Salivary Biomarkers for the Detection of Malignant Tumors That are Remote from the Oral Cavity

2009 ◽  
Vol 29 (1) ◽  
pp. 71-85 ◽  
Author(s):  
Lenora R. Bigler ◽  
Charles F. Streckfus ◽  
William P. Dubinsky
Keyword(s):  
Oral Cavity ◽  
Malignant Tumors ◽  
Salivary Biomarkers

scholarly journals Primary Oral Malignant Melanoma: Two Case Reports and Review of Literature

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Neeraj Sharma
Keyword(s):  
Malignant Melanoma ◽  
Early Detection ◽  
Oral Cavity ◽  
Tumor Size ◽  
Malignant Tumors ◽  
Case Reports ◽  
Review Of Literature ◽  
Oral Region ◽  
Rare Neoplasm ◽  
Oral Malignant Melanoma

Primary malignant melanoma of the oral cavity is a rare neoplasm. The tumors tend to metastasize or locally invade tissue more readily than other malignant tumors in the oral region. The survival of patients with mucosal melanomas is less than for those with cutaneous melanomas. Tumor size and metastases are related to the prognosis of the disease. Early detection, therefore, is important.

scholarly journals REVIEW OF THE CURRENT STATE OF THE PROBLEM OF PRIMARY DETECTION OF MALIGNANT TUMORS OF THE CAVITY

2019 ◽  
Vol 15 (2) ◽  
pp. 50-55
Author(s):  
Наталья Нуриева ◽  
Natal'ya Nurieva ◽  
Александр Гузь ◽  
Aleksandr Guz ◽  
Александр Захаров ◽  
...  
Keyword(s):  
Oral Cavity ◽  
Head And Neck ◽  
Malignant Tumors ◽  
Malignant Neoplasm ◽  
Diagnostic Procedures ◽  
Primary Diagnosis ◽  
Malignant Neoplasms ◽  
Dental Rehabilitation ◽  
Late Treatment ◽  
Clinically Significant

Subject: malignant neoplasms of the oral cavity, primary detectability, appeal to specialists, terms of treatment before hospitalization. Objective: based on a five-year analysis of the medical records of patients with a verified diagnosis of malignant neoplasm of the oral cavity, to identify significant criteria for primary diagnosis, doctors of the first contact, including non-cancer profile. Methodology. Malignant neoplasms occupy one of the leading places among all medical and social problems. This is due to a number of reasons, among which are particularly high rates of morbidity and mortality, late treatment of patients and frequent disability. the Purpose of early detection of malignant tumors of the oral cavity is to increase the effectiveness and radicality of treatment, increase the possibility of dental rehabilitation, reduction of disability. To write this article, we conducted a five-year analysis of the primary detection of malignant tumors of the oral cavity in 76 patients hospitalized for treatment in the head and neck Department of the Chelyabinsk district Oncology center. All patients with histologically confirmed diagnosis. Everyone needs specialized anti-tumor treatment. In addition to standard diagnostic procedures, all patients were surveyed on the issues of primary complaints and appeals to medical specialists. Results. On the example of the received questionnaires as well as the standard medical examinations conducted upon admission to the head and neck Department, the trends of the primary referral of patients to primary contact doctors, the terms of treatment before referral to a specialized oncological institution, the stage of the process and the presence of metastasis of the primary focus during treatment, the presence of aggravating factors are analyzed. Conclusions. The results for the five-year period in patients with primary malignant neoplasm of the oral cavity were evaluated, practical recommendations on clinically significant symptoms of malignant tumors of the oral cavity, orientation on the timing of observation were given.

scholarly journals Alternative Therapeutic Approach in the Treatment of Oral Pyogenic Granuloma

2015 ◽  
Vol 8 (3) ◽  
pp. 493-497 ◽  
Author(s):  
Amr Bugshan ◽  
Harsh Patel ◽  
Karen Garber ◽  
Timothy F. Meiller
Keyword(s):  
Oral Cavity ◽  
Malignant Tumors ◽  
Surgical Excision ◽  
Pyogenic Granuloma ◽  
Hormonal Imbalance ◽  
Choice Of Treatment ◽  
Chronic Irritation ◽  
Multiple Recurrences ◽  
And Behavior ◽  
Rule Out

Pyogenic granulomas (PGs) in the oral cavity present as an inflammatory hyperplasia usually caused by trauma, hormonal imbalance, chronic irritation, or as the response to a wide variety of drugs. PGs with atypical presentation and behavior may clinically mimic malignant tumors. Thus, histological examination is required to rule out cancer development. Lesions in the oral cavity have been described to be either an isolated entity or present in multiple forms and with multiple recurrences. Conservative surgical excision is the standard choice of treatment in almost every scenario. However, the severity of the lesions and the affected sites often challenge surgical treatment. In this report, we describe the clinical scenario of a recurrent PG, where surgical excision of the lesion was questioned. As an alternative, we describe a noninvasive approach with lesional steroid injections.

Benign and Malignant Tumors of Oral Cavity

2008 ◽  
pp. 206-206
Author(s):  
KMK Masthan ◽  
M Kumar ◽  
R Sarangarajan ◽  
N Babu
Keyword(s):  
Oral Cavity ◽  
Malignant Tumors

scholarly journals Exosomes: Salivary Biomarkers?

2020 ◽  
Vol 19 (3) ◽  
pp. 667-672 ◽  
Author(s):  
Zeeshan Qamar ◽  
Fayez Hussain Niazi ◽  
Syed Bilal Tanveer ◽  
Tayyaba Zeeshan
Keyword(s):  
Oral Cavity ◽  
Body Fluids ◽  
Recent Time ◽  
Cellular Communication ◽  
Physiological Status ◽  
Cell Of Origin ◽  
Salivary Biomarkers ◽  
Diagnostic Potential ◽  
Immune Biomarkers

Saliva is a bio-fluid considered similar to blood in that it contains various DNAs, RNAs and proteins. Therefore, it is a fluid with diagnostic potential. In recent time, exosomes are emerging as nano-vesicles which enhance intra-cellular communication. Exosomal content, which is dependent on the cell of origin, reflects physiological status of cells. Exosomes have potentials for use as biomarkers for variant diseases, based on their stability and availability in various body fluids. Current studies have proposed the role of exosomes as immuno-modulators in the etiology of auto-immune diseases and cancers. The present study focused on the role of exosomes as biomarkers and their therapeutic potentials in particular diseases related to the oral cavity. Keywords: Exosomes, Auto-immune, Biomarkers, Saliva, Diagnosis

An observational study of benign oral lesions in central India

2017 ◽  
Vol 3 (4) ◽  
pp. 816
Author(s):  
Prashant N. Keche ◽  
Nishikant P. Gadpayle ◽  
Surendra H. Gawarle ◽  
Gaurav A. Chamania
Keyword(s):  
Oral Cavity ◽  
Malignant Tumors ◽  
Early Stage ◽  
Minor Salivary Gland ◽  
Salivary Gland Tumor ◽  
Oral Lesions ◽  
Age Group ◽  
Cross Sectional ◽  
Male Predominance ◽  
Malignant Lesions

<p class="abstract"><strong>Background:</strong> <span lang="EN-IN">The oral mucosa serves as a protective barrier against trauma, pathogens and carcinogenic agents. It can be affected by a wide variety of lesions and conditions, some of which are harmless while others may have serious complications. The appearance of benign oral soft tissue masses can occasionally resemble malignant tumors. </span></p><p class="abstract"><strong>Methods:</strong> <span lang="EN-IN">Present study is an observational and cross sectional study under taken in the Department of ENT in Shri Vasant Rao Naik Government Medical College, Yavatmal. All cases of benign oral lesions were included in the study and following cases were excluded: malignant oral lesions, immunocompromised state and benign Oral lesions due to systemic diseases.  </span></p><p class="abstract"><strong>Results:</strong> <span lang="EN-IN">Present study included 235 lesions of oral cavity which were clinically or histo-pathologically found to be benign in nature.<strong> </strong>Benign oral lesions were more commonly found in males with (70.2%) than females (29.8%), and M:F ratio was 2.3:1. most common benign oral lesions were found to be Oral Sub Mucus Fibrosis (26.8%) followed by Apthous ulcers (20.4%), Leukoplakia (18.3%) and Mucocele (17.1%). Least common benign oral lesions were found to be Minor Salivary Gland Tumor (MSGT) (1.7%) followed by Squamous Papilloma (2.1%), Ranula (2.1%) and Hemangioma (2.1). There was a male predominance in oral sub mucus fibrosis with M:F ratio of 9.5:1 followed by Leukoplakia with M:F ratio of 4.4:1. OSMF was found most commonly in 21-30 years age group with (57.1%). Followed by 11-20 years with (20.6%). No cases were found in ≤10 years, 51-60 and &gt;60 years age group. </span></p><p class="abstract"><strong>Conclusions:</strong> <span lang="EN-IN">Most of the benign oral lesions have a predilection to transform into malignant lesions therefore imperative to diagnose the pre malignant lesions of oral cavity in an early stage where appropriate treatment can be given.</span></p>

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