[Research Notes] Osteosarcopenic Obesity in Elderly: The Cascade of Bone, Muscle, and Fat in Inflammatory Process

Pathological vaginal discharge is one of the most common complaints in women of all ages. Today, gynecologists are increasingly faced with a problem when, in the absence of laboratory confirmation of vulvovaginal candidiasis, bacterial vaginosis and STIs, women complain of discomfort caused by vaginal secretions. Causes of pathological vaginal discharge can be infectious and non-infectious processes and their combinations. The article analyzes the causes of the difficulties of diagnosing the of pathological vaginal discharge ethiology, demonstrates how the application of adequate volume of modern laboratory diagnostic methods in combination with understanding the multifaceted components of the inflammatory process plays crucial role in finding out the etiology of pathological vaginal secretions and the choice of optimal therapeutic tactics. Key words: pathological vaginal dischurge, vaginal microbiota, vulvovaginal candidiasis, bacterial vaginosis, aerobic vaginitis, cytolytic vaginosis.

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Determination of clinical efficiency of deproteinized dialysate from blood of milk-fed calves after endoprosthetics in patients with ventral hernias

I P Pavlov Russian Medical Biological Herald ◽

10.23888/pavlovj2020283323-333 ◽

2020 ◽

Vol 28 (3) ◽

pp. 323-333

Author(s):

Sergej V. Ivanov ◽

Ilya S. Ivanov ◽

Evgenij G. Obyedkov ◽

Liliya P. Popova

Keyword(s):

Abdominal Wall ◽

Inflammatory Reaction ◽

Inflammatory Process ◽

Anterior Abdominal Wall ◽

Dynamic Change ◽

Main Group ◽

Control Group ◽

Surgical Department ◽

Regeneration Stage

Aim. To study the influence of deproteinized dialysate from blood of milk-fed calves on the type of exudative discharge and dynamics of inflammatory reaction after hernia repair with plastics of the anterior abdominal wall with hernioendoprosthesis of polypropylene. Materials and Methods. The study involved 59 patients being on stationary treatment in the surgical department of Kursk Regional Clinical Hospital. Patients were hospitalized for the herniation of small or medium dimension. The patients were divided to two groups: the main (n=30) and control (n=29) groups. After endoprosthetics, the patients of the control group were given complex conservative treatment. The patients of the main group, besides standard treatment, were administered deproteinized dialysate from blood of milk-fed calves intravenously in drips 10 ml + 200 ml of 0.9% sodium chloride solution within 7 days. For cytological examination and determination of the type of cytograms, the traumatic discharge was collected and analyzed using the method of M.F. Kamaev and M.A. Palthsev. Results. Cytomorphometric examination was conducted on the third, fifth and seventh day after endoprosthetics with the aim of studying dynamic changes. Determination of cell composition and also of its changes characteristic of each studied period, was necessary for obtaining further information characterizing inflammatory process in the region of placement of the endoprosthesis. After endoprosthetics in patients who were administered hemodialysate, the inflammatory reaction was less pronounced than in patients who did not receive the preparation. This was associated with a more dynamic change of stages of the inflammatory process. In patients of the main group who received deproteinized dialysate, regenerative type of inflammation first appeared on the fifth day and made 6.9%; by the seventh day the share of patients with the regenerative type rose to 17.5%, while in the patients of the control group no regeneration stage was observed in both periods. Conclusion. Analysis of the efficiency of influence of hemodialysate on the inflammatory reaction in plastics of the anterior abdominal wall with polypropylene endoprosthesis evidences faster course of all stages of inflammation and reduction of its intensity by 10%.

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DIFFICULTIES IN PRIMARY DETECTION AND DIFFERENTIAL DIAGNOSIS OF THE INFLAMMATORY PROCESS AND DYSFUNCTION OF THE LOWER URINARY TRACT IN CHILDREN

PEDIATRIA Journal named after G N SPERANSKY ◽

10.24110/0031-403x-2020-99-5-92-97 ◽

2020 ◽

Vol 99 (5) ◽

pp. 92-97

Author(s):

V.D. Konoplev ◽

◽

N.B. Guseva ◽

E.K. Zabotina ◽

M.V. Runkova ◽

...

Keyword(s):

Differential Diagnosis ◽

Urinary Tract ◽

Lower Urinary Tract ◽

Inflammatory Process ◽

Lower Urinary

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Microbial Factor as a Participant of the Infectious Inflammatory Process in the Oral Cavity Pathology

Ukraïnsʹkij žurnal medicini bìologìï ta sportu ◽

10.26693/jmbs02.03.012 ◽

2017 ◽

Vol 2 (3) ◽

pp. 12-15 ◽

Cited By ~ 1

Author(s):

E.V. Kotsar ◽

◽

O.I. Radchenko ◽

O.V. Golubka ◽

A.V. Masalova ◽

...

Keyword(s):

Oral Cavity ◽

Inflammatory Process

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Relationship Between Gamma-glutamyl Transpeptidase Activity and Inflammatory Response in Lichen Planus

Revista de Chimie ◽

10.37358/rc.18.3.6189 ◽

2018 ◽

Vol 69 (3) ◽

pp. 739-743 ◽

Cited By ~ 3

Author(s):

Madalina Irina Mitran ◽

Ilinca Nicolae ◽

Corina Daniela Ene ◽

Cristina Iulia Mitran ◽

Clara Matei ◽

...

Keyword(s):

Inflammatory Response ◽

Lichen Planus ◽

Inflammatory Process ◽

Molecular Mechanisms ◽

Functional Adaptation ◽

Physical Factors ◽

Inflammatory Disorder ◽

Gamma Glutamyl Transpeptidase ◽

Gamma Glutamyl ◽

Glutamyl Transpeptidase

Chemicals used in the manufacture of synthetic fibers have been associated with undesirable side effects such as itching or skin lesions and it seems that they are involved in the induction of pathological processes such as oxidative stress and inflammation. Lichen planus (LP) can be regarded as an inflammatory disorder, chemical and physical factors playing an important role in the perpetuation of the inflammatory process. Gamma-glutamyl transpeptidase (GGT) plays an important role in the preservation of skin architecture and modulation of skin inflammation. In this study, we found that GGT activity is increased in LP patients with mild inflammation, whilst GGT is inactivated under conditions of severe inflammation. Therefore, GGT is involved in the inflammatory process, but there is no a positive correlation between its activity and the intensity of the inflammatory response. This functional adaptation of the enzyme may be due to down-regulation of its synthesis under free radical overload conditions. Understanding the molecular mechanisms involved in the modulation of intracellular redox homeostasis is an important step in the pharmacological management of patients with LP.

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Towards Better Drug Repositioning: Targeted Immunoinflammatory Therapy for Diabetic Nephropathy

Current Medicinal Chemistry ◽

10.2174/0929867326666191108160643 ◽

2019 ◽

Vol 26 ◽

Author(s):

Qin zhang ◽

Ming Yang ◽

Ying Xiao ◽

Yachun Han ◽

Shikun Yang ◽

...

Keyword(s):

Diabetes Mellitus ◽

Diabetic Nephropathy ◽

Inflammatory Process ◽

Drug Repositioning ◽

Microvascular Complications ◽

Pathogenic Factor ◽

Progressive Decline ◽

Functional Changes ◽

Sequence Of Events ◽

Novel Treatment

: Diabetic nephropathy (DN) is one of the most common and important microvascular complications of diabetes mellitus (DM). The main clinical features of DN are proteinuria and a progressive decline in renal function , which are associated with structural and functional changes in the kidney. The pathogenesis of DN is multifactorial, including genetic, metabolic and haemodynamic factors, which can trigger a sequence of events. Controlling metabolic risks such as hyperglycaemia, hypertension and dyslipidaemia is not enough to slow the progression of DN. Recent studies have emphasized immunoinflammation as a critical pathogenic factor in the progression of DN. Therefore, targeting inflammation is considered a potential and novel treatment strategy for DN. In this review, we will briefly introduce the inflammatory process of DN and discuss the anti-inflammatory effects of antidiabetic drugs when treating DN.

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Gelatin and Glycerine-Based Bioadhesive Vaginal Hydrogel

Current Drug Delivery ◽

10.2174/1567201817666200129130031 ◽

2020 ◽

Vol 17 (4) ◽

pp. 303-311

Author(s):

Roberta Cassano ◽

Federica Curcio ◽

Delia Mandracchia ◽

Adriana Trapani ◽

Sonia Trombino

Keyword(s):

Differential Scanning Calorimetry ◽

Inflammatory Process ◽

Vaginal Mucosa ◽

Vaginal Infection ◽

Scanning Calorimetry ◽

Time Intervals ◽

Site Specific ◽

Release Studies ◽

Hiv Seropositive

Aim: The work’s aim was the preparation and characterization of a hydrogel based on gelatin and glycerine, useful for site-specific release of benzydamine, an anti-inflammatory drug, able to attenuate the inflammatory process typical of the vaginal infection. Objective: The obtained hydrogel has been characterized by Electronic Scanning Microscopy (SEM) and Differential Scanning Calorimetry (DSC). In addition, due to the precursor properties, the hydrogel exhibits a relevant mucoadhesive activity. Methods: The swelling degree was evaluated at two different pHs and at defined time intervals. In particular, phosphate buffers were used at pH 6.6, in order to mimic the typical conditions of infectious diseases at the vaginal level, particularly for HIV-seropositive pregnant women, and pH 4.6, to simulate the physiological environment. Results: The obtained results revealed that the hydrogel swells up well at both pHs. Conclusion: Release studies conducted at both pathological and physiological pHs have shown that benzydamine is released at the level of the vaginal mucosa in a slow and gradual manner. These data support the hypothesis of the hydrogel use for the site-specific release of benzydamine in the vaginal mucosa.

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