Age-related hearing loss influences functional connectivity of auditory cortex for the McGurk illusion

Cortex ◽  
2020 ◽  
Vol 129 ◽  
pp. 266-280
Author(s):  
Stephanie Rosemann ◽  
Dakota Smith ◽  
Marie Dewenter ◽  
Christiane M. Thiel
Keyword(s):  
Hearing Loss ◽  
Functional Connectivity ◽  
Auditory Cortex ◽  
Age Related ◽  
Mcgurk Illusion ◽  
Age Related Hearing Loss

scholarly journals Reduced resting state functional connectivity with increasing age-related hearing loss and McGurk susceptibility

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Alina Schulte ◽  
Christiane M. Thiel ◽  
Anja Gieseler ◽  
Maike Tahden ◽  
Hans Colonius ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Functional Connectivity ◽  
Resting State ◽  
Mcgurk Effect ◽  
Functional Coupling ◽  
Resting State Functional Connectivity ◽  
Visual Integration ◽  
Age Related ◽  
Hearing Thresholds ◽  
Age Related Hearing Loss

Abstract Age-related hearing loss has been related to a compensatory increase in audio-visual integration and neural reorganization including alterations in functional resting state connectivity. How these two changes are linked in elderly listeners is unclear. The current study explored modulatory effects of hearing thresholds and audio-visual integration on resting state functional connectivity. We analysed a large set of resting state data of 65 elderly participants with a widely varying degree of untreated hearing loss. Audio-visual integration, as gauged with the McGurk effect, increased with progressing hearing thresholds. On the neural level, McGurk illusions were negatively related to functional coupling between motor and auditory regions. Similarly, connectivity of the dorsal attention network to sensorimotor and primary motor cortices was reduced with increasing hearing loss. The same effect was obtained for connectivity between the salience network and visual cortex. Our findings suggest that with progressing untreated age-related hearing loss, functional coupling at rest declines, affecting connectivity of brain networks and areas associated with attentional, visual, sensorimotor and motor processes. Especially connectivity reductions between auditory and motor areas were related to stronger audio-visual integration found with increasing hearing loss.

scholarly journals Functional Connectivity of Heschl’s Gyrus Associated With Age-Related Hearing Loss: A Resting-State fMRI Study

2019 ◽  
Vol 10 ◽  
Author(s):  
Megan C. Fitzhugh ◽  
Angela Hemesath ◽  
Sydney Y. Schaefer ◽  
Leslie C. Baxter ◽  
Corianne Rogalsky
Keyword(s):  
Hearing Loss ◽  
Functional Connectivity ◽  
Resting State ◽  
Resting State Fmri ◽  
Heschl’S Gyrus ◽  
Age Related ◽  
Fmri Study ◽  
Heschl's Gyrus ◽  
Age Related Hearing Loss

Regulating Age-Related Hearing Loss with Bisphenol A via the Long Non-Coding RNA X Inactive Specific Transcript and MicroRNA-34a-5p Pathways

2020 ◽  
Vol 12 (8) ◽  
pp. 987-995
Author(s):  
Shifei Wang ◽  
Cheng Rao ◽  
Xingyu Huang ◽  
Tianhong Xie ◽  
Linling Su ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Bisphenol A ◽  
Auditory Cortex ◽  
Neuronal Cell ◽  
Specific Transcript ◽  
Age Related ◽  
Non Coding Rna ◽  
Lncrna Xist ◽  
Age Related Hearing Loss ◽  
Long Non Coding Rna

Age-related hearing loss (AHL) is a common, high-incidence, perceptual disease in the elderly population worldwide. Since bisphenol A (BPA) has been reported to associate with cell apoptosis, we hypothesize that BPA can inhibit the neuronal apoptosis in AHL. Forty Wistar rats were recruited to model AHL; they were then treated with different doses of BPA. We used auditory brainstem response testing to measure the BPA-induced improvement in the rats’ hearing. We examined the proliferation and apoptosis of the auditory cortical neurons in the rats with MTT assay and flow cytometry. Also, to delineate the underlying mechanism of BPA’s effect on AHL, we quantitated the expression level of long non-coding RNA X inactive specific transcript (lncRNA XIST) and miR-34a-5p in the rats’ auditory cortex with a novel method called nanoparticle PCR. We found that BPA intervention improved the hearing of AHL model rats, enhanced neuronal cell proliferation, restricted neuronal cell apoptosis, upregulated miR-34a-5p levels, and downregulated lncRNA XIST levels. The dual-luciferase reporter (DLR) assay revealed that BPA inhibited the apoptosis of auditory cortex neurons by targeting miR-34a-5p with lncRNA XIST and regulated the process of AHL. Therefore, we come to a conclusion that BPA contributes to the improvement of AHL, which may be achieved by upregulating miR-34a-5p and inhibiting the apoptosis of auditory cortex neurons via lncRNA XIST.

The miR-34a/Bcl-2 Pathway Contributes to Auditory Cortex Neuron Apoptosis in Age-Related Hearing Loss

2017 ◽  
Vol 22 (2) ◽  
pp. 96-103 ◽  
Author(s):  
Qiuhong Huang ◽  
Yongkang Ou ◽  
Hao Xiong ◽  
Haidi Yang ◽  
Zhigang Zhang ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Auditory Cortex ◽  
Molecular Mechanisms ◽  
Primary Auditory Cortex ◽  
Auditory Brainstem ◽  
Hearing Ability ◽  
Age Related ◽  
Brainstem Response ◽  
The Central Nervous System ◽  
Age Related Hearing Loss

Hypothesis: The miR-34a/Bcl-2 signaling pathway may play a role in the mechanisms related to age-related hearing loss (AHL) in the auditory cortex. Background: The auditory cortex plays a key role in the recognition and processing of complex sound. It is difficult to explain why patients with AHL have poor speech recognition, so increasing numbers of studies have focused on its central change. Although micro (mi)RNAs in the central nervous system have recently been increasingly reported to be associated with age-related diseases, the molecular mechanisms of AHL in the auditory cortex are not fully understood. Methods: The auditory brainstem response was used to assess the hearing ability of C57BL/6 mice, and q-PCR, immunohistochemistry, and Western blotting were used to detect the expression levels of miR-34a and Bcl-2 in the mouse auditory cortex. TUNEL and DNA fragmentation were adopted to detect the apoptosis of neurons in the auditory cortex. To verify the relationship of miR-34a and Bcl-2, we transfected an miR-34a mimic or miR-34a inhibitor into primary auditory cortex neurons. Results: In this study, miR-34a/Bcl-2 signaling was examined in auditory cortex neurons during aging. miR-34a and apoptosis increased in the auditory cortex neurons of C57BL/6 mice with aging, whereas an age-related decrease in Bcl-2 was determined. In the primary neurons of the auditory cortex, miR-34a overexpression inhibited Bcl-2, leading to an increase in apoptosis. Moreover, miR-34a knockdown increased Bcl-2 expression and diminished apoptosis. Conclusion: Our results support a link between age-related apoptosis in auditory cortex neurons and miR-34a/Bcl-2 signaling, which may serve as a potential mechanism of the expression of AHL in the auditory cortex.

SIRT1 expression in the cochlea and auditory cortex of a mouse model of age-related hearing loss

2014 ◽  
Vol 51 ◽  
pp. 8-14 ◽  
Author(s):  
Hao Xiong ◽  
Min Dai ◽  
Yongkang Ou ◽  
Jiaqi Pang ◽  
Haidi Yang ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Mouse Model ◽  
Auditory Cortex ◽  
Sirt1 Expression ◽  
Age Related ◽  
Age Related Hearing Loss

Expression of G9a in Auditory Cortex Is Downregulated in a Rat Model of Age-Related Hearing Loss

2020 ◽  
Author(s):  
Qian Li ◽  
Yang-hong Xiang ◽  
Xiao-jun Liang ◽  
Yun Zhang ◽  
Peng-peng Zhao ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Auditory Cortex ◽  
Rat Model ◽  
Age Related ◽  
Age Related Hearing Loss

scholarly journals Treatment of Age-Related Hearing Loss Alters Audiovisual Integration and Resting-State Functional Connectivity: A Randomized Controlled Pilot Trial

eNeuro ◽  
2021 ◽  
pp. ENEURO.0258-21.2021
Author(s):  
Stephanie Rosemann ◽  
Anja Gieseler ◽  
Maike Tahden ◽  
Hans Colonius ◽  
Christiane M. Thiel
Keyword(s):  
Hearing Loss ◽  
Functional Connectivity ◽  
Resting State ◽  
Pilot Trial ◽  
Audiovisual Integration ◽  
Resting State Functional Connectivity ◽  
Randomized Controlled ◽  
Age Related ◽  
Age Related Hearing Loss

scholarly journals Aging But Not Age-Related Hearing Loss Dominates the Decrease of Parvalbumin Immunoreactivity in the Primary Auditory Cortex of Mice

eNeuro ◽  
2020 ◽  
Vol 7 (3) ◽  
pp. ENEURO.0511-19.2020
Author(s):  
Meike M. Rogalla ◽  
K. Jannis Hildebrandt
Keyword(s):  
Hearing Loss ◽  
Auditory Cortex ◽  
Primary Auditory Cortex ◽  
Age Related ◽  
Age Related Hearing Loss
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