eruptions were range from mild to severe drug-induced cutaneous reactions, such as Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). The present case reported with maculopapular, erythematous rashes induced by amoxicillin in a nine-year-old male patient. Amoxicillin was prescribed for his hyperactive respiratory disease and subsequently after three days developed generalized maculopapular erythematous rashes as a result of an antibiotic-induced skin rash. The present case is being reported to add more data, also to emphasize and gather the information for evidence-based practice and to promote efficient pharmacovigilance adverse drug reaction reporting.

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