Magnetic resonance imaging criteria for prediction of isocitrate dehydrogenase mutation (IDH) status in patients with Grade II-III astrocytoma and oligodendroglioma

Magnetic Resonance Imaging (MRI) is a widely accessible imaging technique for the detection of brain tumours and cancer, which are further confirmed by histopathological examination. Accurate detection of the tumours and its extent is very difficult. The present study attempted to evaluate the convenience of MRI in detection of different grades of astrocytomas, which are the most commonly occurring brain tumours. This cross-sectional study was conducted at the Department of Radiology and Imaging with the collaboration of Department of Neurosurgery and Department of Pathology at Sir Salimullah Medical College (SSMC & MH), Dhaka from January 2013 to December 2013 for a period of one year. The study population was all the diagnosed cases of intracranial astrocytoma patients regardless of their age and sex. The studied included 48 brain tumour (astrocytoma) patients, ages between 13 and 69 years old. All cases having no contraindication for MRI underwent MR examination followed by histopathological examination of the postoperative resected tissues. The findings of the MRI and histopathological examination were compared to find out the test validity of the MRI findings of the different grades of astrocytoma’s. The highest sensitivity was found in grade III astrocytoma (90.5%) followed by grade II (85.7%) grade IV (75.0%) and grade I (60.0%). The highest specificity was found in grade I astrocytoma (97.7%) followed by Grade III (96.3%), grade IV (92.5%) and grade II (91.5%). The highest accuracy was found in both grade I astrocytoma (93.7%) and grade III (93.7%) followed by grade II (92.5%) and grade IV (89.6%). As per the study findings it can be concluded that,MRI has a high diagnostic accuracy and validity for the detection of different grades of astrocytoma. Bangladesh Med J. 2017 Sep; 46 (3): 85-89

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Commentary: Impact of Intraoperative Magnetic Resonance Imaging and Other Factors on Surgical Outcomes for Newly Diagnosed Grade II Astrocytomas and Oligodendrogliomas: A Multicenter Study

Neurosurgery ◽

10.1093/neuros/nyaa337 ◽

2020 ◽

Vol 88 (1) ◽

pp. E29-E30

Author(s):

Jan Coburger

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Multicenter Study ◽

Surgical Outcomes ◽

Newly Diagnosed ◽

Resonance Imaging ◽

Intraoperative Magnetic Resonance Imaging ◽

Grade Ii

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Thin-Slice Magnetic Resonance Imaging-Based Radiomics Signature Predicts Chromosomal 1p/19q Co-deletion Status in Grade II and III Gliomas

Frontiers in Neurology ◽

10.3389/fneur.2020.551771 ◽

2020 ◽

Vol 11 ◽

Author(s):

Ziren Kong ◽

Chendan Jiang ◽

Yiwei Zhang ◽

Sirui Liu ◽

Delin Liu ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Resonance Imaging ◽

Thin Slice ◽

Grade Ii ◽

Radiomics Signature

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Prediction of IDH Status Through MRI Features and Enlightened Reflection on the Delineation of Target Volume in Low-Grade Gliomas

Technology in Cancer Research & Treatment ◽

10.1177/1533033819877167 ◽

2019 ◽

Vol 18 ◽

pp. 153303381987716 ◽

Cited By ~ 4

Author(s):

Haixia Ding ◽

Yong Huang ◽

Zhiqiang Li ◽

Sirui Li ◽

Qiongrong Chen ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Isocitrate Dehydrogenase ◽

Target Volume ◽

Low Grade ◽

Creatinine Ratio ◽

Wild Type ◽

Resonance Imaging ◽

Low Grade Gliomas ◽

Mutational Status

Isocitrate dehydrogenase mutational status defines distinct biologic behavior and clinical outcomes in low-grade gliomas. We sought to determine magnetic resonance imaging characteristics associated with isocitrate dehydrogenase mutational status to evaluate the predictive roles of magnetic resonance imaging features in isocitrate dehydrogenase mutational status and therefore their potential impact on the determination of clinical target volume in radiotherapy. Forty-eight isocitrate dehydrogenase-mutant and 28 isocitrate dehydrogenase–wild-type low-grade gliomas were studied. Isocitrate dehydrogenase mutation was related to more frequency of cortical involvement compared to isocitrate dehydrogenase–wild-type group (34/46 vs 6/24, P = .0001). Peritumoral edema was less frequent in isocitrate dehydrogenase–mutant tumors (32.6% vs 58.3% for isocitrate dehydrogenase–wild-type tumors, P = .0381). Isocitrate dehydrogenase–wild-type tumors were more likely to have a nondefinable border, while isocitrate dehydrogenase–mutant tumors had well-defined borders (66.7% vs 39.1%, P = .0287). Only 8 (17.4%) of 46 of the isocitrate dehydrogenase–mutant tumors demonstrated marked enhancement, while this was 66.7% in isocitrate–wild-type tumors ( P < .0001). Choline–creatinine ratio for isocitrate dehydrogenase–wild-type tumors was significantly higher than that for isocitrate dehydrogenase–mutant tumors. In conclusion, frontal location, well-defined border, cortical involvement, less peritumoral edema, lack of enhancement, and low choline–creatinine ratio were predictive for the definition of isocitrate dehydrogenase–mutant low-grade gliomas. Magnetic resonance imaging can provide an advantage in the detection of isocitrate dehydrogenase status indirectly and indicate the need to explore new design for treatment planning in gliomas. Choline–creatinine ratio in magnetic resonance spectroscopy could be a potential more reasonable reference for the new design of delineation of target volume in low-grade gliomas.

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Assessment of Isocitrate Dehydrogenase 1 Genotype and Cell Proliferation in Gliomas Using Multiple Diffusion Magnetic Resonance Imaging

Frontiers in Neuroscience ◽

10.3389/fnins.2021.783361 ◽

2021 ◽

Vol 15 ◽

Author(s):

Yan Xie ◽

Shihui Li ◽

Nanxi Shen ◽

Tongjia Gan ◽

Shun Zhang ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Cell Proliferation ◽

Diffusion Coefficient ◽

Magnetic Resonance ◽

Isocitrate Dehydrogenase ◽

Diffusion Magnetic Resonance Imaging ◽

Wild Type ◽

Resonance Imaging ◽

Isocitrate Dehydrogenase 1 ◽

Ki 67

Objectives: To compare the efficacy of parameters from multiple diffusion magnetic resonance imaging (dMRI) for prediction of isocitrate dehydrogenase 1 (IDH1) genotype and assessment of cell proliferation in gliomas.Methods: Ninety-one patients with glioma underwent diffusion weighted imaging (DWI), multi-b-value DWI, and diffusion kurtosis imaging (DKI)/neurite orientation dispersion and density imaging (NODDI) on 3.0T MRI. Each parameter was compared between IDH1-mutant and IDH1 wild-type groups by Mann–Whitney U test in lower-grade gliomas (LrGGs) and glioblastomas (GBMs), respectively. Further, performance of each parameter was compared for glioma grading under the same IDH1 genotype. Spearman correlation coefficient between Ki-67 labeling index (LI) and each parameter was calculated.Results: The diagnostic performance was better achieved with apparent diffusion coefficient (ADC), slow ADC (D), fast ADC (D∗), perfusion fraction (f), distributed diffusion coefficient (DDC), heterogeneity index (α), mean diffusivity (MD), mean kurtosis (MK), and intracellular volume fraction (ICVF) for distinguishing IDH1 genotypes in LrGGs, with statistically insignificant AUC values from 0.750 to 0.817. In GBMs, no difference between the two groups was found. For IDH1-mutant group, all parameters, except for fractional anisotropy (FA) and D∗, significantly discriminated LrGGs from GBMs (P < 0.05). However, for IDH1 wild-type group, only ADC statistically discriminated the two (P = 0.048). In addition, MK has maximal correlation coefficient (r = 0.567, P < 0.001) with Ki-67 LI.Conclusion: dMRI-derived parameters are promising biomarkers for predicting IDH1 genotype in LrGGs, and MK has shown great potential in assessing glioma cell proliferation.

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Impact of Intraoperative Magnetic Resonance Imaging and Other Factors on Surgical Outcomes for Newly Diagnosed Grade II Astrocytomas and Oligodendrogliomas: A Multicenter Study

Neurosurgery ◽

10.1093/neuros/nyaa320 ◽

2020 ◽

Vol 88 (1) ◽

pp. 63-73 ◽

Cited By ~ 1

Author(s):

Alexander T Yahanda ◽

Bhuvic Patel ◽

Amar S Shah ◽

Daniel P Cahill ◽

Garnette Sutherland ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Tumor Resection ◽

Patient Treatment ◽

Newly Diagnosed ◽

Resonance Imaging ◽

Total Resection ◽

Intraoperative Magnetic Resonance Imaging ◽

Grade Ii ◽

The Impact

Abstract BACKGROUND Few studies use large, multi-institutional patient cohorts to examine the role of intraoperative magnetic resonance imaging (iMRI) in the resection of grade II gliomas. OBJECTIVE To assess the impact of iMRI and other factors on overall survival (OS) and progression-free survival (PFS) for newly diagnosed grade II astrocytomas and oligodendrogliomas. METHODS Retrospective analyses of a multicenter database assessed the impact of patient-, treatment-, and tumor-related factors on OS and PFS. RESULTS A total of 232 resections (112 astrocytomas and 120 oligodendrogliomas) were analyzed. Oligodendrogliomas had longer OS (P < .001) and PFS (P = .01) than astrocytomas. Multivariate analyses demonstrated improved OS for gross total resection (GTR) vs subtotal resection (STR; P = .006, hazard ratio [HR]: .23) and near total resection (NTR; P = .02, HR: .64). GTR vs STR (P = .02, HR: .54), GTR vs NTR (P = .04, HR: .49), and iMRI use (P = .02, HR: .54) were associated with longer PFS. Frontal (P = .048, HR: 2.11) and occipital/parietal (P = .003, HR: 3.59) locations were associated with shorter PFS (vs temporal). Kaplan-Meier analyses showed longer OS with increasing extent of surgical resection (EOR) (P = .03) and 1p/19q gene deletions (P = .02). PFS improved with increasing EOR (P = .01), GTR vs NTR (P = .02), and resections above STR (P = .04). Factors influencing adjuvant treatment (35.3% of patients) included age (P = .002, odds ratio [OR]: 1.04) and EOR (P = .003, OR: .39) but not glioma subtype or location. Additional tumor resection after iMRI was performed in 105/159 (66%) iMRI cases, yielding GTR in 54.5% of these instances. CONCLUSION EOR is a major determinant of OS and PFS for patients with grade II astrocytomas and oligodendrogliomas. Intraoperative MRI may improve EOR and was associated with increased PFS.

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A Comparison of MRI and Clinical Examination of Acute Lateral Ankle Sprains

Foot & Ankle International ◽

10.1177/107110079601700904 ◽

1996 ◽

Vol 17 (9) ◽

pp. 533-537 ◽

Cited By ~ 48

Author(s):

Carol Frey ◽

James Bell ◽

Louis Teresi ◽

Roger Kerr ◽

Keith Feder

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Soft Tissue ◽

Physical Examination ◽

Soft Tissues ◽

Ankle Sprains ◽

Resonance Imaging ◽

Tissue Contrast ◽

Lateral Collateral Ligaments ◽

Grade Ii

Because of its excellent soft tissue contrast and ability to demonstrate soft tissue structures, magnetic resonance imaging is ideally suited to the evaluation of the soft tissues surrounding the ankle, including the lateral collateral ligaments. This study was undertaken to compare the clinical evaluation of 15 patients who suffered inversion injuries of the ankle with the results found on magnetic resonance imaging within 48 hours of the injury. Physical examination was found to be 100% accurate in the diagnosis of grade III ligament injuries but only 25% accurate in the diagnosis of grade II injuries. Clinicians most often underestimate the damage with a grade II ligament tear. Furthermore, other associated injuries, such as significant capsule ruptures and tendon damage, were often overlooked at physical examination.

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