Effects of inorganic nitrate and vitamin C co-supplementation on blood pressure and vascular function in younger and older healthy adults: A randomised double-blind crossover trial

2020 ◽  
Vol 39 (3) ◽  
pp. 708-717 ◽  
Author(s):  
Ammar W. Ashor ◽  
Oliver M. Shannon ◽  
Anke-Dorothee Werner ◽  
Filippo Scialo ◽  
Cameron N. Gilliard ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Vitamin C ◽  
Vascular Function ◽  
Crossover Trial ◽  
Healthy Adults ◽  
Double Blind ◽  
Inorganic Nitrate

scholarly journals Cardiovascular Benefits of Vitamin C Supplementation Against Particulate Air Pollution in Healthy Adults: A Double-Blind Randomized Crossover Trial

2022 ◽  
Author(s):  
Jingyi Ren ◽  
Jufeng Liang ◽  
Jiaqi Wang ◽  
Bowen Yin ◽  
Fan Zhang ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Air Pollution ◽  
Young Adults ◽  
Vitamin C ◽  
Crossover Trial ◽  
Ambient Air ◽  
Dietary Vitamin ◽  
Double Blind ◽  
Tnf Α ◽  
Vitamin C Supplementation

Abstract Background: Accumulating evidence indicates that ambient air pollution exposure is associated with the adverse effects of cardiovascular diseases (CVDs). Evidence on the health benefits of vitamin C supplementation in highly polluted areas has not been evaluated. Objectives: We aims to evaluate whether dietary vitamin C supplementation can improve cardiovascular health linked to PM exposure. Methods: A randomized double-blind crossover trial was performed in 58 health young adults in Shijiazhuang, China in 2018. All subjects were randomly assigned to vitamin C supplementation or placebo group for a week alternating with a two-week washout period. We measured blood pressure (BP), blood lipid, biomarkers of oxidative and biomarkers of inflammation. Linear mixed-effect model was applied to evaluate the effect of vitamin C supplementation on health outcomes.Results: During the intervention periods, the average concentration of PM2.5 and PM10 was 164.91μg/m3 and 327.05μg/m3, respective. Vitamin C supplementation was significantly associated with decrease in several inflammatory indicators and blood pressure, including 19.47% in interleukin-6 (IL-6), 17.30% in tumor necrosis factor-a (TNF-α), 34.01% in C-reactive protein (CRP), 3.37% in systolic blood pressure (SBP) and 6.03% in pulse pressure (PP). Further, glutathione peroxidase (GSH-Px) was significantly increased by 7.15%. The effect of nutritional intervention on other indicators were beneficial, but there was no statistical difference. Gender-subgroup analysis showed that vitamin C supplementation significantly reduced SBP by 3.31%, PP by 4.94%, IL-6 by 20.97%, TNF-α by 27.85% and CRP by 38.5% in males, and significantly reduced SBP by 3.65%, PP by 8.12%, IL-6 by 17.35% and CRP by 29.15% in females. In contrast, vitamin C supplementation significantly increased APOB by 6.28% and GSH-Px by 14.47% in female participants only. Conclusion: This study indicates that vitamin C supplementation may protect cardiovascular system against particulate matter (PM) exposure among healthy young adults in China.Clinical trial registration information: Identifier: ChiCTR2100051371. Registered 19 October 2018, https://www.chictr.org.cn.

scholarly journals Effects of regular consumption of vitamin C-rich or polyphenol-rich apple juice on cardiometabolic markers in healthy adults: a randomized crossover trial

2014 ◽  
Vol 53 (8) ◽  
pp. 1645-1657 ◽  
Author(s):  
Alberto Soriano-Maldonado ◽  
María Hidalgo ◽  
Patricia Arteaga ◽  
Sonia de Pascual-Teresa ◽  
Esther Nova
Keyword(s):  
Vitamin C ◽  
Apple Juice ◽  
Crossover Trial ◽  
Healthy Adults ◽  
Randomized Crossover Trial ◽  
Regular Consumption ◽  
Cardiometabolic Markers

scholarly journals The effect of Sang-qi Granules on blood pressure and endothelial dysfunction in stageI or II hypertension: study protocol for a randomized double-blind double-simulation controlled trial

2019 ◽  
Author(s):  
Haoyue Shi ◽  
Deshuang Yang ◽  
Jiajun Qiao ◽  
Rui Sun ◽  
Ruihan Li ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Endothelial Dysfunction ◽  
Vascular Function ◽  
Short Form ◽  
Controlled Trial ◽  
Ankle Brachial Index ◽  
Vascular Endothelial ◽  
Double Blind ◽  
Endothelial Cell Function ◽  
Self Rating

Abstract Background Hypertension is an important worldwide public health challenge because of its high prevalence and concomitant risks of cardiovascular disease. It induces half of the coronary heart disease and approximately two-thirds of the cerebrovascular disease burdens. Vascular endothelial dysfunction plays important roles in the pathophysiology of essential hypertension. Sang-qi Granules (SQG), a Chinese herbal formula, is used to treat I or II hypertension. Several animal experimental studies have shown that SQG can lower blood pressure and myocardial fibrosis by suppressing inflammatory responses. However, there is no standard clinical trial to confirm this and whether SQG can improve endothelial cell function is unknown.Methods In this randomized, double-blind, double-simulation controlled trial, 300 patients with stage I or II hypertension will be recruited and randomly allocated in a 1:1:1 ratio to group A(treatment with SQG and placebo of Cozaar), group B (treatment with Cozaar and placebo of SQG), and group C (treatment with SQG and Cozaar). SQG (or its placebo) will be administrated twice a day at the doze of 10g each time, and 50mg Cozaar(or its placebo) will be administrated once in the morning. The primary endpoint is the drug efficiency of the each three groups. The secondary endpoints are the change of average systolic and diastolic blood pressure during the day and the night, the change of blood pressure drop rate at night, target organ damage assessment (heart rate variability, ankle-brachial index and pulse wave velocity), symptoms improvement assessment (hypertension symptom scale, TCM syndrome integral scale, Pittsburgh sleep quality index scale, Self-Rating Anxiety Scale, Self-Rating Depression Scale and the Short Form-36 Health Survey), blood lipids, serum indicators of vascular function (changes in serum ET-1, TXA2, NO, PGI2 values) and safety indicators.Discussion This study will provide clinical evidence for the efficacy and safety of SQG in the treatment of hypertension. Meanwhile, the possible mechanism of SQG for lowering blood pressure will be further explored by observing the protective effect of SQG on vascular endothelial function, as well as its effect on related clinical symptoms, risk factors and target organs of hypertension.

Effect of adding milk to black tea on vascular function in healthy men and women: a randomised controlled crossover trial

2018 ◽  
Vol 9 (12) ◽  
pp. 6307-6314 ◽  
Author(s):  
Adilah F. Ahmad ◽  
Lisa Rich ◽  
Henrietta Koch ◽  
Kevin D. Croft ◽  
Mario G. Ferruzzi ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Vascular Function ◽  
Crossover Trial ◽  
Black Tea ◽  
Tea Consumption ◽  
Short Term ◽  
Men And Women ◽  
Healthy Men ◽  
Randomised Controlled ◽  
P Addition

Addition of milk to black tea alters the acute/short-term benefical effect of regular black tea consumption on vascular function and blood pressure.

scholarly journals Nutritional composition of commercially-produced 100% orange juice reveals large variability in vascular health bioactive, hesperidin

2020 ◽  
Vol 79 (OCE2) ◽  
Author(s):  
Johan De Rycker ◽  
Carrie Ruxton ◽  
Markus Jungen ◽  
Ralf Schweiggert
Keyword(s):  
Blood Pressure ◽  
Vitamin C ◽  
Orange Juice ◽  
Vascular Function ◽  
Vascular Health ◽  
Citrus Fruits ◽  
Total Carotenoids ◽  
Bioactive Substances ◽  
Large Variability ◽  
Compliance Testing

AbstractIt is well-accepted that fruits contain a wide array of nutrients and bioactive substances which may contribute towards the prevention of chronic disease. Citrus fruits, as well as their juices, are recognised for their rich polyphenol content, specifically the flavanones; hesperidin, naringin and narirutin. Citrus fruits and juices are also rich in vitamin C and provide a source of folate, potassium and provitamin A.Randomised controlled trials have reported significant improvements to vascular function and blood pressure following consumption of 100% orange juice (OJ) with the effects potentially mediated through hesperidin and/or potassium (which has an EU claim for supporting normal blood pressure). Further clinical research may be facilitated by up-to-date information on the composition of OJ.By auditing more than 350 fruit processing companies worldwide, the non-profit organisation SGF International collects authentic OJ samples for regular compliance testing. Samples of unpasteurized OJ from the production line are removed by trained staff immediately post-extraction and frozen at -18°C within a few minutes. The samples are posted in this state to accredited laboratories where key nutrients and bioactives are tested. SGF's Database of Authentic Samples (2018) provides the following data (mg/litre) as sample size, mean, standard deviation, minimum, maximum for hesperidin (231, 520, 175, 109, 1160), L-ascorbic acid (615, 450, 98, 120, 721), potassium (1242, 1758, 204, 1197, 2340), total carotenoids (575, 7, 3, 2, 21) and pectins (1043, 334, 132, 19, 932).On average, there was more hesperidin in OJ than vitamin C, giving an estimated composition of 78 mg hesperidin and 67.5 mg vitamin C per 150 mL serving. Samples from Chinese producers had the greatest variability in hesperidin (109–1160 mg/L) while samples from Argentina, South Africa and Spain had the smallest variability. When OJ from not-from-concentrate (n = 62) and concentrate (n = 169) were compared, mean levels of hesperidin were significantly higher in the not-from-concentrate juice (576 mg/L [sd 228 mg/L] vs. 500 mg/L [sd 146 mg/L]; P = 0.016; Welch's t-test).Vascular benefits in humans have been detected at OJ intakes of 500 ml/day or hesperidin intakes of 290 mg/day (Morand et al. 2011). From a quality assurance perspective, the AIJN sets an acceptable range for hesperidin as 250–700mg/L. Raising the upper cut-off could increase the hesperidin content of commercially-available OJ with potential benefits for vascular health.Morand C et al. (2011) Am J Clin Nutr 93: 73–80.

scholarly journals Agave Inulin Supplementation Affects the Fecal Microbiota of Healthy Adults Participating in a Randomized, Double-Blind, Placebo-Controlled, Crossover Trial

2015 ◽  
Vol 145 (9) ◽  
pp. 2025-2032 ◽  
Author(s):  
Hannah D Holscher ◽  
Laura L Bauer ◽  
Vishnupriya Gourineni ◽  
Christine L Pelkman ◽  
George C Fahey ◽  
...  
Keyword(s):  
Crossover Trial ◽  
Fecal Microbiota ◽  
Healthy Adults ◽  
Double Blind ◽  
Double Blind Placebo
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