Indomethacin electrospun nanofibers for colonic drug delivery: In vitro dissolution studies

Microsponges are the polymeric drug delivery systems composed of porous microspheres. They are tiny sponge like spherical particles that consists of myriad of inter-connecting voids within a non-collapsible structure with a large porous surface. The present work is to formulate and evaluate the Parecoxib Microsponge Hydrogel Sustained Release Tablet. The Microsponges of Parecoxib is prepared by Quasi-emulsion solvent diffusion method using Ethyl cellulose and Eudragit RS100 as polymers and Di-butyl phthalate as Plasticizer. And they are characterized for FTIR studies, production yield, particle size analysis, DSC and SEM. The production yield of formulations was from 77.77 to 82.75. FTIR and DSC studies are revealed that the drug and polymer are compatible with each other during preparation. The average diameter of Microsponge is ranged from 536.9 nm to 489.7. Parecoxib Microsponge hydrogel were prepared as sustained release tablets by using sustained release polymers like MCC, Magnesium stearate, Lactose and talc. Preformulation of Microsponge granules were carried out by various parameters and post formulation were carried out by In-vitro dissolution studies, hardness, friability and weight variation tests. Formulation F3 shows good results for the drug release kinetics as controlled release and F6 formulation shows good results for the in-vitro dissolution studies for sustained release. Key words: Microsponge hydrogel drug delivery, Parecoxib, Sustained drug release tablets, quasi emulsion solvent diffusion method.

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DESIGN AND DEVELOPMENT OF LOSARTAN POTASSIUM FLOATING DRUG DELIVERY SYSTEMS

International Journal of Applied Pharmaceutics ◽

10.22159/ijap.2018v10i6.28782 ◽

2018 ◽

Vol 10 (6) ◽

pp. 168

Author(s):

Prasanta Kumar Mohapatra ◽

Ch. Prathibha ◽

Vivek Tomer ◽

Mandeep Kumar Gupta ◽

Satyajit Sahoo

Keyword(s):

Drug Delivery ◽

Drug Release ◽

Angle Of Repose ◽

Losartan Potassium ◽

Fickian Diffusion ◽

In Vitro Dissolution ◽

Release Mechanism ◽

In Vitro Drug Release ◽

Dissolution Studies

Objective: The current study was projected to prepare a losartan potassium gastroretentive drug delivery system (GRDDS) of floating tablets was planned to enhance the gastric residence time, thus prolong the drug release.Methods: Effervescent floating matrix tablets of losartan potassium were prepared by direct compression technique using polymers like HPMC k4m, guar gum, and gum karaya, with lubricants magnesium stearate and talc. In the present study, sodium bicarbonate was incorporated as a gas generating agent. Total nine formulations were designed and evaluated for pre-compression parameters known as the angle of repose, bulk density, tapped density, Hausner’s ratio, compressibility index, and post-compression parameters are uniformity of weight, hardness, and drug content percentage, variability, in vitro buoyancy, dissolution studies, and Fourier transform infrared spectroscopy (FTIR).Results: An in vitro dissolution study was carried out by using buffer pH 1.2. From in vitro dissolution studies, it has been found that an increase in polymer concentration diminishes the drug release profile. The in vitro drug release percentage from F4-F9 formulations ranged from 60.28%-98.66% at the closing of 12 h and buoyancy found over 12 h.Conclusion: The in vitro drug release from F1-F3 and F7-F9 followed zero-order, F4 followed Higuchi order, F5 and F6 followed Hixon-Crowell release kinetics. The drug release mechanism was set up to be F1-F8 non-Fickian (anomalous behavior) and F9 having Fickian diffusion type.

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Dissolution improvement of solid self-emulsifying drug delivery systems of fenofi brate using an inorganic high surface adsorption material

Acta Pharmaceutica ◽

10.1515/acph-2015-0003 ◽

2015 ◽

Vol 65 (1) ◽

pp. 29-42 ◽

Cited By ~ 12

Author(s):

Gamal Shazly ◽

Kazi Mohsin

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Water Solubility ◽

High Surface ◽

Amorphous State ◽

Delivery Systems ◽

Classification Systems ◽

In Vitro Dissolution ◽

Dissolution Studies

Abstract Solidification of lipid formulations using adsorbents is a recent technique attracting great interest due to its favourable properties including flexibility in dose division, reduction of intra-subject and inter-subject variability, improvement in efficacy/safety profile and enhancement of physical/ chemical stability. The current study aims to convert liquid self-emulsifying/nanoemulsifying drug delivery systems (SEDDS/SNEDDS) into solid SEDDS/SNEDDS and to assess how adsorption of the drug onto an inorganic high surface area material, NeusilinR grade US2 (NUS2), affects its in vitro dissolution performance. Lipid formulation classification systems (LFCS) Type III formulations were designed for the model anti-cholesterol drug fenofibrate. NUS2 was used to solidify the SEDDS/SNEDDS. Particle size and SEM analyses of solid SEDDS/SNEDDS powder were carried out to investigate the adsorption efficiency. In vitro dissolution studies were conducted to compare the developed formulations with the marketed product. The results of characterization studies showed that the use of 50 % (m/m) adsorbent resulted in superior flowability and kept the drug stable is amorphous state. Dissolution studies allow the conclusion that the formulation containing a surfactant of higher water solubility (particularly, Type IIIB SNEDDS) has comparably faster and higher release profiles than Type IIIA (SEDDS) and marketed product

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3D printing of PVA capsular devices for modified drug delivery: design and in vitro dissolution studies

Drug Development and Industrial Pharmacy ◽

10.1080/03639045.2020.1791166 ◽

2020 ◽

Vol 46 (9) ◽

pp. 1416-1426

Author(s):

Ivana Cotabarren ◽

Loreana Gallo

Keyword(s):

Drug Delivery ◽

3D Printing ◽

In Vitro Dissolution ◽

Dissolution Studies

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Selective LC determination of cabergoline in the bulk drug and in tablets: In vitro dissolution studies

Chromatographia ◽

10.1016/s0009-5893(07)82061-3 ◽

2007 ◽

Vol 65 (9-10) ◽

pp. 561-567

Author(s):

A ONAL ◽

O SAGIRLI ◽

D SENSOY

Keyword(s):

In Vitro Dissolution ◽

Dissolution Studies ◽

Bulk Drug

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Formulation and Evaluation of Bilayer Sustained Release Tablets of Salbutamol and Theophylline

International Journal of Pharmaceutical Sciences and Nanotechnology ◽

10.37285/ijpsn.2009.2.3.7 ◽

2009 ◽

Vol 2 (3) ◽

pp. 638-646

Author(s):

R. Nagaraju ◽

Rajesh Kaza

Keyword(s):

Ethyl Cellulose ◽

Xanthan Gum ◽

Dosage Forms ◽

In Vitro Dissolution ◽

Dissolution Studies ◽

Sustained Release Tablets ◽

Dissolution Apparatus ◽

Single Dosage

Salbutamol and theophylline are available in conventional dosage forms, administered four times a day, leading to saw tooth kinetics and resulting in ineffective therapy. The combination of these two drugs in a single dosage form will enhance the patient compliance and prolong bronchodilation. Various polymers, such as hydroxy propyl methylcellulose K4M (HPMC- K4M), hydroxy propyl methylcellulose K100M (HPMC- K100M), xanthan gum, ethyl cellulose and hydroxy propyl methylcellulose phthalate (HPMC-P) were studied. HPMC-P and HPMC- K4M were found to be best in controlling the release. In-vitro dissolution studies were carried out for all the bi-layered tablets developed using USP dissolution apparatus type 2 (paddle). It was found that the tablet FB15-FW3 showed 50% release of salbutamol in first hour and the remaining was released for eight hours. However, theophylline was found to be released as per the USP specifications. The IR spectrum was taken for FB15-FW3 formulation and it revealed that there is no disturbance in the principal peaks of pure drugs salbutamol and theophylline. This further confirms the integrity of pure drugs and no incompatibility of them with excipients. Also, formulation of FB15-FW3 has shown required release pattern and complies with all the evaluated parameters and comparable to the marketed formulation.

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Formulation of Oral Mucoadhesive Tablets using Mucilage Isolated from Buchanania lanzan spreng Seeds

International Journal of Pharmaceutical Sciences and Nanotechnology ◽

10.37285/ijpsn.2014.7.2.11 ◽

2014 ◽

Vol 7 (2) ◽

pp. 2494-2503

Author(s):

Sudarshan Singh ◽

Ayaz Ahmad ◽

Sunil Bothara B

Keyword(s):

Drug Delivery ◽

Guar Gum ◽

Physical Property ◽

Flow Property ◽

Relative Effect ◽

Losartan Potassium ◽

In Vitro Dissolution ◽

Wet Granulation ◽

Microbial Count

The present study was taken to formulate and evaluate mucilage obtained from Buchanania lanzan spreng seeds (BL) belonging to family anacardiacea for oral mucoadhesive drug delivery system containing losartan potassium. Physiochemical characteristics of mucilage, such as swelling index, microbial count, viscosity, hydration capacity, flow property, and pH were studied. The mucilage was evaluated for its mucoadhesive properties in compressed tablet, containing losartan potassium. Granules were prepared by wet granulation process using polyvinylpyrrolidone as binding agent. Mucilage was used in four different concentrations i.e., 21, 42 and 55% w/w. The tablet were prepared and evaluated for its physical property. Further, in vitro dissolution and swelling index was determined. The property of bioadhesive strength of isolated mucilage was compared with Guar gum and HPMC E5LV, which was used as standard mucoadhesive agent concentration. Bioadhesive strength of the tablet was measured on the modified physical balance. Result revealed that tablets had good physiochemical properties, and drug release was retarded as concentration of mucilage was increased. The force of adhesion was obtained 0.1238N, 0.2822N, 0.5175N, 0.8679N and 0.3983N respectively for F1, F2, F3, F4 and F5. Formulations were subjected for study the effect of agitation at different rpm. Formulation showed relative effect on release of drug from formulation. All the formulations were subjected to stability studies for three months, all formulations showed stability with respect to release pattern. In conclusions, these results indicate that the seed mucilage of BL can be a suitable excipient for oral mucoadhesive drug delivery systems.

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An In Vivo Predictive Dissolution Methodology (iPD Methodology) with a BCS Class IIb Drug Can Predict the In Vivo Bioequivalence Results: Etoricoxib Products

Pharmaceutics ◽

10.3390/pharmaceutics13040507 ◽

2021 ◽

Vol 13 (4) ◽

pp. 507

Author(s):

Isabel Gonzalez-Alvarez ◽

Marival Bermejo ◽

Yasuhiro Tsume ◽

Alejandro Ruiz-Picazo ◽

Marta Gonzalez-Alvarez ◽

...

Keyword(s):

Plasma Concentrations ◽

In Vitro Dissolution ◽

Case Examples ◽

Dissolution Studies ◽

Weak Bases ◽

Transit Times ◽

Class Iib ◽

The Impact

The purpose of this study was to predict in vivo performance of three oral products of Etoricoxib (Arcoxia® as reference and two generic formulations in development) by conducting in vivo predictive dissolution with GIS (Gastro Intestinal Simulator) and computational analysis. Those predictions were compared with the results from previous bioequivalence (BE) human studies. Product dissolution studies were performed using a computer-controlled multicompartmental dissolution device (GIS) equipped with three dissolution chambers, representing stomach, duodenum, and jejunum, with integrated transit times and secretion rates. The measured dissolved amounts were modelled in each compartment with a set of differential equations representing transit, dissolution, and precipitation processes. The observed drug concentration by in vitro dissolution studies were directly convoluted with permeability and disposition parameters from literature to generate the predicted plasma concentrations. The GIS was able to detect the dissolution differences among reference and generic formulations in the gastric chamber where the drug solubility is high (pH 2) while the USP 2 standard dissolution test at pH 2 did not show any difference. Therefore, the current study confirms the importance of multicompartmental dissolution testing for weak bases as observed for other case examples but also the impact of excipients on duodenal and jejunal in vivo behavior.

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