Intraoperative contrast-enhanced ultrasound for cerebral glioma resection and the relationship with microvessel density

ABSTRACTPurposeWe studied the value of intraoperative contrast-enhanced ultrasound (iCEUS) for real-time monitoring of resection of cerebral gliomas, and analyzed the relationship between CEUS parameters and microvessel density (MVD) of different pathologic grades of cerebral gliomas.Materials and MethodsICEUS was performed in 49 patients with cerebral gliomas. The enhancement characteristics of cerebral gliomas were observed before and after tumor resection. The number of microvessels was counted by immunostaining with anti-CD34. Differences in these quantitative parameters in cerebral gliomas were compared and subjected to a correlation analysis with MVD.ResultsThe color Doppler flow classification within lesions were significantly different before and after iCEUS (p<0.05). The assessment of iCEUS parameters and tumor MVD showed that cerebral gliomas of different pathological grades had different characteristics. The time-to-peak (Tmax) was significantly shorter, the peak intensity (PI) and MVD were significantly higher in high-grade cerebral gliomas than in low-grade cerebral gliomas (p<0.05). According to the immunostaining, PI was positively (r=0.637) correlated with MVD and Tmax was negatively (r=–0.845) correlated with MVD.ConclusionICEUS may determine the borders of lesions more clearly, indicate the microvascular perfusion in real time, and be helpful in understanding the cerebral gliomas grade.

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Intraoperative contrast-enhanced ultrasound for cerebral glioma resection and the relationship between microvascular perfusion and microvessel density

Clinical Neurology and Neurosurgery ◽

10.1016/j.clineuro.2019.105512 ◽

2019 ◽

Vol 186 ◽

pp. 105512

Author(s):

Jia Wang ◽

Yilin Yang ◽

Xi Liu ◽

Yunyou Duan

Keyword(s):

Microvessel Density ◽

Microvascular Perfusion ◽

Cerebral Glioma ◽

Contrast Enhanced Ultrasound ◽

Contrast Enhanced ◽

Glioma Resection ◽

The Relationship

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Integration of Real-Time Intraoperative Contrast-Enhanced Ultrasound and Color Doppler Ultrasound in the Surgical Treatment of Spinal Cord Dural Arteriovenous Fistulas

World Neurosurgery ◽

10.1016/j.wneu.2018.01.101 ◽

2018 ◽

Vol 112 ◽

pp. 138-142 ◽

Cited By ~ 10

Author(s):

Giuseppe Maria Della Pepa ◽

Giovanni Sabatino ◽

Carmelo Lucio Sturiale ◽

Enrico Marchese ◽

Alfredo Puca ◽

...

Keyword(s):

Spinal Cord ◽

Surgical Treatment ◽

Real Time ◽

Doppler Ultrasound ◽

Color Doppler ◽

Color Doppler Ultrasound ◽

Contrast Enhanced Ultrasound ◽

Arteriovenous Fistulas ◽

Contrast Enhanced ◽

Dural Arteriovenous Fistulas

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The Role of Real-Time Contrast-Enhanced Ultrasound in Guiding Radiofrequency Ablation of Reninoma: Case Report and Literature Review

Frontiers in Oncology ◽

10.3389/fonc.2021.585257 ◽

2021 ◽

Vol 11 ◽

Author(s):

Rui Zhang ◽

Ming Xu ◽

Xiao-yan Xie

Keyword(s):

Radiofrequency Ablation ◽

Real Time ◽

Endocrine Tumor ◽

Young Female ◽

Secondary Hypertension ◽

Contrast Enhanced Ultrasound ◽

Ultrasound Guided ◽

Promising Alternative ◽

Contrast Enhanced ◽

Before And After

BackgroundReninoma is a rare renal endocrine tumor that can cause secondary hypertension, characterized by hypertension, hypokalemia, high renin and aldosterone with normal aldosterone renin ratio (ARR), and occurs more in young female. Mainstream treatment option is surgery, but is less suitable for small or deep lesions, which makes ablation a promising alternative.Case presentationTwo young female with typical manifestations of reninoma, including hypertension, hypokalemia, high renin, high aldosterone and normal ARR, were treated successfully with real-time contrast-enhanced ultrasound guided radiofrequency ablation, and contrast-enhanced ultrasound was also performed before and after treatment for diagnosis and postoperative assessment. Afterward, their blood pressure and laboratory tests became normal and remained steady during the follow-up of 32 and 6 months, respectively.ConclusionContrast-enhanced ultrasound guided radiofrequency ablations is a promising alternative for reninoma treatment with comparable safety and efficacy with surgery, and has advantages especially in small or deep lesions.

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Contrast-enhanced ultrasound of the abdominal aorta – current status and future perspectives

VASA ◽

10.1024/0301-1526/a000749 ◽

2019 ◽

Vol 48 (2) ◽

pp. 115-125 ◽

Cited By ~ 4

Author(s):

Xin Li ◽

Daniel Staub ◽

Vasileios Rafailidis ◽

Mohammed Al-Natour ◽

Sanjeeva Kalva ◽

...

Keyword(s):

Real Time ◽

Vascular Diseases ◽

Aneurysm Rupture ◽

Vasa Vasorum ◽

Current Status ◽

Contrast Enhanced Ultrasound ◽

Aortic Diseases ◽

Cross Sectional ◽

Vascular Abnormalities ◽

Contrast Enhanced

Abstract. Ultrasound has been established as an important diagnostic tool in assessing vascular abnormalities. Standard B-mode and Doppler techniques have inherent limitations with regards to detection of slow flow and small vasculature. Contrast-enhanced ultrasound (CEUS) is a complementary tool and is useful in assessing both the macro- and microvascular anatomy of the aorta. CEUS can also provide valuable physiological information in real-time scanning sessions due to the physical and safety profiles of the administered microbubbles. From a macrovascular perspective, CEUS has been used to characterize aortic aneurysm rupture, dissection and endoleaks post-EVAR repair. With regard to microvasculature CEUS enables imaging of adventitial vasa vasorum thereby assessing aortic inflammation processes, such as monitoring treatment response in chronic periaortitis. CEUS may have additional clinical utility since adventitial vasa vasorum has important implications in the pathogenesis of aortic diseases. In recent years, there have been an increasing number of studies comparing CEUS to cross-sectional imaging for aortic applications. For endoleak surveillance CEUS has been shown to be equal or in certain cases superior in comparison to CT angiography. The recent advancement of CEUS software along with the ongoing development of drug-eluting contrast microbubbles has allowed improved targeted detection and real-time ultrasound guided therapy for aortic vasa vasorum inflammation and neovascularization in animal models. Therefore, CEUS is uniquely suited to comprehensively assess and potentially treat aortic vascular diseases in the future.

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