Antibacterial modification of an injectable, biodegradable, non-cytotoxic block copolymer-based physical gel with body temperature-stimulated sol-gel transition and controlled drug release

2016 ◽  
Vol 143 ◽  
pp. 342-351 ◽  
Author(s):  
Xiaowen Wang ◽  
Huawen Hu ◽  
Wenyi Wang ◽  
Ka I. Lee ◽  
Chang Gao ◽  
...  
RSC Advances ◽  
2020 ◽  
Vol 10 (41) ◽  
pp. 24507-24514
Author(s):  
Peihong Li ◽  
Xueyan Dai ◽  
Lijie Qu ◽  
Yanlong Sui ◽  
Chunling Zhang

Oligo(lysine)-F127 hydrogels have a temperature-responsive sol–gel transition and pH-responsive micelle morphology.


Polymers ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 698 ◽  
Author(s):  
Alina Amirova ◽  
Serafim Rodchenko ◽  
Mikhail Kurlykin ◽  
Andrey Tenkovtsev ◽  
Illia Krasnou ◽  
...  

Water-soluble, partially cross-linked poly-2-isopropyl-2-oxazoline combining the properties of chemical and physical gels was synthesized by a two-step procedure. Thermally induced sol-gel transition in its aqueous solution was studied by rheology, light scattering, and turbidimetry. It was demonstrated that the synthesized product is bimodal; it consists of linear and cross-linked components. The cross-linked components are responsible for the gelation, while the linear ones abate the viscosity growth. Heating the solution above the phase transition temperature leads to the self-assembly of the particles into a physical gel. The combination of chemical and physical cross-linking was found to be a prospective route for thermosensitive gel development.


2013 ◽  
Vol 683 ◽  
pp. 474-478
Author(s):  
Xi Liang Chen ◽  
Qing Nan Shi

As a kind of functional material, gelatin gel is widely used in controlled drug release, biological tissue engineering, photographic and food industries. Plenty of studies on the gelatin gel have been carried out by researchers, which include gelation mechanisms, gelation kinetics, analysis on the crosslinked structure and macroscopic performance during the gelation process. Numerical simulation is a new method used in the study of gelatin sol-gel transition process, which can make up for the deficiency of the experimental research. E.g., the dynamic gelation process makes it difficult to measure the structural and performance parameters in time and space scales in experiments. However, these problems have been solved by numerical simulation method in our previous work. The experimental, theoretical and numerical simulation research on sol-gel transition of gelatin is reviewed, and the progress and difficulties in this field are discussed.


2005 ◽  
Vol 44 (2) ◽  
pp. 888-899 ◽  
Author(s):  
Su Jeong Lee ◽  
Bo Ryeong Han ◽  
Sang Yeob Park ◽  
Dong Keun Han ◽  
Sung Chul Kim

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Jiufang Duan ◽  
Xiaojian Zhang ◽  
Jianxin Jiang ◽  
Chunrui Han ◽  
Jun Yang ◽  
...  

Cellulose possessingβ-cyclodextrin (β-CD) was used as a host molecule and cellulose possessing ferrocene (Fc) as a guest polymer. Infrared spectra, differential scanning calorimetry (DSC), ultraviolet spectroscopy (UV), and contact angle analysis were used to characterise the material structure and the inclusion behaviour. The results showed that theβ-CD-cellulose and the Fc-cellulose can form inclusion complexes. Moreover, ferrocene oxidation, and reduction of state can be adjusted by sodium hypochlorite (NaClO) as an oxidant and glutathione (GSH) as a reductant. In this study, a physical gel based onβ-CD-cellulose/Fc-cellulose was formed under mild conditions in which autonomous healing between cut surfaces occurred after 24 hours. The physical gel can be controlled in the sol-gel transition. The compressive strength of the Fc-cellulose/β-CD-cellulose gel increased with increased cellulose concentration. The host-guest interaction between the side chains of cellulose could strengthen the gel. The cellulose physical gel may eventually be used as a stimulus-responsive, healing material in biomedical applications.


2021 ◽  
Vol 42 (10) ◽  
pp. 2170040
Author(s):  
Haruna Mizuno ◽  
Kei Hashimoto ◽  
Keisuke Shigenobu ◽  
Hisashi Kokubo ◽  
Kazuhide Ueno ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document