Osteosarcopenic obesity; ultrasonographically defined and strongly related with frailty

Background:Rheumatoid arthritis (RA) is a complex inflammatory disease that modifies body composition. Using the dual-energy x-ray absorptiometry (DXA) in RA patients could be a method for body composition changes detection.Objectives:To study the body composition using DXA in patients with RA.Methods:The study involved 79 women with RA, median age 60 [55; 65] years. The bone mineral density (BMD) was measured by dual-energy x-ray absorptiometry using «Discovery A» (Hologic, USA). Assessment of body composition was carried out, using the program «Whole body». Sarcopenia (SP) was diagnosed as a decrease in appendicular mass index (AMI) <6.0 kg/m2. Osteoporosis (OP) was diagnosed as a decrease in T-score <-2.5 SD. Osteosarcopenia was determined when T-score was <-1.0 SD, AMI was <6.0 kg/m2, osteosarcopenic obesity - T-score was <-1.0 SD, AMI was <6.0 kg/m2and total fat was >35%.Results:The mean duration of RA was 9 [3; 11] years. The mean body mass index (BMI) was 27.6±4.8 kg/m2. Disease activity score in 28 joints-erythrocyte sedimentation rate was 4.5±1.3 points for the group. 39 (49.3%) patients used oral glucocorticoids continuously. Appendicular muscle mass and AMI were on average 17.8±3.0 kg and 6.8±1.0 kg/m2, respectively. AMI <6 kg/m2was detected in 20 (25.3%) patients. 56 (70.9%) women with RA had total fat > 35%, while only 22 (27.8%) of women with RA had obesity according to BMI (BMI >30 kg/m2). Isolated OP was found in 13 (16.5%), osteosarcopenia in 7 (8.9%) and osteosarcopenic obesity in 13 (16.5%) patients RA. No cases with isolated sarcopenia or sarcopenic obesity were detected. Only 3 (3.8%) patients did not have appendicular muscle mass, AMI and BMD decrease and overfat or obesity.Conclusion:About 97% women with RA had abnormal body composition phenotype: 16,5% - OP, 8.9% -osteosarcopenia, 16,5% - osteosarcopenic obesity and 54,4% - overfat.Disclosure of Interests:None declared

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Effect of 12-weeks elastic band resistance training on MyomiRs and osteoporosis markers in elderly women with Osteosarcopenic obesity: a randomized controlled trial

BMC Geriatrics ◽

10.1186/s12877-021-02374-9 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Ebrahim Banitalebi ◽

Majid Mardaniyan Ghahfarrokhi ◽

Mortaza Dehghan

Keyword(s):

Vitamin D ◽

Randomized Controlled Trial ◽

Type I Collagen ◽

Assessment Tool ◽

Elderly Women ◽

Controlled Trial ◽

Type I ◽

Elastic Band ◽

Randomized Controlled ◽

Osteosarcopenic Obesity

Abstract Background Interorgan communication networks established during exercise in several different tissues can be mediated by several exercise-induced factors. Therefore, the present study aimed to investigate the effects of resistance-type training using elastic band-induced changes of myomiRs (i.e., miR-206 and miR-133), vitamin D, CTX-I, ALP, and FRAX® score in elderly women with osteosarcopenic obesity (OSO). Methods In this randomized controlled trial, 63 women (aged 65–80 years) with Osteosarcopenic Obesity were recruited and assessed, using a dual-energy X-ray absorptiometry instrument. The resistance-type training via elastic bands was further designed three times per week for 12-weeks. The main outcomes were Fracture Risk Assessment Tool score, bone mineral content, bone mineral density, vitamin D, alkaline phosphatase, C-terminal telopeptides of type I collagen, expression of miR-206 and miR-133. Results There was no significant difference between the study groups in terms of the Fracture Risk Assessment Tool score (p = 0.067), vitamin D (p = 0.566), alkaline phosphatase (p = 0.334), C-terminal telopeptides of type I collagen (p = 0.067), microR-133 (p = 0.093) and miR-206 (p = 0.723). Conclusion Overall, the results of this study illustrated 12-weeks of elastic band resistance training causes a slight and insignificant improvement in osteoporosis markers in women affected with Osteosarcopenic Obesity. Trial registration Randomized controlled trial (RCT) (Iranian Registry of Clinical Trials, trial registration number: IRCT20180627040260N1. Date of registration: 27/11/2018.

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Osteosarcopenic Obesity

Osteosarcopenia: Bone, Muscle and Fat Interactions ◽

10.1007/978-3-030-25890-0_14 ◽

2019 ◽

pp. 323-343

Author(s):

David Scott

Keyword(s):

Osteosarcopenic Obesity

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Healthy overweight/obese youth: early osteosarcopenic obesity features

European Journal of Clinical Investigation ◽

10.1111/eci.12659 ◽

2016 ◽

Vol 46 (9) ◽

pp. 767-778 ◽

Cited By ~ 25

Author(s):

Charikleia Stefanaki ◽

Melpomeni Peppa ◽

Dario Boschiero ◽

George P. Chrousos

Keyword(s):

Obese Youth ◽

Osteosarcopenic Obesity

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[Research Notes] Osteosarcopenic Obesity in Elderly: The Cascade of Bone, Muscle, and Fat in Inflammatory Process

Culinary Science & Hospitality Research ◽

10.20878/cshr.2017.23.6.019 ◽

2017 ◽

Vol 23 (6) ◽

pp. 173-183 ◽

Cited By ~ 1

Author(s):

Yang Du ◽

노재경 ◽

오초롱

Keyword(s):

Inflammatory Process ◽

Osteosarcopenic Obesity

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Association of Dietary Diversity with Health-related Quality of Life and Osteosarcopenic Obesity in Korean Female Adults (P18-059-19)

Current Developments in Nutrition ◽

10.1093/cdn/nzz039.p18-059-19 ◽

2019 ◽

Vol 3 (Supplement_1) ◽

Cited By ~ 1

Author(s):

Yun-Jung Bae

Keyword(s):

Quality Of Life ◽

Dietary Diversity ◽

Age Group ◽

Health Related Quality ◽

Dietary Diversity Score ◽

Significant Difference ◽

Related Quality ◽

Health Related ◽

Osteosarcopenic Obesity

Abstract Objectives This study was conducted to evaluate the association of dietary diversity score with health-related quality of life and osteosarcopenic obesity in female aged 50 or older using data from the 2008∼2010 National Health and Nutrition Examination Survey (KNHANES). Methods In this cross-sectional study, a total of 4276 subjects (50∼64y: n = 2279, ≥65y: n = 1997) were classified according to dietary diversity score (DDS) (≥3 DDS, <3 DDS) using 24 h dietary recalls method. Body composition was evaluated using dual-energy X-ray absorptiometry (DXA) and health-related quality of life was assessed using EQ-5D (EuroQol five-dimension) index. Analysis was conducted by age-stratified groups: 50∼64 (≥3 DDS = 2070, <3 DDS = 209) and 65 (≥3 DDS = 1534, <3 DDS = 463) yrs or older. Results The ≥3 DDS group had a larger proportion of subjects who were highly educated compared to <3 DDS group (P < 0.001). In the 65 yrs or older age group, age-adjusted means of EQ-5D index of ≥3 DDS group and <3 DDS group were 0.84 and 0.74, respectively and there was significant difference (P < 0.0001). However, in the 50∼64 yrs age group, no difference was observed in EQ-5D index according to the dietary diversity. The ≥3 DDS group had a larger proportion of subjects who had no osteosarcopenic obesity compared to <3 DDS group (P < 0.05). Conclusions These results suggest that the dietary diversity may be associated with a lower health-related quality of life and osteosarcopenic obesity in Korean female aged 50 years or older. Funding Sources This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP; Ministry of Science, ICT & Future Planning) (No. 2017R1C1B5017636).

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