P-NU005. Nerve cross-sectional area as a surrogate marker of peripheral nerve degeneration in amyotrophic lateral sclerosis

2021 ◽  
Vol 132 (8) ◽  
pp. e118
Author(s):  
Toh Tsun Haw ◽  
Nur Adilah Abdul Aziz ◽  
Mohd Azly Yahaya ◽  
Ee Chin Loh ◽  
David Capelle ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Peripheral Nerve ◽  
Surrogate Marker ◽  
Cross Sectional Area ◽  
Nerve Degeneration ◽  
Sectional Area ◽  
Cross Sectional ◽  
Lateral Sclerosis

scholarly journals The Quantitative Assessment of Respiratory Muscles by Computed Tomography in Patients of Amyotrophic Lateral Sclerosis

2021 ◽  
Author(s):  
Di Wu ◽  
Yujia Cao ◽  
Yan Cui ◽  
Baoyu Yuan ◽  
Yijing Guo ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Amyotrophic Lateral Sclerosis ◽  
Respiratory Muscles ◽  
Cross Sectional Area ◽  
Diaphragm Muscle ◽  
Control Group ◽  
Sectional Area ◽  
Cross Sectional ◽  
The Cross ◽  
Lateral Sclerosis

Abstract Objectives Progressive weakness of respiratory muscle is common to patients with amyotrophic lateral sclerosis, which leads to respiratory failure, even death. The evaluation of respiratory muscle is essential to evaluate the severity during the progression of the disease and choose appropriate interventions. This study aimed to evaluate the respiratory muscles change of the patients with amyotrophic lateral sclerosis by regular chest computed tomography. Methods The cross-sectional area of respiratory muscles in amyotrophic lateral sclerosis patients was retrospectively reviewed. The severity of the disease was determined by the value of the amyotrophic lateral sclerosis function score scale. A healthy control group was selected with well-matched to the amyotrophic lateral sclerosis patients. Results Compared with the healthy control group, the cross-sectional area of the diaphragm muscle was lower in amyotrophic lateral sclerosis patients. The reduced cross-sectional area of respiratory muscles has a positive correlation with a lower amyotrophic lateral sclerosis function score. Patients with amyotrophic lateral sclerosis further showed a significant reduction in the cross-sectional area of respiratory muscles after 6-8 months.Conclusions The single-slice axial computed tomography is a fast and reliable method to quantitatively assess the cross-sectional area of respiratory muscles, especially diaphragm muscle, in disease progression.

scholarly journals Cord cross-sectional area at foramen magnum as a correlate of disability in amyotrophic lateral sclerosis

2018 ◽  
Vol 2 (1) ◽  
Author(s):  
Niccolò Piaggio ◽  
Matteo Pardini ◽  
Luca Roccatagliata ◽  
Carlo Scialò ◽  
Corrado Cabona ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Foramen Magnum ◽  
Cross Sectional Area ◽  
Sectional Area ◽  
Cross Sectional ◽  
Lateral Sclerosis

Peripheral Nerves: Not Only Cross-sectional Area in the Era of Radiomics

2020 ◽  
Vol 24 (02) ◽  
pp. 175-180
Author(s):  
Alberto Stefano Tagliafico ◽  
Raquel Prada González ◽  
Federica Rossi ◽  
Bianca Bignotti ◽  
Carlo Martinoli
Keyword(s):  
Nervous System ◽  
Peripheral Nerve ◽  
Peripheral Nervous System ◽  
Internal Control ◽  
Peripheral Nerves ◽  
Imaging Techniques ◽  
Cross Sectional Area ◽  
Sectional Area ◽  
Musculoskeletal Radiology ◽  
Cross Sectional

AbstractThe peripheral nervous system is increasingly being investigated using medical imaging as a complement or in association with electrodiagnostics tests. The application of imaging techniques, such as ultrasound (US) and magnetic resonance imaging (MRI), allows detailed visualization of the peripheral nervous system. According to the European Society of Musculoskeletal Radiology, the use of US for nerve evaluation is strongly encouraged. In addition, the role of US is further enhanced by the wide application of US-guided techniques to diagnose or to treat peripheral nerve disorders.Standard evaluation of peripheral nerves on US usually relies on cross-sectional area evaluation with different cutoff values in the osteofibrous tunnels and outside them. In several anatomical areas, side-to-side comparison is highly recommended because it helps distinguish subtle variations by using the unaffected limb as an internal control.US is widely used to perform US-guided interventional procedures on peripheral nerves. The recent development of radiomics and machine and deep learning applied to peripheral nerves may reveal new insights beyond the capabilities of the human eye. Radiomics may have a role in expanding the diagnostic capabilities of US and MRI in the study of peripheral nerve pathology, especially when the cross-sectional area is not markedly increased.

scholarly journals High-resolution ultrasound in the assessment of peripheral nerves in leprosy: A comparative cross-sectional study

2021 ◽  
Vol 0 ◽  
pp. 1-8
Author(s):  
Kalathummarath Sreejith ◽  
Sarita Sasidharanpillai ◽  
Kidangazhiathmana Ajithkumar ◽  
Reeba Mary Mani ◽  
Anuradha Thalian Chathoth ◽  
...  
Keyword(s):  
High Resolution ◽  
Peripheral Nerve ◽  
Clinical Examination ◽  
Peripheral Nerves ◽  
Cross Sectional Area ◽  
Nerve Function ◽  
Sectional Area ◽  
Cross Sectional ◽  
Function Impairment ◽  
The Cross

Background: Detection of peripheral nerve thickening and nerve function impairment is crucial in the diagnosis and the management of leprosy. Aims and objectives: (1) To document the cross-sectional area, echotexture and blood flow of peripheral nerves in healthy controls and leprosy cases using high-resolution ultrasound, (2) to compare the sensitivities of clinical examination and high-resolution ultrasound in detecting peripheral nerve thickening in leprosy. Methods: Peripheral nerves of 30 leprosy patients and 30 age- and sex-matched controls were evaluated clinically and by high-resolution ultrasound. When the cross-sectional area of a peripheral nerve on high-resolution ultrasound in a leprosy patient was more than the calculated upper bound of the 95% confidence interval for mean for that specific nerve in controls, that particular peripheral nerve was considered to be enlarged. Results: Cross-sectional areas more than 7.1 mm2 for the radial nerve, 8.17 mm2 for ulnar, 10.17 mm2 for median, 9.50 mm2 for lateral popliteal and 11.21mm2 for the posterior tibial nerve were considered as nerve thickening on high-resolution ultrasound. High-resolution ultrasound detected 141/300 (47%) nerves enlarged in contrast to the 60 (20%) diagnosed clinically by palpation (P < 0.001). Clinical examination identified thickening in 31/70 (44.3%) nerves in cases with impairment of nerve function and 29/230 (12.6%) in the absence of nerve function impairment. High-resolution ultrasound detected thickening in 50/70 (71.4%) nerves with impairment of function and in 91/230 (39.6%) nerves without any impairment of function. Limitation: A single-centre study design was the major study limitation. Conclusion: High-resolution ultrasound showed greater sensitivity than clinical examination in detecting peripheral nerve thickening in leprosy cases. High-resolution ultrasound, may therefore improve the sensitivity of the diagnostic criterion of peripheral nerve enlargement in the diagnosis and classification of leprosy.

Morphological and Functional Changes in the Diabetic Peripheral Nerve

2005 ◽  
Vol 95 (5) ◽  
pp. 433-437 ◽  
Author(s):  
Doohi Lee ◽  
Damien M. Dauphinée
Keyword(s):  
Peripheral Nerve ◽  
Tibial Nerve ◽  
Imaging Techniques ◽  
Cross Sectional Area ◽  
Diabetic Patients ◽  
Tarsal Tunnel ◽  
Sectional Area ◽  
Cross Sectional ◽  
Functional Changes ◽  
Chronic Nerve Compression

It has been hypothesized that in individuals with diabetes mellitus the peripheral nerve is swollen owing to increased water content related to increased aldose reductase conversion of glucose to sorbitol. It has further been hypothesized that the tibial nerve in the tarsal tunnel is at risk for chronic nerve compression related to this swelling. We used diagnostic ultrasound to evaluate this hypothesis. Cross-sectional areas of the tibial nerve were measured in diabetic patients with neuropathy and compared with previously reported measurements in nondiabetic patients and diabetic patients without neuropathy. We used the Pressure-Specified Sensory Device (Sensory Management Services LLC, Baltimore, Maryland) to document the presence of neuropathy in 24 diabetic patients (48 limbs). Previous studies have found that the cross-sectional area of the tibial nerve in nondiabetic patients and in diabetic patients without neuropathy is not significantly different. We found that the mean cross-sectional area of the tibial nerve in diabetic patients with neuropathy is significantly greater than that in diabetic patients without neuropathy (24.0 versus 12.0 mm2). Our study highlights the value of newer ultrasound imaging techniques in identifying morphological change in the tibial nerve and confirms that the tibial nerve in the tarsal tunnel is swollen, consistent with chronic compression, in diabetic patients with neuropathy. (J Am Podiatr Med Assoc 95(5): 433–437, 2005)

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