Gut microbiota composition change in type 1 diabetes brazilian patients

2021 ◽  
Vol 46 ◽  
pp. S657
Author(s):  
D.C. Fonseca ◽  
I.M.G. da Rocha ◽  
L. Callado ◽  
D.P.D.S. Pinelli ◽  
B.D. Balmant ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Gut Microbiota ◽  
Microbiota Composition ◽  
Composition Change ◽  
Gut Microbiota Composition

scholarly journals Can the FUT2 Non-secretor Phenotype Associated With Gut Microbiota Increase the Children Susceptibility for Type 1 Diabetes? A Mini Review

2020 ◽  
Vol 7 ◽  
Author(s):  
Ottavia Giampaoli ◽  
Giorgia Conta ◽  
Riccardo Calvani ◽  
Alfredo Miccheli
Keyword(s):  
Type 1 Diabetes ◽  
Gut Microbiota ◽  
Clinical Manifestations ◽  
Short Chain Fatty Acids ◽  
Chronic Inflammatory Disease ◽  
Host Susceptibility ◽  
Microbiota Composition ◽  
Formula Milk ◽  
Gut Microbiota Composition

The global toll of type 1 diabetes (T1D) has steadily increased over the last decades. It is now widely acknowledged that T1D pathophysiology is more complex than expected. Indeed, a multifaceted interplay between genetic, metabolic, inflammatory and environmental factors exists that leads to heterogeneous clinical manifestations across individuals. Children with non-secretor phenotype and those affected by T1D share low abundance of bifidobacteria, low content of short-chain fatty acids, intestinal phosphatase alkaline and a high incidence of inflammatory bowel diseases. In this context, host-gut microbiota dyad may represent a relevant contributor to T1D development and progression due to its crucial role in shaping host immunity and susceptibility to autoimmune conditions. The FUT2 gene is responsible for the composition and functional properties of glycans in mucosal tissues and bodily secretions, including human milk. FUT2 polymorphisms may profoundly influence gut microbiota composition and host susceptibility to viral infections and chronic inflammatory disease. In this minireview, the possible interplay between mothers' phenotype, host FUT2 genetic background and gut microbiota composition will be discussed in perspective of the T1D onset. The study of FUT2-gut microbiota interaction may add a new piece on the puzzling T1D etiology and unveil novel targets of intervention to contrast T1D development and progression. Dietary interventions, including the intake of α-(1, 2)-fucosyl oligosaccharides in formula milk and the use of specific prebiotics and probiotics, could be hypothesized.

scholarly journals Aberrant gut microbiota composition at the onset of type 1 diabetes in young children

Diabetologia ◽  
2014 ◽  
Vol 57 (8) ◽  
pp. 1569-1577 ◽  
Author(s):  
Marcus C. de Goffau ◽  
Susana Fuentes ◽  
Bartholomeus van den Bogert ◽  
Hanna Honkanen ◽  
Willem M. de Vos ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Young Children ◽  
Gut Microbiota ◽  
Microbiota Composition ◽  
Gut Microbiota Composition

Arginine metabolism and gut microbiota changes in pediatric patients with type 1 diabetes

2020 ◽  
Author(s):  
Elena Aghajanova ◽  
Arthur Melkonyan ◽  
Nina Alchujyan ◽  
Bayburdyan Gayane ◽  
Margarita Hovhannisyan ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Gut Microbiota ◽  
Pediatric Patients ◽  
Arginine Metabolism

1290-P: Gut Microbiota in New-Onset Pediatric Patients with Type 1 Diabetes: Machine Learning Algorithms to Classify Microorganisms Disease-Linked

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 1290-P
Author(s):  
GIUSEPPE D’ANNUNZIO ◽  
ROBERTO BIASSONI ◽  
MARGHERITA SQUILLARIO ◽  
ELISABETTA UGOLOTTI ◽  
ANNALISA BARLA ◽  
...  
Keyword(s):  
Machine Learning ◽  
Type 1 Diabetes ◽  
Gut Microbiota ◽  
Pediatric Patients ◽  
Learning Algorithms ◽  
Machine Learning Algorithms ◽  
New Onset
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