Diagnostic accuracy of urinary indices to detect mild dehydration in young men following acute riboflavin, Vitamin C or beetroot supplementation

In healthy young men (age, 20–22 years), we tested the role of prostanoids produced by the COX (cyclo-oxygenase) pathway in cutaneous vasodilatation evoked in the finger by ACh (acetylcholine). To this end, changes in cutaneous RCF (red cell flux), recorded by the laser Doppler technique, evoked by a series of iontophoretic pulses of ACh were tested before and after oral aspirin (600 mg). Increases in RCF produced by successive pulses of ACh up to a mean change of 125.5±11.8 PU (perfusion units) were potentiated 30 min after aspirin (160.0±12.4 PU; P<0.05). By contrast, aspirin had no effect on increases in RCF evoked by iontophoretic application of the NO (nitric oxide) donor and endothelium-independent dilator sodium nitroprusside (mean increases in RCF were 73.8±9.8 PU before and 79.1±12.2 PU after aspirin). The ACh-evoked increases in RCF were also potentiated 3 h after oral administration of the antioxidant vitamin C (1000 mg; 139.1±15.4 PU before and 170.5±13.5 PU after vitamin C; P<0.05). We propose that, in healthy young men, cutaneous vasodilatation evoked in the finger by the endothelium-dependent dilator ACh is limited by constrictor products of the COX pathway, including PGH2 (prostaglandin H2), TXA2 (thromboxane A2) and/or superoxide anions. This effect of the COX products may be an early marker of the increased risk of cardiovascular disease in men compared with women.

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Perbandingan Pemberian Tablet Fe dan Vitamin C dengan Tablet Fe dan Vitamin A terhadap Peningkatan Kadar Hemoglobin pada Mahasiswi Kebidanan

Jurnal Penelitian Kesehatan SUARA FORIKES (Journal of Health Research Forikes Voice) ◽

10.33846/sf11101 ◽

2020 ◽

Vol 11 (1) ◽

pp. 1

Author(s):

Halida Thamrin ◽

Suchi Avnalurini Sharief

Keyword(s):

Vitamin A ◽

Vitamin C ◽

Young Women ◽

Young Men ◽

Sampling Technique ◽

T Test ◽

Mean Difference ◽

The Body ◽

Purposive Sampling ◽

Vit C

Young women have a high risk of anemia, this is due to the loss of iron during menstruation. Young women have a higher risk to experience of anemia than young men because young women experience menstruation each month and desire to diet so that the body is deficient in essential nutrients such as iron. The purpose of this research is to know the comparison of tablet Fe and Vit C with tablet Fe and Vit A to increase the level of hemoglobin on the student of Midwifery School of Universitas Muslim Indonesia. The population in the study was all students of Midwifery School of Universitas Muslim Indonesia, with population size of 131 students. The samples were taken with purposive sampling technique based on certain criteria, with sample size of 32 students. The results of study showed that there was an increase in hemoglobin levels in the group of tablet Fe and vitamin C and the group of tablet Fe and vitamin A. Statistical test results using the T-Test obtained mean difference-1.950, p = 0.000 meaning there is a meaningful difference to the increase in hemoglobin level. Keywords: young men; hemoglobin; tablet Fe; vitamin C, vitamin A ABSTRAK Remaja putri memiliki risiko tinggi mengalami anemia, hal ini disebabkan hilangnya zat besi saat menstruasi. Remaja putri mempunyai risiko lebih tinggi terkena anemia dibandingkan remaja putra karena remaja putri mengalami menstruasi tiap bulannya dan keinginan untuk diet sehingga tubuh kekurangan zat gizi penting seperti zat besi. Tujuan penelitian ini untuk mengetahui Perbandingan Pemberian Tablet Fe dan Vit C dengan Tablet Fe dan Vit A terhadap Peningkatan kadar Hb pada Mahasiswi Prodi DIII Kebidanan Universitas Muslim Indonesia. Jenis penelitian ini adalah penelitian Quasi Experimental dengan pendekatan post test only design untuk Mengetahui Perbandingan Pemberian Tablet Fe dan Vit C dengan Tablet Fe dan Vit A terhadap Peningkatan kadar Hb pada Mahasiswi Prodi DIII Kebidanan Universitas Muslim Indonesia. Adapun populasi pada penelitian adalah seluruh mahasiswi prodi DIII Kebidanan, dengan ukuran populasi 131 mahasiswa. Adapun sampel diambil dengan teknik purposive sampling berdasarkan kriteria tertentu, dengan ukuran sampel 32 mahasiswa. Hasil penelitian menunjukkan bahwa ada peningkatan kadar hemoglobin pada kelompok tablet Fe dan vitamin C dan kelompok tablet Fe dan vitamin A. Hasil uji statistik menggunakan uji t-test diperoleh mean difference -1,950, p = 0,000 yang artinya ada perbedaan yang bermakna terhadap peningkatan kadar hemoglobin. Kata kunci: remaja putri; hemoglobin; tablet Fe; vitamin C; vitamin A

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Vitamin C supplementation (1000 mg/d) increased physical activity and reduced cold symptoms in young men with adequate‐to‐low vitamin C status (828.3)

The FASEB Journal ◽

10.1096/fasebj.28.1_supplement.828.3 ◽

2014 ◽

Vol 28 (S1) ◽

Author(s):

Carol Johnston ◽

Gillean Barkyoumb ◽

Sara Schumacher

Keyword(s):

Physical Activity ◽

Vitamin C ◽

Young Men ◽

Vitamin C Supplementation

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Rapid screening of critically ill patients for low plasma vitamin C concentrations using a point-of-care oxidation–reduction potential measurement

Intensive Care Medicine Experimental ◽

10.1186/s40635-021-00403-w ◽

2021 ◽

Vol 9 (1) ◽

Author(s):

Sander Rozemeijer ◽

Bob Smit ◽

Paul W. G. Elbers ◽

Armand R. J. Girbes ◽

Heleen M. Oudemans-van Straaten ◽

...

Keyword(s):

Vitamin C ◽

Diagnostic Accuracy ◽

Critically Ill ◽

Critically Ill Patients ◽

Reduction Potential ◽

Point Of Care ◽

Plasma Vitamin ◽

Vitamin C Deficiency ◽

Oxidation Reduction ◽

Oxidation Reduction Potential

Abstract Background Hypovitaminosis C and vitamin C deficiency are common in critically ill patients and associated with organ dysfunction. Low vitamin C status often goes unnoticed because determination is challenging. The static oxidation reduction potential (sORP) reflects the amount of oxidative stress in the blood and is a potential suitable surrogate marker for vitamin C. sORP can be measured rapidly using the RedoxSYS system, a point-of-care device. This study aims to validate a model that estimates plasma vitamin C concentration and to determine the diagnostic accuracy of sORP to discriminate between decreased and higher plasma vitamin C concentrations. Methods Plasma vitamin C concentrations and sORP were measured in a mixed intensive care (IC) population. Our model estimating vitamin C from sORP was validated by assessing its accuracy in two datasets. Receiver operating characteristic (ROC) curves with areas under the curve (AUC) were constructed to show the diagnostic accuracy of sORP to identify and rule out hypovitaminosis C and vitamin C deficiency. Different cut-off values are provided. Results Plasma vitamin C concentration and sORP were measured in 117 samples in dataset 1 and 43 samples in dataset 2. Bias and precision (SD) were 1.3 ± 10.0 µmol/L and 3.9 ± 10.1 µmol/L in dataset 1 and 2, respectively. In patients with low plasma vitamin C concentrations, bias and precision were − 2.6 ± 5.1 µmol/L and − 1.1 ± 5.4 µmol in dataset 1 (n = 40) and 2 (n = 20), respectively. Optimal sORP cut-off values to differentiate hypovitaminosis C and vitamin C deficiency from higher plasma concentrations were found at 114.6 mV (AUC 0.91) and 124.7 mV (AUC 0.93), respectively. Conclusion sORP accurately estimates low plasma vitamin C concentrations and can be used to screen for hypovitaminosis C and vitamin C deficiency in critically ill patients. A validated model and multiple sORP cut-off values are presented for subgroup analysis in clinical trials or usage in clinical practice.

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