Cardiovascular Benefits of Vitamin C Supplementation Against Particulate Air Pollution in Healthy Adults: A Double-Blind Randomized Crossover Trial

Abstract Background: Accumulating evidence indicates that ambient air pollution exposure is associated with the adverse effects of cardiovascular diseases (CVDs). Evidence on the health benefits of vitamin C supplementation in highly polluted areas has not been evaluated. Objectives: We aims to evaluate whether dietary vitamin C supplementation can improve cardiovascular health linked to PM exposure. Methods: A randomized double-blind crossover trial was performed in 58 health young adults in Shijiazhuang, China in 2018. All subjects were randomly assigned to vitamin C supplementation or placebo group for a week alternating with a two-week washout period. We measured blood pressure (BP), blood lipid, biomarkers of oxidative and biomarkers of inflammation. Linear mixed-effect model was applied to evaluate the effect of vitamin C supplementation on health outcomes.Results: During the intervention periods, the average concentration of PM2.5 and PM10 was 164.91μg/m3 and 327.05μg/m3, respective. Vitamin C supplementation was significantly associated with decrease in several inflammatory indicators and blood pressure, including 19.47% in interleukin-6 (IL-6), 17.30% in tumor necrosis factor-a (TNF-α), 34.01% in C-reactive protein (CRP), 3.37% in systolic blood pressure (SBP) and 6.03% in pulse pressure (PP). Further, glutathione peroxidase (GSH-Px) was significantly increased by 7.15%. The effect of nutritional intervention on other indicators were beneficial, but there was no statistical difference. Gender-subgroup analysis showed that vitamin C supplementation significantly reduced SBP by 3.31%, PP by 4.94%, IL-6 by 20.97%, TNF-α by 27.85% and CRP by 38.5% in males, and significantly reduced SBP by 3.65%, PP by 8.12%, IL-6 by 17.35% and CRP by 29.15% in females. In contrast, vitamin C supplementation significantly increased APOB by 6.28% and GSH-Px by 14.47% in female participants only. Conclusion: This study indicates that vitamin C supplementation may protect cardiovascular system against particulate matter (PM) exposure among healthy young adults in China.Clinical trial registration information: Identifier: ChiCTR2100051371. Registered 19 October 2018, https://www.chictr.org.cn.

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Effects of inorganic nitrate and vitamin C co-supplementation on blood pressure and vascular function in younger and older healthy adults: A randomised double-blind crossover trial

Clinical Nutrition ◽

10.1016/j.clnu.2019.03.006 ◽

2020 ◽

Vol 39 (3) ◽

pp. 708-717 ◽

Cited By ~ 5

Author(s):

Ammar W. Ashor ◽

Oliver M. Shannon ◽

Anke-Dorothee Werner ◽

Filippo Scialo ◽

Cameron N. Gilliard ◽

...

Keyword(s):

Blood Pressure ◽

Vitamin C ◽

Vascular Function ◽

Crossover Trial ◽

Healthy Adults ◽

Double Blind ◽

Inorganic Nitrate

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Eczema, facial erythema, and seborrheic dermatitis symptoms among young adults in China in relation to ambient air pollution, climate, and home environment

Indoor Air ◽

10.1111/ina.12918 ◽

2021 ◽

Author(s):

Juan Wang ◽

Yinping Zhang ◽

Baizhan Li ◽

Zhuohui Zhao ◽

Chen Huang ◽

...

Keyword(s):

Air Pollution ◽

Young Adults ◽

Home Environment ◽

Seborrheic Dermatitis ◽

Ambient Air ◽

Ambient Air Pollution ◽

Facial Erythema

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Acute intake of quercetin from onion skin extract does not influence postprandial blood pressure and endothelial function in overweight-to-obese adults with hypertension: a randomized, double-blind, placebo-controlled, crossover trial

European Journal of Nutrition ◽

10.1007/s00394-016-1185-1 ◽

2016 ◽

Vol 56 (3) ◽

pp. 1347-1357 ◽

Cited By ~ 15

Author(s):

Verena Brüll ◽

Constanze Burak ◽

Birgit Stoffel-Wagner ◽

Siegfried Wolffram ◽

Georg Nickenig ◽

...

Keyword(s):

Blood Pressure ◽

Endothelial Function ◽

Crossover Trial ◽

Skin Extract ◽

Obese Adults ◽

Double Blind ◽

Double Blind Placebo ◽

Onion Skin ◽

Acute Intake

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Dietary nitrate improved exercise capacity in COPD but not blood pressure or pulmonary function: a 2 week, double-blind randomised, placebo-controlled crossover trial

International Journal of Food Sciences and Nutrition ◽

10.1080/09637486.2018.1492521 ◽

2018 ◽

Vol 70 (2) ◽

pp. 222-231 ◽

Cited By ~ 1

Author(s):

Conor P. Kerley ◽

Philip E. James ◽

Aisling McGowan ◽

John Faul ◽

Liam Cormican

Keyword(s):

Blood Pressure ◽

Pulmonary Function ◽

Exercise Capacity ◽

Crossover Trial ◽

Double Blind ◽

Dietary Nitrate

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Vitamin C supplementation improves blood pressure and oxidative stress after acute exercise in patients with poorly controlled type 2 diabetes mellitus: A randomized, placebo-controlled, cross-over study

The Chinese Journal of Physiology ◽

10.4103/cjp.cjp_95_20 ◽

2021 ◽

Vol 64 (1) ◽

pp. 16

Author(s):

Naruemon Leelayuwat ◽

Chongchira Boonthongkaew ◽

Terdthai Tong-Un ◽

Yupaporn Kanpetta ◽

Nisa Chaungchot ◽

...

Keyword(s):

Oxidative Stress ◽

Diabetes Mellitus ◽

Blood Pressure ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Vitamin C ◽

Acute Exercise ◽

Vitamin C Supplementation ◽

And Oxidative Stress

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Global association between ambient air pollution and blood pressure: A systematic review and meta-analysis

Environmental Pollution ◽

10.1016/j.envpol.2018.01.001 ◽

2018 ◽

Vol 235 ◽

pp. 576-588 ◽

Cited By ~ 101

Author(s):

Bo-Yi Yang ◽

Zhengmin Qian ◽

Steven W. Howard ◽

Michael G. Vaughn ◽

Shu-Jun Fan ◽

...

Keyword(s):

Systematic Review ◽

Blood Pressure ◽

Air Pollution ◽

Meta Analysis ◽

Ambient Air ◽

Ambient Air Pollution

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Short-term exposure to fine particulate air pollution and genome-wide DNA methylation: A randomized, double-blind, crossover trial

Environment International ◽

10.1016/j.envint.2018.07.041 ◽

2018 ◽

Vol 120 ◽

pp. 130-136 ◽

Cited By ~ 20

Author(s):

Huichu Li ◽

Renjie Chen ◽

Jing Cai ◽

Xiao Cui ◽

Nan Huang ◽

...

Keyword(s):

Dna Methylation ◽

Air Pollution ◽

Crossover Trial ◽

Short Term ◽

Double Blind ◽

Particulate Air Pollution ◽

Fine Particulate ◽

Genome Wide ◽

Short Term Exposure

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Short-term effects of air pollution on blood pressure

Scientific Reports ◽

10.1038/s41598-019-56413-y ◽

2019 ◽

Vol 9 (1) ◽

Cited By ~ 1

Author(s):

You-Jung Choi ◽

Sun-Hwa Kim ◽

Si-Hyuck Kang ◽

Sun-Young Kim ◽

Ok-Jin Kim ◽

...

Keyword(s):

Blood Pressure ◽

Air Pollution ◽

Air Pollutants ◽

Ambient Air ◽

Ambient Air Pollution ◽

Pathophysiological Mechanism ◽

Short Term ◽

Mortality And Morbidity ◽

Short Term Exposure ◽

Increased Risk

AbstractElevated blood pressure (BP) has been proposed as a possible pathophysiological mechanism linking exposure to ambient air pollution and the increased risk of cardiovascular mortality and morbidity. In this study, we investigated the hourly relationship between ambient air pollutants and BP. BP measurements were extracted from the electronic health record database of the Seoul National University Bundang Hospital from February 2015 to June 2017. A total of 98,577 individual BP measurements were matched to the hourly levels of air pollutants. A generalized additive model was constructed for hour lags of 0–8 of air pollutants adjusting for age, sex, meteorological variables, and time trend. Systolic BP was shown to be significantly lower at 2–4 hours and 3–5 hours after increased levels of SO2 and CO, respectively (0.24 mmHg and 0.26 mmHg for an interquartile range, respectively). In contrast, O3 and NO2 were associated with significantly increased systolic BP at 3–5 lag hours and at 0–2 lag hours, respectively. BP elevation in association with O3 and NO2 was shown to be significantly greater in hypertensive patients than normotensive subjects. Our findings suggest that short-term exposure to air pollution may be associated with elevated BP.

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Longitudinal changes in serum paraoxonase-1 activity throughout normal pregnancy

Clinical Chemistry and Laboratory Medicine (CCLM) ◽

10.1515/cclm.2006.156 ◽

2006 ◽

Vol 44 (7) ◽

Cited By ~ 10

Author(s):

Natàlia Ferré ◽

Jordi Camps ◽

Joan Fernández-Ballart ◽

Victoria Arija ◽

Michelle M. Murphy ◽

...

Keyword(s):

Vitamin C ◽

Normal Pregnancy ◽

Paraoxonase 1 ◽

Dietary Vitamin ◽

Pon1 Activity ◽

Longitudinal Changes ◽

Increased Risk ◽

Direct Association ◽

Vitamin C Supplementation ◽

Serum Paraoxonase

AbstractThe aim of this study was to investigate the longitudinal changes in serum paraoxonase-1 (PON1) activity from preconception throughout normal pregnancy and their relationships with maternal dietary vitamin C and E intake. The study was performed in 35 women (studied at preconception, at 8, 20 and 32weeks of pregnancy, and at labour). PON1 activity decreased significantly from 145.8 (109.8–198.8) U/L at preconception to 111.1 (85.3–179.9) U/L (p<0.01) at 32weeks and 100.4 (54.7–171.4) U/L (p<0.001) at labour. There was a direct association between vitamin C intake and PON1 at week 32 (p=0.018). We conclude that adequate vitamin C intake in pregnant women may merit consideration, since vitamin C supplementation has proved beneficial in the prevention of preeclampsia in women at increased risk of this condition.Clin Chem Lab Med 2006;44:880–2.

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