Effect of tolbutamide on myocardial metabolism and mechanical performance of the diabetic rat

Diabetes ◽  
1984 ◽  
Vol 33 (12) ◽  
pp. 1138-1143 ◽  
Author(s):  
B. H. Tan ◽  
G. L. Wilson ◽  
S. W. Schaffer
Keyword(s):  
Myocardial Metabolism ◽  
Mechanical Performance ◽  
Diabetic Rat

Effect of Tolbutamide on Myocardial Metabolism and Mechanical Performance of the Diabetic Rat

Diabetes ◽  
1984 ◽  
Vol 33 (12) ◽  
pp. 1138-1143 ◽  
Author(s):  
B. H. Tan ◽  
G. L. Wilson ◽  
S. W. Schaffer
Keyword(s):  
Myocardial Metabolism ◽  
Mechanical Performance ◽  
Diabetic Rat

Myocardial metabolism and performance in hypoxia: effect of epinephrine

1978 ◽  
Vol 45 (5) ◽  
pp. 791-796 ◽  
Author(s):  
J. Kypson ◽  
G. Hait
Keyword(s):  
Fatty Acids ◽  
Heart Rate ◽  
Free Fatty Acids ◽  
Glucose Utilization ◽  
Myocardial Metabolism ◽  
Mechanical Performance ◽  
Adenine Nucleotides ◽  
Metabolic Changes ◽  
And Performance ◽  
Energetic Reserves

Effects of epinephrine (10(-5) M) on mechanical performance, glycolysis, glycogenolysis, lipolysis, and metabolism of adenine nucleotides were studied in isolated hypoxic rabbit hearts. The exposure of hearts to hypoxia decreased their mechanical performance and heart rate, but increased their utilization of glucose by 50% and the release of lactate by 139%. Myocardial stores of glycogen and ATP declined by 53 and 84%, respectively, but their breakdown products such as lactate, pyruvate, AMP, and inosine accumulated in these hearts. Myocardial content of free fatty acids decreased, and the amount of glycerol increased in hypoxic hearts. Epinephrine stimulated mechanical performance and heart rate of hypoxic hearts, but decreased myocardial glycogen and ATP even more by 62 and 33%, respectively. Though glucose utilization remained unchanged, the release of lactate increased by 66% from hypoxic hearts treated with epinephrine. However, epinephrine failed to stimulate myocardial lipolysis in hypoxic hearts. These metabolic changes due to epinephrine would lead to accelerated depletion of energetic reserves in hypoxic heart and its earlier deterioration.

Performance of diabetic rat hearts: effects of anoxia and increased work

1980 ◽  
Vol 239 (5) ◽  
pp. H614-H620 ◽  
Author(s):  
C. G. Ingebretsen ◽  
P. Moreau ◽  
C. Hawelu-Johnson ◽  
W. R. Ingebretsen
Keyword(s):  
Cardiac Output ◽  
Coronary Flow ◽  
Mechanical Performance ◽  
Left Ventricular Pressure ◽  
Left Ventricular ◽  
Ventricular Pressure ◽  
Diabetic Rat ◽  
Ventricular Performance ◽  
Pressure Development ◽  
Heart Preparation

An isolated perfused working rat heart preparation was used to assess the effect of alloxan-induced diabetes on myocardial performance. Ventricular performance was assessed under different aortic afterload, isoproterenol-stimulated and anoxic conditions. Basal left ventricular pressure development and rate of rise of ventricular pressure were depressed in hearts from diabetic animals. Neither coronary flow nor cardiac output were affected by diabetes. The dose and temporal responses to an infusion of isoproterenol were unaltered in diabetic hearts. Isoproterenol increased coronary flow by 50% and elevated ventricular pressure, dP/dt, and cardiac output by two- to threefold. Anoxia depressed ventricular pressure to below 20% of control within 5 min in both diabetic and normal hearts. Reoxygenation after 10 min of anoxia produced equivalent recovery in both groups working against a 52-mmHg aortic afterload, whereas recovery after 20 or 30 min of anoxia, was depressed in diabetic hearts. Elevating aortic afterload decreased performance of diabetic hearts and decreased their ability to recover from a 10-min anoxic exposure. Many of these observed differences in mechanical performance of diabetic hearts can be overcome by high glucose or insulin in the perfusion media.

Troglitazone prevents falty changes of the liver in obese diabetic rat

2001 ◽  
Vol 120 (5) ◽  
pp. A207-A208
Author(s):  
D JIA ◽  
T AKIYAMA ◽  
K FUKUMITSU ◽  
M YAMAMOTO ◽  
S ABE ◽  
...  
Keyword(s):  
Diabetic Rat

Effects of empagliflozin on oxidative stress and endothelial dysfunction in STZ-induced Type 1 diabetic rat

2014 ◽  
Vol 9 (S 01) ◽  
Author(s):  
M Oelze ◽  
S Kröller-Schön ◽  
M Mader ◽  
E Zinßius ◽  
P Stamm ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Endothelial Dysfunction ◽  
Diabetic Rat

The Mechanical Performance of Carbon Fibres- Addressing the Role of Microstructure

2019 ◽  
Author(s):  
Peter Peter ◽  
Claudia Creighton ◽  
David Fox ◽  
Pablo Mota Santiago ◽  
Adrian Hawley ◽  
...  
Keyword(s):  
Mechanical Performance ◽  
Carbon Fibres

Microstructural and Mechanical Behaviour Evaluation of Mg-Al-Zn Alloy Friction Stir Welded Joint

2020 ◽  
Vol 17 (3) ◽  
pp. 8150-8159
Author(s):  
Kulwant Singh ◽  
Gurbhinder Singh ◽  
Harmeet Singh
Keyword(s):  
Heat Treatment ◽  
Friction Stir Welding ◽  
Magnesium Alloys ◽  
Mechanical Performance ◽  
Fuel Efficiency ◽  
Research Work ◽  
Grain Structure ◽  
Tensile Fracture ◽  
Friction Stir ◽  
The Impact

The weight reduction concept is most effective to reduce the emissions of greenhouse gases from vehicles, which also improves fuel efficiency. Amongst lightweight materials, magnesium alloys are attractive to the automotive sector as a structural material. Welding feasibility of magnesium alloys acts as an influential role in its usage for lightweight prospects. Friction stir welding (FSW) is an appropriate technique as compared to other welding techniques to join magnesium alloys. Field of friction stir welding is emerging in the current scenario. The friction stir welding technique has been selected to weld AZ91 magnesium alloys in the current research work. The microstructure and mechanical characteristics of the produced FSW butt joints have been investigated. Further, the influence of post welding heat treatment (at 260 °C for 1 h) on these properties has also been examined. Post welding heat treatment (PWHT) resulted in the improvement of the grain structure of weld zones which affected the mechanical performance of the joints. After heat treatment, the tensile strength and elongation of the joint increased by 12.6 % and 31.9 % respectively. It is proven that after PWHT, the microhardness of the stir zone reduced and a comparatively smoothened microhardness profile of the FSW joint obtained. No considerable variation in the location of the tensile fracture was witnessed after PWHT. The results show that the impact toughness of the weld joints further decreases after post welding heat treatment.

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