This paper analyses the stress state of sintered hollow block infilled insulation masonry under practical conditions. Based on the fact that the static loading performance of the new masonry block can be used in masonry structure, the comparative experiment research focused on the seismic performance between masonry works made of the new block and traditional sintered perforated brick with horizontal and vertical load working simultaneously, damage regulars and corrective measures are key points. Results show the mechanical performance of the new block masonry is worse than sintered perforated brick masonry in fragility and vertical loading capability. To get the same mechanical performance, the new block masonry should be improved in rib width, rib number and distance, especially in restraint by construction columns and ring beams.