Poly(allylamine)/tripolyphosphate coacervates for encapsulation and long-term release of cetylpyridinium chloride

2021 ◽  
Vol 629 ◽  
pp. 127490
Author(s):  
Sabrina S. Alam ◽  
Carolina B. Mather ◽  
Youngwoo Seo ◽  
Yakov Lapitsky
Keyword(s):  
Cetylpyridinium Chloride

scholarly journals Comparison of Culture Methods for Isolation of Nontuberculous Mycobacteria from Surface Waters

2010 ◽  
Vol 76 (11) ◽  
pp. 3514-3520 ◽  
Author(s):  
Nicolas Radomski ◽  
Emmanuelle Cambau ◽  
Laurent Moulin ◽  
Sophie Haenn ◽  
R�gis Moilleron ◽  
...  
Keyword(s):  
Nontuberculous Mycobacteria ◽  
Cetylpyridinium Chloride ◽  
Competitive Growth ◽  
Culture Methods ◽  
Mycobacterium Chelonae ◽  
Water Testing ◽  
Antibiotic Cocktail ◽  
Rich Media ◽  
Human Infections

ABSTRACT The environment is the likely source of most nontuberculous mycobacteria (NTM) involved in human infections, especially pulmonary, skin, and soft tissue infections. In order to measure the prevalence of NTM in different aquatic ecosystems, we tried to standardize the culture methods used for surface water testing since many procedures have been described previously. Cultivation of mycobacteria requires long-term incubation in rich media and inactivation of rapidly growing microorganisms whose growth impedes observation of mycobacterial colonies. Consequently, the two criteria used for evaluation of the methods examined were (i) the rate of inhibition of nontarget microorganisms and (ii) the efficiency of recovery of mycobacteria. We compared the competitive growth of Mycobacterium chelonae and M. avium with nontarget microorganisms on rich Middlebrook 7H11-mycobactin medium after treatment by several chemical decontamination methods that included acids, bases, detergent, or cetylpyridinium chloride (CPC) with and without an antibiotic cocktail, either PANTA (40 U/ml polymyxin, 4 μg/ml amphotericin B, 16 μg/ml nalidixic acid, 4 μg/ml trimethoprim, and 4 μg/ml azlocillin) or PANTAV (PANTA plus 10 μg/ml vancomycin). Our results showed that treatment for 30 min with CPC (final concentration, 0.05%) of water concentrated by centrifugation, followed by culture on a rich medium supplemented with PANTA, significantly decreased the growth of nontarget microorganisms (the concentrations were 6.2 � 0.4 log10 CFU/liter on Middlebrook 7H11j medium and 4.2 � 0.2 log10 CFU/liter on Middlebrook 7H11j medium containing PANTA [P < 0.001]), while the effect of this procedure on NTM was not as great (the concentrations of M. chelonae on the two media were 7.0 � 0.0 log10 CFU/liter and 6.9 � 0.0 log10 CFU/liter, respectively, and the concentrations of M. avium were 9.1 � 0.0 log10 CFU/liter and 8.9 � 0.0 log10 CFU/liter, respectively). We propose that this standardized culture procedure could be used for detection of NTM in aquatic samples.

Surfactant-Based Fluorescent Quantum Carbon Dots: Synthesis and Application

2015 ◽  
Vol 1088 ◽  
pp. 381-385 ◽  
Author(s):  
Sandra Štěpánková ◽  
Ondřej Kozák ◽  
Radek Zbořil
Keyword(s):  
Fluorescence Quenching ◽  
Carbon Dots ◽  
Quantitative Method ◽  
Colloidal Stability ◽  
High Selectivity ◽  
Cetylpyridinium Chloride ◽  
Hydrothermal Carbonization ◽  
Fluorescent Carbon Dots

In this work I present fluorescent carbon dots (CDs) prepared by facile and inexpensive synthesis by hydrothermal carbonization from cationic surfactant cetylpyridinium chloride (CPC). These CDs show tunable photoluminescence as well as long-term colloidal stability. Moreover, CDs exhibit high selectivity and sensitivity towards Fe3+ions. Therefore a specific quantitative method is proposed for the determination of Fe3+ions based on fluorescence quenching of CDs.

Antimicrobial Activity of Cetylpyridinium Chloride Washes against Pathogenic Bacteria on Beef Surfaces†

2000 ◽  
Vol 63 (5) ◽  
pp. 593-600 ◽  
Author(s):  
CATHERINE N. CUTTER ◽  
WARREN J. DORSA ◽  
ANDRONICA HANDIE ◽  
SERGIO RODRIGUEZ-MORALES ◽  
XIANG ZHOU ◽  
...  
Keyword(s):  
Salmonella Typhimurium ◽  
Pathogenic Bacteria ◽  
Cetylpyridinium Chloride ◽  
Water Soluble ◽  
Human Consumption ◽  
Escherichia Coli O157 ◽  
E Coli ◽  
Lean Beef ◽  
Microbiological Analyses

Cetylpyridinium chloride (CPC), a water-soluble, neutral pH, colorless compound, is widely used in oral hygiene products to inhibit bacteria responsible for plaque. Previously, researchers have demonstrated that CPC not only reduces Salmonella Typhimurium on poultry but also prevents cross-contamination. To determine the effectiveness of CPC against pathogens associated with lean and adipose beef surfaces, several spray-washing experiments (862 kPa, 15 s, 35°C) with 1% (wt/vol) CPC were conducted. On lean beef surfaces, CPC immediately reduced 5 to 6 log10 CFU/cm2 of Escherichia coli O157:H7 and Salmonella Typhimurium to virtually undetectable levels (0 log10 CFU/cm2), as well as after 35 days of refrigerated (4°C), vacuum-packaged storage. On adipose beef surfaces, 5 log10 CFU/cm2 Salmonella Typhimurium and E. coli O157:H7 were reduced immediately (&gt;2.5 log10 CFU/cm2) with 1% CPC; by day 35 the reduction was &lt;1.3 log10 CFU/cm2. Further plate overlay analyses indicated that the effectiveness of CPC against pathogens on adipose surfaces was not hampered by the presence of meat components or fatty acids. Additional chemical and microbiological analyses of 1% CPC-treated beef surfaces subjected to a secondary water wash (following contact times of 0, 5, 10, 15, or 30 min) or grinding did reduce pathogenic bacteria and CPC levels. However, residual CPC levels following any of the treatments were considered excessive for human consumption. Despite the residual levels, this study is the first to demonstrate the effect of CPC on pathogenic bacteria associated with beef surfaces immediately after treatment and also after long-term, refrigerated, vacuum-packaged storage.

scholarly journals Topical therapy of combined inflammatory diseases of the pharynx and oral cavity

2019 ◽  
pp. 18-27
Author(s):  
S. V. Morozova ◽  
E. M. Pavlyshina
Keyword(s):  
Oral Cavity ◽  
Emotional Disorders ◽  
Inflammatory Diseases ◽  
Topical Therapy ◽  
Cetylpyridinium Chloride ◽  
Saliva Secretion ◽  
Pathogenetic Therapy ◽  
Dental Diseases ◽  
Inflammatory Changes

In the development of inflammatory diseases of the pharynx, etiological factors may include viral agents, bacterial infection, mainly streptococcal nature, fungal infection, diseases of the gastrointestinal tract (GERD, gastritis). Inflammatory changes in the oral mucosa and pharynx can be manifested by the main symptoms such as a feeling of dryness in the mouth and throat, difficulty or pain when swallowing. Xerostomy is a condition that develops when saliva secretion decreases or stops and is characterized by dryness in the oral cavity. With long-term course is accompanied by psycho-emotional disorders and contributes to the development of dental diseases (stomatitis, gingivitis). Septolete total including substances such as cetylpyridinium chloride and benzidamine, has antimicrobial and anti-inflammatory and can be used as an effective etiotropic and pathogenetic therapy of inflammatory diseases of the pharynx. It is also possible to use after otorhinolaryngological interventions(tonsilectomy).

Therapy and prevention for mental health: What if mental diseases are mostly not brain disorders?

2019 ◽  
Vol 42 ◽  
Author(s):  
John P. A. Ioannidis
Keyword(s):  
Mental Health ◽  
Mental Disease ◽  
Brain Disorders ◽  
Social Stressors ◽  
Labor Education ◽  
Mental Diseases ◽  
Long Term Follow Up ◽  
Political Decisions

AbstractNeurobiology-based interventions for mental diseases and searches for useful biomarkers of treatment response have largely failed. Clinical trials should assess interventions related to environmental and social stressors, with long-term follow-up; social rather than biological endpoints; personalized outcomes; and suitable cluster, adaptive, and n-of-1 designs. Labor, education, financial, and other social/political decisions should be evaluated for their impacts on mental disease.

Conceptual short-term memory (CSTM) supports core claims of Christiansen and Chater

2016 ◽  
Vol 39 ◽  
Author(s):  
Mary C. Potter
Keyword(s):  
Working Memory ◽  
Rapid Serial Visual Presentation ◽  
Language Comprehension ◽  
Short Term Memory ◽  
Visual Presentation ◽  
Long Term Memory ◽  
Short Term ◽  
Term Memory ◽  
Use Of Knowledge

AbstractRapid serial visual presentation (RSVP) of words or pictured scenes provides evidence for a large-capacity conceptual short-term memory (CSTM) that momentarily provides rich associated material from long-term memory, permitting rapid chunking (Potter 1993; 2009; 2012). In perception of scenes as well as language comprehension, we make use of knowledge that briefly exceeds the supposed limits of working memory.

Brief summary of Kleť photographic search programme for minor planets

1999 ◽  
Vol 173 ◽  
pp. 189-192
Author(s):  
J. Tichá ◽  
M. Tichý ◽  
Z. Moravec
Keyword(s):  
Ccd Camera ◽  
Minor Planet ◽  
Minor Planets ◽  
Main Belt

AbstractA long-term photographic search programme for minor planets was begun at the Kleť Observatory at the end of seventies using a 0.63-m Maksutov telescope, but with insufficient respect for long-arc follow-up astrometry. More than two thousand provisional designations were given to new Kleť discoveries. Since 1993 targeted follow-up astrometry of Kleť candidates has been performed with a 0.57-m reflector equipped with a CCD camera, and reliable orbits for many previous Kleť discoveries have been determined. The photographic programme results in more than 350 numbered minor planets credited to Kleť, one of the world's most prolific discovery sites. Nearly 50 per cent of them were numbered as a consequence of CCD follow-up observations since 1994.This brief summary describes the results of this Kleť photographic minor planet survey between 1977 and 1996. The majority of the Kleť photographic discoveries are main belt asteroids, but two Amor type asteroids and one Trojan have been found.

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