Need of the Hour: Addressing the Challenges of Multi-Drug-Resistant Health Care-Associated Infections and the Role of the Laboratory in Lowering Infection Rates

2018 ◽  
Vol 40 (2) ◽  
pp. 11-16
Author(s):  
Robert L. Sautter ◽  
Diane C. Halstead
2016 ◽  
Vol 2 (5) ◽  
pp. e1600300 ◽  
Author(s):  
Ki Soo Park ◽  
Chen-Han Huang ◽  
Kyungheon Lee ◽  
Yeong-Eun Yoo ◽  
Cesar M. Castro ◽  
...  

Health care–associated infections (HAIs) and drug-resistant pathogens have become a major health care issue with millions of reported cases every year. Advanced diagnostics would allow clinicians to more quickly determine the most effective treatment, reduce the nonspecific use of broad-spectrum antimicrobials, and facilitate enrollment in new antibiotic treatments. We present a new integrated system, polarization anisotropy diagnostics (PAD), for rapid detection of HAI pathogens. The PAD uses changes of fluorescence anisotropy when detection probes recognize target bacterial nucleic acids. The technology is inherently robust against environmental noise and economically scalable for parallel measurements. The assay is fast (2 hours) and performed on-site in a single-tube format. When applied to clinical samples obtained from interventional procedures, the PAD determined the overall bacterial burden, differentiated HAI bacterial species, and identified drug resistance and virulence status. The PAD system holds promise as a powerful tool for near-patient, rapid HAI testing.


2021 ◽  
Vol 30 (3) ◽  
pp. 29-36
Author(s):  
Rana E. Elgabeery ◽  
Radwa A. Eissa ◽  
Sohair M. Soliman ◽  
Naglaa F. Ghoname

Background: As Mobile Phones (MPs) aren’t cleaned routinely and have been touched during patient’s examination, they may become contaminated with hospital pathogens. Objectives: Screen MPs of Health care workers (HCWs) for pathogens and verify the effect of disinfectants in their decontamination. Methods: A questionnaire was submitted by 160 HCWs in Tanta University Hospitals. Samples were taken from their MPs and subjected to pour plate counting before and after disinfection. Standard identification and antibiotic susceptibility of isolates were done. Results: Colony count was greater in MPs used while caring for patients or inside restroom, and was less in regularly cleaned MPs. All tested disinfectants reduced the colony count significantly. Pathogens were isolated from 84.38% of samples and 36.25% of them were Multi-Drug Resistant Organisms (MDROs). Conclusion: Using MPs at critical care areas and restroom may contribute to their contamination with pathogens. Regular disinfection of MPs can reduce this contamination.


2011 ◽  
Vol 34 (1) ◽  
pp. 11-17 ◽  
Author(s):  
Yvonne Kleypas ◽  
Dennis McCubbin ◽  
Elizabeth S. Curnow

2017 ◽  
Vol 45 (7) ◽  
pp. 805-810 ◽  
Author(s):  
Anucha Apisarnthanarak ◽  
David Ratz ◽  
M. Todd Greene ◽  
Thana Khawcharoenporn ◽  
David J. Weber ◽  
...  

Author(s):  
Gene H Burke ◽  
Jacqueline P Butler

The aim of this study was to evaluate the impact of copper-impregnated composite hard surfaces, bed linens and patient gowns on healthcare-associated infections (HAIs). We took in account potentially confounding factors of new construction and Det Norse Veritas Managing Infection Risk (DNV MIR) certification to mitigate risk of HAIs, multi drug resistant organisms (MDRO) and Clostridium difficile HAIs. The study was conducted in the acute care units from three hospitals within a regional healthcare system and these were assessed retrospectively. Facility 1 and Facility 2 shared the circumstance of new construction. Facility 1 and Facility 3 shared the processes of DNV-MIR. Only Facility 1 undertook the intervention of copper-impregnated hard surfaces, bed linens and patient gowns. We compared infection rates (IR) following their normalization per 10,000 patient hospitalization days before and after complete implementation of copper-impregnated composite hard surfaces, bed linens and patient gowns. Facility 1 had a 28% reduction in total C. difficile and MDRO IR, while Facilities 2 and 3 had 103% and 48% increases in total IR respectively. Although the rate changes per facility were not statistically significantly changed from baseline (p>0.05), there was consistent divergence between the IR at the copper enabled facility and the others. As this divergence occurred when other pertinent factors were constant between them, including new construction and new processes for mitigation of infection risks, these outcomes support the contention that copper-impregnated linens and composite hard surfaces were shown to reduce HAI rates.


2007 ◽  
Vol 17 (6) ◽  
pp. 266-271 ◽  
Author(s):  
Diane Gilmour

Healthcare-associated infections (HCAIs) such as Meticillin resistant Staphylococcus aureus (MRSA) and Clostridium difficile (C. dif) are never far from the media headlines. In January 2006 a leaked memo identified the government's concerns that its target of halving MRSA infection rates by April 2008 may not be met (Boseley 2007). During 2004–5, 30 people died following two outbreaks of C. dif at Stoke Mandeville (Boseley 2007). In this article the author will focus on and discuss in detail key components of the new Code of Practice on Health Care Associated Infections (DH 2006a) to show how legislation has provided the framework to ensure that not only do NHS bodies have a duty to comply with this Act but so do we as practitioners.


2015 ◽  
Vol 43 (10) ◽  
pp. 1125-1127 ◽  
Author(s):  
Chetan Jinadatha ◽  
Zehra Hussain ◽  
Timothy A. Erickson ◽  
Frank C. Villamaria ◽  
Laurel A. Copeland ◽  
...  

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